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    Systems and Devices for Restraining a Cell and Associated Methods
    1.
    发明申请
    Systems and Devices for Restraining a Cell and Associated Methods 审中-公开
    用于限制细胞和相关方法的系统和装置

    公开(公告)号：US20130177977A1

    公开(公告)日：2013-07-11

    申请号：US13539184

    申请日：2012-06-29

    申请人： Quentin T. Aten ,  Walter Fazio ,  Jason Mathew Lund ,  Gregory H. Teichert ,  Sandra H. Burnett ,  Brian D. Jensen ,  Larry L. Howell

    发明人： Quentin T. Aten ,  Walter Fazio ,  Jason Mathew Lund ,  Gregory H. Teichert ,  Sandra H. Burnett ,  Brian D. Jensen ,  Larry L. Howell

    IPC分类号： C12M1/12 ,  C12N15/89

    CPC分类号： C12M25/00 ,  C12M23/12 ,  C12M35/00 ,  C12N15/89

    摘要： Systems, devices, and methods for restraining a biological structure are provided. In one example, a biological structure restraining device can include a barrier structure, an opening defined in the barrier structure, and at least two contact points positioned adjacent to the opening and oriented to contact the biological structure, wherein the barrier structure and the opening are structurally positioned to receive the cell at the contact points. In another aspect, the device can also include a biological structure manipulator having a structure operable to press the biological structure against the contact points. In yet another aspect, the device can further include a biological structure injector having a structure operable to be inserted through the opening and into the biological structure, wherein the biological structure manipulator is operable to maintain the biological structure against the contact points as the biological structure injector is inserted into the biological structure.

    摘要翻译： 提供了用于抑制生物结构的系统，装置和方法。 在一个实例中，生物结构抑制装置可以包括阻挡结构，限定在阻挡结构中的开口，以及至少两个位于邻近开口定位并接触生物结构的接触点，其中阻挡结构和开口是 在结构上定位为在接触点处接收电池。 在另一方面，该装置还可以包括生物结构操纵器，其具有可操作地抵抗接触点按压生物结构的结构。 在另一方面，该装置还可以包括生物结构注射器，该生物结构注射器具有可操作地插入穿过开口并进入生物结构的结构，其中生物结构操纵器可操作以将生物结构保持抵抗接触点作为生物结构 注射器插入生物结构。

    Delivery of Biological Materials Into Cellular Organelles
    3.
    发明申请
    Delivery of Biological Materials Into Cellular Organelles 审中-公开
    将生物材料交付给细胞器

    公开(公告)号：US20130005040A1

    公开(公告)日：2013-01-03

    申请号：US13456856

    申请日：2012-04-26

    申请人： Quentin T. Aten ,  Sandra H. Burnett ,  Brian D. Jensen ,  Larry L. Howell

    发明人： Quentin T. Aten ,  Sandra H. Burnett ,  Brian D. Jensen ,  Larry L. Howell

    IPC分类号： C12N15/89 ,  C12M1/00

    CPC分类号： C12N15/85 ,  A01K2217/05 ,  C12N13/00 ,  C12N15/89

    摘要： Systems, devices, and methods for delivering a biological material into an organelle of a cell are provided. In one aspect, for example, a method for introducing biological material into an organelle of a cell includes bringing into proximity a lance and a preselected biological material outside of a cell and charging the lance with a polarity and a charge sufficient to electrically associate the preselected biological material with a tip portion of the lance. The method also includes penetrating an outer portion of the cell with the lance and directing and inserting the lance into an organelle, discharging the lance to release at least a portion of the biological material into the organelle, and withdrawing the lance from the cell.

    摘要翻译： 提供了将生物材料递送到细胞的细胞器中的系统，装置和方法。 在一个方面，例如，将生物材料引入细胞的细胞器中的方法包括将细胞附近的喷枪和预先选择的生物材料接近，并以足以使预选的电极相互关联的极性和电荷充入喷枪 具有喷枪尖端部分的生物材料。 该方法还包括用喷枪穿透细胞的外部部分并将喷枪引导并插入细胞器中，排出喷枪以将生物材料的至少一部分释放到细胞器中，并将细胞器从细胞中取出。

    Lance Device and Associated Methods for Delivering a Biological Material Into a Cell
    4.
    发明申请
    Lance Device and Associated Methods for Delivering a Biological Material Into a Cell 审中-公开
    喷枪装置和将生物材料递送到细胞中的相关方法

    公开(公告)号：US20120301960A1

    公开(公告)日：2012-11-29

    申请号：US13480083

    申请日：2012-05-24

    申请人： Quentin T. Aten ,  Sandra H. Burnett ,  Brian D. Jensen ,  Larry L. Howell

    发明人： Quentin T. Aten ,  Sandra H. Burnett ,  Brian D. Jensen ,  Larry L. Howell

    IPC分类号： C12M1/00 ,  C12N5/071

    CPC分类号： C12N15/89 ,  C12M35/00

    摘要： Systems, devices, and methods for delivering a biological material into a cell are provided. In one example, a lance device for introducing biological material into a cell and configured for use in a nanoinjection system including a microscope is provided. Such a device can include a lance having a tip region and a shaft region, wherein the lance is structurally configured to allow entry and movement of the tip region into the cell along an elongate axis of the tip region and along a focal plane of the microscope. In another example, the lance can be configured to allow substantially horizontal entry and movement of the tip region into the cell.

    摘要翻译： 提供了将生物材料递送到电池中的系统，装置和方法。 在一个示例中，提供了用于将生物材料引入细胞并配置用于包括显微镜的纳米注射系统中的喷枪装置。 这种装置可以包括具有尖端区域和轴区域的喷枪，其中喷枪在结构上构造成允许尖端区域沿着尖端区域的细长轴线并沿着显微镜的焦平面进入和移动到细胞中 。 在另一示例中，喷枪可以被配置为允许尖端区域基本上水平地进入和移动到电池中。