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公开(公告)号：US11514586B1
公开(公告)日：2022-11-29
申请号：US17817248
申请日：2022-08-03
申请人： Protochips, Inc.
发明人： Franklin Stampley Walden, II , John Damiano, Jr. , David P. Nackashi , Daniel Stephen Gardiner , Mark Uebel , Alan Philip Franks , Benjamin Jacobs , Joshua Brian Friend , Katherine Elizabeth Marusak , Nelson L Marthe, Jr. , Benjamin Bradshaw Larson
摘要： Methods and systems for calibrating a transmission electron microscope are disclosed. A fiducial mark on the sample holder is used to identify known reference points so that a current collection area and a through-hole on the sample holder can be located. A plurality of beam current and beam area measurements are taken, and calibration tables are extrapolated from the measurements for a full range of microscope parameters. The calibration tables are then used to determine electron dose of a sample during an experiment at a given configuration.
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公开(公告)号：US10986279B1
公开(公告)日：2021-04-20
申请号：US16951297
申请日：2020-11-18
申请人： Protochips, Inc.
发明人： Franklin Stampley Walden, II , John Damiano, Jr. , David P. Nackashi , Daniel Stephen Gardiner , Mark Uebel , Alan Philip Franks , Benjamin Jacobs
摘要： Control system configured for sample tracking in an electron microscope environment registers a movement associated with a region of interest located within an active area of a sample under observation with an electron microscope. The registered movement includes at least one directional constituent. The region of interest is positioned within a field of view of the electron microscope. The control system directs an adjustment of the electron microscope control component to one or more of dynamically center and dynamically focus the view through the electron microscope of the region of interest. The adjustment comprises one or more of a magnitude element and a direction element.
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公开(公告)号：US20180203423A1
公开(公告)日：2018-07-19
申请号：US15919575
申请日：2018-03-13
申请人： PROTOCHIPS, INC.
发明人： Daniel S. Gardiner , John Damiano, JR. , David P. Nackashi , William Bradford Carpenter , James Rivenbark , Mark Uebel , Michael Zapata, III , Rebecca Thomas , Franklin Stampley Walden, II
CPC分类号： G05B9/02 , G01M3/3272 , G05D7/0635 , H01J37/18 , H01J37/20 , H01J2237/006 , H01J2237/182 , H01J2237/2002 , H01J2237/2007 , H01J2237/2802
摘要： System and method for safely controlling the containment of gas within a manifold system and the delivery of gas to a sample holder for an electron microscope for imaging and analysis.
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公开(公告)号：US11477388B2
公开(公告)日：2022-10-18
申请号：US17545651
申请日：2021-12-08
申请人： Protochips, Inc.
发明人： Franklin Stampley Walden, II , John Damiano, Jr. , David P. Nackashi , Daniel Stephen Gardiner , Mark Uebel , Alan Philip Franks , Benjamin Jacobs
摘要： Control system configured for sample tracking in an electron microscope environment registers a movement associated with a region of interest located within an active area of a sample under observation with an electron microscope. The registered movement includes at least one directional constituent. The region of interest is positioned within a field of view of the electron microscope. The control system directs an adjustment of the electron microscope control component to one or more of dynamically center and dynamically focus the view through the electron microscope of the region of interest. The adjustment comprises one or more of a magnitude element and a direction element.
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公开(公告)号：US20210112203A1
公开(公告)日：2021-04-15
申请号：US16951297
申请日：2020-11-18
申请人： Protochips, Inc.
发明人： Franklin Stampley Walden, II , John Damiano, JR. , David P. Nackashi , Daniel Stephen Gardiner , Mark Uebel , Alan Philip Franks , Benjamin Jacobs
摘要： Control system configured for sample tracking in an electron microscope environment registers a movement associated with a region of interest located within an active area of a sample under observation with an electron microscope. The registered movement includes at least one directional constituent. The region of interest is positioned within a field of view of the electron microscope. The control system directs an adjustment of the electron microscope control component to one or more of dynamically center and dynamically focus the view through the electron microscope of the region of interest. The adjustment comprises one or more of a magnitude element and a direction element.
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公开(公告)号：US12130858B2
公开(公告)日：2024-10-29
申请号：US18244587
申请日：2023-09-11
申请人： Protochips, Inc.
发明人： Franklin Stampley Walden, II , John Damiano, Jr. , David P. Nackashi , Daniel Stephen Gardiner , Mark Uebel , Alan Philip Franks , Joshua Friend , Katherine Elizabeth Marusak
IPC分类号： A61B6/00 , G06F16/51 , G06F16/535 , G06F16/538 , G06F16/58 , G06T1/00 , G06T7/20 , G06T11/60
CPC分类号： G06F16/535 , G06F16/51 , G06F16/538 , G06F16/5866 , G06T1/0007 , G06T7/20 , G06T11/60 , G06T2200/24 , G06T2207/10061
摘要： Disclosed herein are methods and systems of metadata management for reviewing data from microscopy experimental sessions. Image data from an experimental session is stored in an archive at one or more filepath locations, either locally or on a network. Metadata associated with the image data is stored in a database with a reference to the filepath where the raw image is stored, such that the metadata is associated in the database with the image data. A user can perform post-experimental filtering, sorting, and searching of the underlying image data using the metadata, which allows the image data to be analyzed without duplication of the image data and without manual review of each individual image. The filtered data is presented in an interactive timeline format.
