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公开(公告)号：US20100323419A1
公开(公告)日：2010-12-23
申请号：US12668369
申请日：2008-07-09
摘要： Systems and methods for manipulating molecular material are provided. In one aspect, for example, a method for manipulating molecular material may include positioning an uncharged needle structure in electrical proximity with a charged molecular material at a first locus in a liquid environment, charging the needle structure such that at least a portion of the charged molecular material becomes associated with the needle structure, moving the needle structure and the first locus relative to one another, and discharging the needle structure to disassociate the charged molecular material at a second locus.
摘要翻译： 提供了操作分子材料的系统和方法。 在一个方面，例如，用于操纵分子材料的方法可以包括在液体环境中的第一位置处将不带电的针结构定位成与电荷分子材料电接近，对针结构进行充电，使得至少一部分带电 分子材料与针结构相关联，使针结构和第一轨迹相对移动，并且排出针结构以在第二位置分离带电分子材料。
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公开(公告)号：US20100248343A1
公开(公告)日：2010-09-30
申请号：US12816183
申请日：2010-06-15
IPC分类号： C12M1/00
摘要： Devices and methods for constraining or holding a cell are provided. In one aspect, for example, a cellular constraint device is provided. Such a device can include a support surface and at least one constraining arm movably coupled to the support surface. The constraining arm has a first position in which the constraining arm is substantially parallel and substantially adjacent to the support surface. Additionally, at least a portion of the constraining arm is movable away from the support surface to a second position where the constraining arm is operable to constrain a single cell.
摘要翻译： 提供了用于约束或保持单元的装置和方法。 在一个方面，例如，提供了一种蜂窝约束装置。 这种装置可以包括支撑表面和可移动地联接到支撑表面的至少一个约束臂。 约束臂具有第一位置，其中约束臂基本上平行并且基本上邻近支撑表面。 此外，约束臂的至少一部分可从支撑表面移动到第二位置，其中约束臂可操作以约束单个电池。
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3.发明申请APPARATUSES AND RELATED METHODS FOR DELIVERING BIOLOGICAL MATERIAL INTO A CELL 审中-公开用于将生物材料递送至细胞的装置和相关方法公开(公告)号：US20120295345A1
公开(公告)日：2012-11-22
申请号：US13475401
申请日：2012-05-18
CPC分类号： C12N15/89 , A01K2217/05 , C12M35/00
摘要： Systems, devices, and methods for protecting a biological material during delivery into a biological structure are provided. In one aspect, for example, a device for protecting and delivering a preselected biological material into a biological structure can include a lance operable to maintain a charge capable of associating a biological material thereto and at least one protective region formed on or in the lance, where the protective region protects the biological material during delivery into a biological structure.
摘要翻译： 提供了在递送到生物结构期间保护生物材料的系统，装置和方法。 在一个方面，例如，用于保护并将预选生物材料输送到生物结构中的装置可以包括可操作以保持能够将生物材料与其缔合的电荷与形成在喷枪上或其中的至少一个保护区域的喷枪， 其中保护区域在递送到生物结构期间保护生物材料。
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公开(公告)号：US20130177977A1
公开(公告)日：2013-07-11
申请号：US13539184
申请日：2012-06-29
申请人： Quentin T. Aten , Walter Fazio , Jason Mathew Lund , Gregory H. Teichert , Sandra H. Burnett , Brian D. Jensen , Larry L. Howell
发明人： Quentin T. Aten , Walter Fazio , Jason Mathew Lund , Gregory H. Teichert , Sandra H. Burnett , Brian D. Jensen , Larry L. Howell
摘要： Systems, devices, and methods for restraining a biological structure are provided. In one example, a biological structure restraining device can include a barrier structure, an opening defined in the barrier structure, and at least two contact points positioned adjacent to the opening and oriented to contact the biological structure, wherein the barrier structure and the opening are structurally positioned to receive the cell at the contact points. In another aspect, the device can also include a biological structure manipulator having a structure operable to press the biological structure against the contact points. In yet another aspect, the device can further include a biological structure injector having a structure operable to be inserted through the opening and into the biological structure, wherein the biological structure manipulator is operable to maintain the biological structure against the contact points as the biological structure injector is inserted into the biological structure.
摘要翻译： 提供了用于抑制生物结构的系统，装置和方法。 在一个实例中，生物结构抑制装置可以包括阻挡结构，限定在阻挡结构中的开口，以及至少两个位于邻近开口定位并接触生物结构的接触点，其中阻挡结构和开口是 在结构上定位为在接触点处接收电池。 在另一方面，该装置还可以包括生物结构操纵器，其具有可操作地抵抗接触点按压生物结构的结构。 在另一方面，该装置还可以包括生物结构注射器，该生物结构注射器具有可操作地插入穿过开口并进入生物结构的结构，其中生物结构操纵器可操作以将生物结构保持抵抗接触点作为生物结构 注射器插入生物结构。
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5.发明申请Lance Device and Associated Methods for Delivering a Biological Material Into a Cell 审中-公开喷枪装置和将生物材料递送到细胞中的相关方法公开(公告)号：US20120301960A1
公开(公告)日：2012-11-29
申请号：US13480083
申请日：2012-05-24
摘要： Systems, devices, and methods for delivering a biological material into a cell are provided. In one example, a lance device for introducing biological material into a cell and configured for use in a nanoinjection system including a microscope is provided. Such a device can include a lance having a tip region and a shaft region, wherein the lance is structurally configured to allow entry and movement of the tip region into the cell along an elongate axis of the tip region and along a focal plane of the microscope. In another example, the lance can be configured to allow substantially horizontal entry and movement of the tip region into the cell.
