公开(公告)号：US20210331998A1

公开(公告)日：2021-10-28

申请号：US17369735

申请日：2021-07-07

申请人： RETROTOPE, INC.

发明人： Dragoslav Vidovic ,  Mikhail Sergeevich Shchepinov

IPC分类号： C07C67/30 ,  C07C5/00 ,  C07C407/00 ,  C07C29/00 ,  C07B59/00 ,  C07C51/347 ,  C07C11/12

摘要： Methods for preparing isotopically modified 1,4-diene systems from non-isotopically modified 1,4-dienes involve selective oxidation of one or more bis-allylic position(s), or the preparation of isotopically modified 1,4-diene systems via trapping pi-allylic complexes with a source of deuterium or tritium. Such methods are useful for preparing isotopically modified polyunsaturated lipid including polyunsaturated fatty acids and polyunsaturated fatty acid derivatives.

公开(公告)号：US20190282529A1

公开(公告)日：2019-09-19

申请号：US16348087

申请日：2017-11-16

申请人： RETROTOPE, INC.

发明人： Mikhail Sergeevich Shchepinov

IPC分类号： A61K31/202 ,  A61P25/28 ,  A61B5/055 ,  A61B5/00

摘要： Methods are provided of identifying a subject having impaired aldehyde dehydrogenase activity; and administering to the subject a compound comprising an isotopicaliy-modified polyunsaturated fatty acid, an isotopicaliy-modified polyunsaturated fatty acid ester, an isotopicaliy-modified polyunsaturated fatty acid thioester, an isotopicaliy-modified polyunsaturated fatty acid amide, a polyunsaturated fatty acid mimetic, or an isotopicaliy-modified polyunsaturated fatty acid pro-drug, the compound having an isotopic modification that reduces oxidation of the compound, thereby reducing production in the subject of substrate for aldehyde dehydrogenase. Some aspects provide coadministering an isotopicaliy-modified polyunsaturated fatty acid and an oxylipin.

公开(公告)号：US20170172195A1

公开(公告)日：2017-06-22

申请号：US15446922

申请日：2017-03-01

申请人： Retrotope, Inc.

发明人： Mikhail Sergeevich Shchepinov

IPC分类号： A23L33/12 ,  C07C255/30 ,  A23L33/10 ,  C07C279/14 ,  C07C57/03 ,  A23D9/00 ,  C07H19/16 ,  C07C229/26

CPC分类号： A23L33/12 ,  A23D9/00 ,  A23D9/007 ,  A23K10/12 ,  A23K50/80 ,  A23L33/10 ,  A23L33/105 ,  A23L33/13 ,  A23L33/135 ,  A23L33/175 ,  A23L33/18 ,  A23L33/20 ,  A23V2002/00 ,  A61K9/0019 ,  A61K31/201 ,  C07B2200/05 ,  C07C57/03 ,  C07C229/26 ,  C07C255/30 ,  C07C279/14 ,  C07H19/16 ,  A23V2200/302 ,  A23V2200/30 ,  A23V2250/1872 ,  A23V2250/063 ,  A23V2250/0606 ,  A23V2250/206

摘要： A nutrient composition comprises an essential nutrient in which at least one exchangeable H atom is 2H and/or at least one C atom is 13C. The nutrient is thus protected from, inter alia, active oxygen species.

公开(公告)号：US20240091189A1

公开(公告)日：2024-03-21

申请号：US18275968

申请日：2022-02-04

申请人： Retrotope, Inc.

发明人： Peter Milner ,  Mikhail Sergeevich Shchepinov

IPC分类号： A61K31/202 ,  A61K31/232 ,  A61P25/28

CPC分类号： A61K31/202 ,  A61K31/232 ,  A61P25/28

摘要： Disclosed are diagnostic methods for assessing the presence or absence of a therapeutic concentration of a deuterated polyunsaturated fatty acid in diseased neurons during treatment of a patient with a neurodegenerative disease.

公开(公告)号：US11447441B2

公开(公告)日：2022-09-20

申请号：US17412797

申请日：2021-08-26

申请人： Retrotope, Inc.

发明人： Dragoslav Vidovic ,  Mikhail Sergeevich Shchepinov

IPC分类号： C07C67/30 ,  C07C5/00 ,  C07C407/00 ,  C07C29/00 ,  C07B59/00 ,  C07C69/587 ,  C07C51/347 ,  C07C11/12 ,  A61P1/16

摘要： Methods for preparing isotopically modified 1,4-diene systems from non-isotopically modified 1,4-dienes involve selective oxidation of one or more bis-allylic position(s), or the preparation of isotopically modified 1,4-diene systems via trapping pi-allylic complexes with a source of deuterium or tritium. Such methods are useful for preparing isotopically modified polyunsaturated lipid including polyunsaturated fatty acids and polyunsaturated fatty acid derivatives.