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7.发明公开公开(公告)号：US20230418863A1
公开(公告)日：2023-12-28
申请号：US18244587
申请日：2023-09-11
申请人： Protochips, Inc.
发明人： Franklin Stampley Walden, II , John Damiano, JR. , David P. Nackashi , Daniel Stephen Gardiner , Mark Uebel , Alan Philip Franks , Joshua Friend , Katherine Elizabeth Marusak
IPC分类号： G06F16/535 , G06T1/00 , G06T11/60 , G06T7/20 , G06F16/538 , G06F16/58 , G06F16/51
CPC分类号： G06F16/535 , G06T1/0007 , G06T11/60 , G06T7/20 , G06F16/538 , G06F16/5866 , G06F16/51 , G06T2207/10061 , G06T2200/24
摘要： Disclosed herein are methods and systems of metadata management for reviewing data from microscopy experimental sessions. Image data from an experimental session is stored in an archive at one or more filepath locations, either locally or on a network. Metadata associated with the image data is stored in a database with a reference to the filepath where the raw image is stored, such that the metadata is associated in the database with the image data. A user can perform post-experimental filtering, sorting, and searching of the underlying image data using the metadata, which allows the image data to be analyzed without duplication of the image data and without manual review of each individual image. The filtered data is presented in an interactive timeline format.
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公开(公告)号：US20230049691A1
公开(公告)日：2023-02-16
申请号：US17931466
申请日：2022-09-12
申请人： Protochips, Inc.
发明人： Franklin Stampley Walden, II , John Damiano, JR. , David P. Nackashi , Daniel Stephen Gardiner , Mark Uebel , Alan Philip Franks , Joshua Friend , Katherine Elizabeth Marusak
IPC分类号： G06F16/535 , G06T1/00 , G06T11/60 , G06T7/20 , G06F16/538 , G06F16/58 , G06F16/51
摘要： Disclosed herein are methods and systems of metadata management for reviewing data from microscopy experimental sessions. Image data from an experimental session is stored in an archive at one or more filepath locations, either locally or on a network. Metadata associated with the image data is stored in a database with a reference to the filepath where the raw image is stored, such that the metadata is associated in the database with the image data. A user can perform post-experimental filtering, sorting, and searching of the underlying image data using the metadata, which allows the image data to be analyzed without duplication of the image data and without manual review of each individual image. The filtered data is presented in an interactive timeline format.
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公开(公告)号：US20220327156A1
公开(公告)日：2022-10-13
申请号：US17715831
申请日：2022-04-07
申请人： Protochips, Inc.
发明人： Franklin Stampley Walden, II , John Damiano, JR. , David P. Nackashi , Daniel Stephen Gardiner , Mark Uebel , Alan Philip Franks , Joshua Friend , Katherine Elizabeth Marusak
IPC分类号： G06F16/535 , G06T1/00 , G06T11/60 , G06T7/20 , G06F16/51 , G06F16/538 , G06F16/58
摘要： Disclosed herein are methods and systems of metadata management for reviewing data from microscopy experimental sessions. Image data from an experimental session is stored in an archive at one or more filepath locations, either locally or on a network. Metadata associated with the image data is stored in a database with a reference to the filepath where the raw image is stored, such that the metadata is associated in the database with the image data. A user can perform post-experimental filtering, sorting, and searching of the underlying image data using the metadata, which allows the image data to be analyzed without duplication of the image data and without manual review of each individual image. The filtered data is presented in an interactive timeline format.
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公开(公告)号：US11455333B1
公开(公告)日：2022-09-27
申请号：US17715831
申请日：2022-04-07
申请人： Protochips, Inc.
发明人： Franklin Stampley Walden, II , John Damiano, Jr. , David P. Nackashi , Daniel Stephen Gardiner , Mark Uebel , Alan Philip Franks , Joshua Friend , Katherine Elizabeth Marusak
IPC分类号： G06K9/00 , G06F16/535 , G06T1/00 , G06T11/60 , G06T7/20 , G06F16/538 , G06F16/58 , G06F16/51
摘要： Disclosed herein are methods and systems of metadata management for reviewing data from microscopy experimental sessions. Image data from an experimental session is stored in an archive at one or more filepath locations, either locally or on a network. Metadata associated with the image data is stored in a database with a reference to the filepath where the raw image is stored, such that the metadata is associated in the database with the image data. A user can perform post-experimental filtering, sorting, and searching of the underlying image data using the metadata, which allows the image data to be analyzed without duplication of the image data and without manual review of each individual image. The filtered data is presented in an interactive timeline format.
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