摘要翻译： 提供了将生物材料递送到电池中的系统，装置和方法。 在一个示例中，提供了用于将生物材料引入细胞并配置用于包括显微镜的纳米注射系统中的喷枪装置。 这种装置可以包括具有尖端区域和轴区域的喷枪，其中喷枪在结构上构造成允许尖端区域沿着尖端区域的细长轴线并沿着显微镜的焦平面进入和移动到细胞中 。 在另一示例中，喷枪可以被配置为允许尖端区域基本上水平地进入和移动到电池中。
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公开(公告)号：US20130005040A1
公开(公告)日：2013-01-03
申请号：US13456856
申请日：2012-04-26
CPC分类号： C12N15/85 , A01K2217/05 , C12N13/00 , C12N15/89
摘要： Systems, devices, and methods for delivering a biological material into an organelle of a cell are provided. In one aspect, for example, a method for introducing biological material into an organelle of a cell includes bringing into proximity a lance and a preselected biological material outside of a cell and charging the lance with a polarity and a charge sufficient to electrically associate the preselected biological material with a tip portion of the lance. The method also includes penetrating an outer portion of the cell with the lance and directing and inserting the lance into an organelle, discharging the lance to release at least a portion of the biological material into the organelle, and withdrawing the lance from the cell.
摘要翻译： 提供了将生物材料递送到细胞的细胞器中的系统，装置和方法。 在一个方面，例如，将生物材料引入细胞的细胞器中的方法包括将细胞附近的喷枪和预先选择的生物材料接近，并以足以使预选的电极相互关联的极性和电荷充入喷枪 具有喷枪尖端部分的生物材料。 该方法还包括用喷枪穿透细胞的外部部分并将喷枪引导并插入细胞器中，排出喷枪以将生物材料的至少一部分释放到细胞器中，并将细胞器从细胞中取出。
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公开(公告)号：US06215081B1
公开(公告)日：2001-04-10
申请号：US09280916
申请日：1999-03-29
IPC分类号： H01H300
CPC分类号： H01H3/46 , H01H1/0036 , H01H2003/466
摘要： A compliant, bistable mechanism has a plurality of segments coupled end-to-end in a series to form a continuous chain of segments. The plurality of segments includes at least two rigid segments and at least one relatively flexible and resilient segment. Adjacent rigid segments are coupled by flexible joints or pin joints. The flexible and resilient segment is coupled to adjacent segments either fixedly or by pin joints. There are at least four pin joints, flexible joints, and/or flexible and resilient segments. The joints allow relative movement of the segments while the flexible and resilient segment resists movement and biases the segments. The segments move between first and second stable equilibrium positions. The segments have a pseudo-rigid-body model resembling a four-bar linkage. The segments and flexible joints may be integrally formed. First and second electrical contacts may be coupled to the segments to form an electrical connection as the segments move to one of the positions.
摘要翻译： 顺应的双稳态机构具有多个段，其以一系列端对端地连接以形成连续的段链。 多个段包括至少两个刚性段和至少一个相对柔性且弹性的段。 相邻的刚性段通过柔性接头或销接头联接。 柔性和弹性部分固定地或通过销接头联接到相邻的部分。 有至少四个针接头，柔性接头和/或柔性和弹性段。 接头允许片段的相对运动，而柔性和弹性片段抵抗运动并偏转片段。 段在第一和第二稳定平衡位置之间移动。 这些段具有类似于四连杆的伪刚体模型。 节段和柔性接头可以一体形成。 当所述段移动到所述位置中的一个时，第一和第二电触头可以联接到所述段以形成电连接。
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公开(公告)号：US07075209B2
公开(公告)日：2006-07-11
申请号：US10333302
申请日：2001-07-18
CPC分类号： H02N1/006 , B81C99/006 , F03G7/06 , H01H2001/0042
摘要： A method for designing and optimnizing compliant mechanisms is provided, in addition to bistable compliant mechanism designs. According to the method, a selected compliant structure may be modeled analytically, and the characteristics of the analytical model may be optimized. Multiple recursive optimization algorithms may be used, for example, to determine the general location of a global optimum, and then to determine the values of the analytical model characteristics that obtain the global optimum or a feasible configuration for the selected compliant structure. Geometric characteristics of the selected compliant structure may be derived from the values of the analytical model characteristics. Bistable compliant designs may have a shuttle disposed between a pair of base members. The shuttle (20) may be linked to the base members (22, 24) by a pair of legs (30, 32), via flexural pivots. The base members may have cantilevered mounting beams to create deformable mounts that receive and store potential energy. The stable configurations are those in which the stored potential energy is at a relative minimum.