公开(公告)号：US20220249423A1

公开(公告)日：2022-08-11

申请号：US17408285

申请日：2021-08-20

申请人： RETROTOPE, INC.

发明人： Peter MILNER ,  Mikhail Sergeevich Shchepinov

IPC分类号： A61K31/202 ,  G16H20/10 ,  G16H20/60

摘要： Disclosed are methods for inhibiting the progression of neurodegenerative disease. The methods include administering to a patient suffering from such a disease a composition comprising either deuterated arachidonic acid or an ester thereof.

公开(公告)号：US20220249422A1

公开(公告)日：2022-08-11

申请号：US17391909

申请日：2021-08-02

申请人： RETROTOPE, INC.

发明人： Peter MILNER ,  Mikhail Sergeevich Shchepinov

IPC分类号： A61K31/202 ,  A61K31/232 ,  A61P25/28

摘要： Disclosed are methods for inhibiting the progression of neurodegenerative disease. The methods include administering to a patient suffering from such a disease a composition comprising either deuterated linoleic acid or an ester thereof.

公开(公告)号：US20220133668A1

公开(公告)日：2022-05-05

申请号：US17512531

申请日：2021-10-27

申请人： RETROTOPE, INC.

发明人： Mikhail Sergeevich Shchepinov

IPC分类号： A61K31/202 ,  A61P25/28 ,  A61B5/055 ,  A61B5/00 ,  G01N33/573 ,  G01N33/68 ,  C12Q1/32 ,  A61P25/00 ,  A61K31/375 ,  A61K31/557 ,  A61K31/66 ,  A61K31/122 ,  A61K31/355

摘要： Methods are provided of identifying a subject having impaired aldehyde dehydrogenase activity; and administering to the subject a compound comprising an isotopicaliy-modified polyunsaturated fatty acid, an isotopicaliy-modified polyunsaturated fatty acid ester, an isotopicaliy-modified polyunsaturated fatty acid thioester, an isotopicaliy-modified polyunsaturated fatty acid amide, a polyunsaturated fatty acid mimetic, or an isotopicaliy-modified polyunsaturated fatty acid pro-drug, the compound having an isotopic modification that reduces oxidation of the compound, thereby reducing production in the subject of substrate for aldehyde dehydrogenase. Some aspects provide coadministering an isotopicaliy-modified polyunsaturated fatty acid and an oxylipin.

公开(公告)号：US20190084913A1

公开(公告)日：2019-03-21

申请号：US16192387

申请日：2018-11-15

申请人： Retrotope, Inc.

发明人： Dragoslav Vidovic ,  Mikhail Sergeevich Shchepinov

IPC分类号： C07C67/30 ,  C07C11/12 ,  C07C5/00 ,  C07C29/00 ,  C07C407/00 ,  C07C51/347

摘要： Methods for preparing isotopically modified 1,4-diene systems from non-isotopically modified 1,4-dienes involve selective oxidation of one or more bis-allylic position(s), or the preparation of isotopically modified 1,4-diene systems via trapping pi-allylic complexes with a source of deuterium or tritium. Such methods are useful for preparing isotopically modified polyunsaturated lipid including polyunsaturated fatty acids and polyunsaturated fatty acid derivatives.

公开(公告)号：US09320289B2

公开(公告)日：2016-04-26

申请号：US14551450

申请日：2014-11-24

申请人： RETROTOPE, INC.

发明人： Mikhail Sergeevich Shchepinov

IPC分类号： A23D9/00 ,  A23D9/007 ,  A23K1/00 ,  A23K1/18 ,  A23L1/30 ,  A23L1/305 ,  A23L1/307

CPC分类号： A23L33/12 ,  A23D9/00 ,  A23D9/007 ,  A23K10/12 ,  A23K50/80 ,  A23L33/10 ,  A23L33/105 ,  A23L33/13 ,  A23L33/135 ,  A23L33/175 ,  A23L33/18 ,  A23L33/20 ,  A23V2002/00 ,  A61K9/0019 ,  A61K31/201 ,  C07B2200/05 ,  C07C57/03 ,  C07C229/26 ,  C07C255/30 ,  C07C279/14 ,  C07H19/16 ,  A23V2200/302 ,  A23V2200/30 ,  A23V2250/1872 ,  A23V2250/063 ,  A23V2250/0606 ,  A23V2250/206

摘要： A nutrient composition comprises an essential nutrient in which at least one exchangeable H atom is 2H and/or at least one C atom is 13C. The nutrient is thus protected from, inter alia, active oxygen species.

摘要翻译： 营养成分包含其中至少一个可交换H原子为2H和/或至少一个C原子为13 C的必需营养物质。 因此，营养物尤其可以被保护而不是活性氧。