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公开(公告)号：US20130177977A1
公开(公告)日：2013-07-11
申请号：US13539184
申请日：2012-06-29
申请人： Quentin T. Aten , Walter Fazio , Jason Mathew Lund , Gregory H. Teichert , Sandra H. Burnett , Brian D. Jensen , Larry L. Howell
发明人： Quentin T. Aten , Walter Fazio , Jason Mathew Lund , Gregory H. Teichert , Sandra H. Burnett , Brian D. Jensen , Larry L. Howell
摘要： Systems, devices, and methods for restraining a biological structure are provided. In one example, a biological structure restraining device can include a barrier structure, an opening defined in the barrier structure, and at least two contact points positioned adjacent to the opening and oriented to contact the biological structure, wherein the barrier structure and the opening are structurally positioned to receive the cell at the contact points. In another aspect, the device can also include a biological structure manipulator having a structure operable to press the biological structure against the contact points. In yet another aspect, the device can further include a biological structure injector having a structure operable to be inserted through the opening and into the biological structure, wherein the biological structure manipulator is operable to maintain the biological structure against the contact points as the biological structure injector is inserted into the biological structure.
摘要翻译： 提供了用于抑制生物结构的系统，装置和方法。 在一个实例中，生物结构抑制装置可以包括阻挡结构，限定在阻挡结构中的开口，以及至少两个位于邻近开口定位并接触生物结构的接触点，其中阻挡结构和开口是 在结构上定位为在接触点处接收电池。 在另一方面，该装置还可以包括生物结构操纵器，其具有可操作地抵抗接触点按压生物结构的结构。 在另一方面，该装置还可以包括生物结构注射器，该生物结构注射器具有可操作地插入穿过开口并进入生物结构的结构，其中生物结构操纵器可操作以将生物结构保持抵抗接触点作为生物结构 注射器插入生物结构。
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2.发明申请APPARATUSES AND RELATED METHODS FOR DELIVERING BIOLOGICAL MATERIAL INTO A CELL 审中-公开用于将生物材料递送至细胞的装置和相关方法公开(公告)号：US20120295345A1
公开(公告)日：2012-11-22
申请号：US13475401
申请日：2012-05-18
CPC分类号： C12N15/89 , A01K2217/05 , C12M35/00
摘要： Systems, devices, and methods for protecting a biological material during delivery into a biological structure are provided. In one aspect, for example, a device for protecting and delivering a preselected biological material into a biological structure can include a lance operable to maintain a charge capable of associating a biological material thereto and at least one protective region formed on or in the lance, where the protective region protects the biological material during delivery into a biological structure.
摘要翻译： 提供了在递送到生物结构期间保护生物材料的系统，装置和方法。 在一个方面，例如，用于保护并将预选生物材料输送到生物结构中的装置可以包括可操作以保持能够将生物材料与其缔合的电荷与形成在喷枪上或其中的至少一个保护区域的喷枪， 其中保护区域在递送到生物结构期间保护生物材料。
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公开(公告)号：US20130005040A1
公开(公告)日：2013-01-03
申请号：US13456856
申请日：2012-04-26
CPC分类号： C12N15/85 , A01K2217/05 , C12N13/00 , C12N15/89
摘要： Systems, devices, and methods for delivering a biological material into an organelle of a cell are provided. In one aspect, for example, a method for introducing biological material into an organelle of a cell includes bringing into proximity a lance and a preselected biological material outside of a cell and charging the lance with a polarity and a charge sufficient to electrically associate the preselected biological material with a tip portion of the lance. The method also includes penetrating an outer portion of the cell with the lance and directing and inserting the lance into an organelle, discharging the lance to release at least a portion of the biological material into the organelle, and withdrawing the lance from the cell.
摘要翻译： 提供了将生物材料递送到细胞的细胞器中的系统，装置和方法。 在一个方面，例如，将生物材料引入细胞的细胞器中的方法包括将细胞附近的喷枪和预先选择的生物材料接近，并以足以使预选的电极相互关联的极性和电荷充入喷枪 具有喷枪尖端部分的生物材料。 该方法还包括用喷枪穿透细胞的外部部分并将喷枪引导并插入细胞器中，排出喷枪以将生物材料的至少一部分释放到细胞器中，并将细胞器从细胞中取出。
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4.发明申请Lance Device and Associated Methods for Delivering a Biological Material Into a Cell 审中-公开喷枪装置和将生物材料递送到细胞中的相关方法公开(公告)号：US20120301960A1
公开(公告)日：2012-11-29
申请号：US13480083
申请日：2012-05-24
摘要： Systems, devices, and methods for delivering a biological material into a cell are provided. In one example, a lance device for introducing biological material into a cell and configured for use in a nanoinjection system including a microscope is provided. Such a device can include a lance having a tip region and a shaft region, wherein the lance is structurally configured to allow entry and movement of the tip region into the cell along an elongate axis of the tip region and along a focal plane of the microscope. In another example, the lance can be configured to allow substantially horizontal entry and movement of the tip region into the cell.
摘要翻译： 提供了将生物材料递送到电池中的系统，装置和方法。 在一个示例中，提供了用于将生物材料引入细胞并配置用于包括显微镜的纳米注射系统中的喷枪装置。 这种装置可以包括具有尖端区域和轴区域的喷枪，其中喷枪在结构上构造成允许尖端区域沿着尖端区域的细长轴线并沿着显微镜的焦平面进入和移动到细胞中 。 在另一示例中，喷枪可以被配置为允许尖端区域基本上水平地进入和移动到电池中。
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公开(公告)号：US20100323419A1
公开(公告)日：2010-12-23
申请号：US12668369
申请日：2008-07-09
摘要： Systems and methods for manipulating molecular material are provided. In one aspect, for example, a method for manipulating molecular material may include positioning an uncharged needle structure in electrical proximity with a charged molecular material at a first locus in a liquid environment, charging the needle structure such that at least a portion of the charged molecular material becomes associated with the needle structure, moving the needle structure and the first locus relative to one another, and discharging the needle structure to disassociate the charged molecular material at a second locus.
摘要翻译： 提供了操作分子材料的系统和方法。 在一个方面，例如，用于操纵分子材料的方法可以包括在液体环境中的第一位置处将不带电的针结构定位成与电荷分子材料电接近，对针结构进行充电，使得至少一部分带电 分子材料与针结构相关联，使针结构和第一轨迹相对移动，并且排出针结构以在第二位置分离带电分子材料。
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公开(公告)号：US20100248343A1
公开(公告)日：2010-09-30
申请号：US12816183
申请日：2010-06-15
IPC分类号： C12M1/00
摘要： Devices and methods for constraining or holding a cell are provided. In one aspect, for example, a cellular constraint device is provided. Such a device can include a support surface and at least one constraining arm movably coupled to the support surface. The constraining arm has a first position in which the constraining arm is substantially parallel and substantially adjacent to the support surface. Additionally, at least a portion of the constraining arm is movable away from the support surface to a second position where the constraining arm is operable to constrain a single cell.
摘要翻译： 提供了用于约束或保持单元的装置和方法。 在一个方面，例如，提供了一种蜂窝约束装置。 这种装置可以包括支撑表面和可移动地联接到支撑表面的至少一个约束臂。 约束臂具有第一位置，其中约束臂基本上平行并且基本上邻近支撑表面。 此外，约束臂的至少一部分可从支撑表面移动到第二位置，其中约束臂可操作以约束单个电池。
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