摘要翻译： 提供了一种用于设计和优化顺应机制的方法，以及双稳态机构设计。 根据该方法，可以分析地对所选择的顺应性结构进行建模，并且可以优化分析模型的特性。 可以使用多个递归优化算法，例如，以确定全局最优值的一般位置，然后确定获得所选顺应结构的全局最优值或可行配置的分析模型特征值。 可以从分析模型特征的值导出所选顺应性结构的几何特征。 双稳态兼容设计可以具有布置在一对基座构件之间的梭子。 梭子（20）可以通过弯曲枢轴通过一对腿（30,32）连接到基部构件（22,24）。 基部构件可以具有悬臂安装梁，以产生可接收和存储势能的可变形安装件。 稳定的结构是其中存储的势能处于相对最小值的构型。
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公开(公告)号：US06983924B2
公开(公告)日：2006-01-10
申请号：US10258568
申请日：2001-04-25
申请人： Larry L. Howell , Scott Thomson , Jason Alan Briscoe , John J. Parise , Shae Lorenc , John B. Larsen , Curtis R. Huffmire , Nathan Burnside , Troy A. Gomm
发明人： Larry L. Howell , Scott Thomson , Jason Alan Briscoe , John J. Parise , Shae Lorenc , John B. Larsen , Curtis R. Huffmire , Nathan Burnside , Troy A. Gomm
IPC分类号： F16F1/34
CPC分类号： F16F3/023 , F16F1/027 , F16F1/324 , F16F3/026 , F16F15/073 , F16F2236/027 , Y10S251/902
摘要： An ortho-planar spring has a platform movably coupled to a base and being movable linearly with respect to the base along at least a portion of an axial direction perpendicular to both a base surface and a platform surface. A resilient and flexible connecting structure is connected to and between the base and platform. The connecting structure is bendable to develop (i) an axial force along the axial direction to bias the platform in a stable position with respect to the base, and (ii) non-axial forces which substantially sum to zero to preserve the orientation of the platform with respect to the base. Thus, the spring is very compact and does not have rotation between the deflecting ends. The spring may be associated with a valve opening, and a button for restricting flow through the valve opening, to bias the button at a position with respect to the valve opening.
摘要翻译： 正平面弹簧具有可移动地联接到基座的平台，并且可沿着垂直于基部表面和平台表面的轴向方向的至少一部分相对于基座线性移动。 弹性和柔性的连接结构连接到基座和平台之间。 连接结构是可弯曲的，以形成（i）沿轴向方向的轴向力，以将平台偏置在相对于基座的稳定位置，以及（ii）非轴向力，其基本上总和为零以保持 平台相对于基地。 因此，弹簧非常紧凑，并且在偏转端之间不具有旋转。 弹簧可以与阀开口相关联，以及用于限制流过阀开口的按钮，以将按钮偏置在相对于阀开口的位置。
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公开(公告)号：US06734597B1
公开(公告)日：2004-05-11
申请号：US10312172
申请日：2002-12-18
申请人： Larry L. Howell , Scott Lyon
发明人： Larry L. Howell , Scott Lyon
IPC分类号： H02N1000
CPC分类号： H01H1/0036 , B81B3/0037 , B81B2201/031 , B81B2203/0109 , B81B2203/051 , F03G7/06 , H01H61/00 , H01H2061/006 , H02N10/00
摘要： A microactuator providing an output force and displacement in response to an increase in thermal energy is displosed. The microactuator may have a substantially straight expansion member with a first and a second end. The first end may be coupled to a base member, and the second end may be coupled to a shuttle. The expansion member is capable of elongating in a elongation direction. Elongation of the expansion member may urge the shuttle to translate in an output direction substantially different than the elongation direction. In certain embodiments, multiple expansion members are arrayed along one side of the shuttle to drive the shuttle against a surface. Alternatively, expansion members may be disposed on both sides of the shuttle to provide balanced output force. If desired, multiple microactuators may be linked together to multiply the output displacement and/or output force.
摘要翻译： 提供响应于热能增加的输出力和位移的微致动器被消除。 微致动器可以具有基本上直的膨胀构件，其具有第一和第二端。 第一端可以联接到基座构件，并且第二端可以联接到梭子。 膨胀构件能够在伸长方向上伸长。 膨胀构件的伸长可以促使梭在基本上不同于伸长方向的输出方向上平移。 在某些实施例中，多个膨胀构件沿梭子的一侧排列以驱动穿梭件抵靠表面。 或者，扩展构件可以设置在梭子的两侧以提供平衡的输出力。 如果需要，多个微致动器可以连接在一起以乘以输出位移和/或输出力。
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