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1.发明授权Fermentation process using specific oxygen uptake rates as a process control 有权使用特定氧气摄取速率的发酵过程作为过程控制公开(公告)号：US08828707B2
公开(公告)日：2014-09-09
申请号：US13078128
申请日：2011-04-01
申请人： Pim Van Hoek , Aristos Aristidou , Brian Rush
发明人： Pim Van Hoek , Aristos Aristidou , Brian Rush
CPC分类号： C12P7/56 , C12N1/16 , C12N9/0006 , C12N15/815 , C12P7/625 , C12Q1/02 , G01N2333/39 , Y02P20/52
摘要： Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of a fermentation process, and process parameters are adjusted to maintain the OUR within desired ranges. The invention is particularly applicable when the fermentation is conducted using a microorganism having a natural PDC pathway that has been disrupted so that it no longer functions. Microorganisms of this sort often produce poorly under strictly anaerobic conditions. Microaeration controlled by monitoring OUR allows the performance of the microorganism to be optimized.
摘要翻译： 比氧吸收（OUR）用作发酵过程中的过程控制参数。 在至少在发酵过程的生产阶段确定OUR，并调整工艺参数以将OUR保持在所需范围内。 当使用已经被破坏的天然PDC途径的微生物进行发酵以使其不再起作用时，本发明特别适用。 这种微生物在严格的无氧条件下往往产生不良。 通过监测OUR控制的微量曝气允许优化微生物的性能。
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公开(公告)号：US07232664B2
公开(公告)日：2007-06-19
申请号：US10449911
申请日：2003-05-30
申请人： Pim Van Hoek , Aristos Aristidou , Brian Rush
发明人： Pim Van Hoek , Aristos Aristidou , Brian Rush
CPC分类号： C12P7/56 , C12N1/16 , C12N9/0006 , C12N15/815 , C12P7/625 , C12Q1/02 , G01N2333/39 , Y02P20/52
摘要： Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of a fermentation process, and process parameters are adjusted to maintain the OUR within desired ranges. The invention is particularly applicable when the fermentation is conducted using a microorganism having a natural PDC pathway that has been disrupted so that it no longer functions. Microorganisms of this sort often produce poorly under strictly anaerobic conditions. Microaeration controlled by monitoring OUR allows the performance of the microorganism to be optimized.
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3.发明授权Fermentation process using specific oxygen uptake rates as a process control 有权使用特定氧气摄取速率的发酵过程作为过程控制公开(公告)号：US07939298B2
公开(公告)日：2011-05-10
申请号：US11707188
申请日：2007-02-14
申请人： Pim Van Hoek , Aristos Aristidou , Brian Rush
发明人： Pim Van Hoek , Aristos Aristidou , Brian Rush
CPC分类号： C12P7/56 , C12N1/16 , C12N9/0006 , C12N15/815 , C12P7/625 , C12Q1/02 , G01N2333/39 , Y02P20/52
摘要： Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of a fermentation process, and process parameters are adjusted to maintain the OUR within desired ranges. The invention is particularly applicable when the fermentation is conducted using a microorganism having a natural PDC pathway that has been disrupted so that it no longer functions. Microorganisms of this sort often produce poorly under strictly anaerobic conditions. Microaeration controlled by monitoring OUR allows the performance of the microorganism to be optimized.
摘要翻译： 比氧吸收（OUR）用作发酵过程中的过程控制参数。 在至少在发酵过程的生产阶段确定OUR，并调整工艺参数以将OUR保持在所需范围内。 当使用已经被破坏的天然PDC途径的微生物进行发酵以使其不再起作用时，本发明特别适用。 这种微生物在严格的无氧条件下往往产生不良。 通过监测OUR控制的微量曝气允许优化微生物的性能。
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4.发明申请Lactic Acid-Producing Yeast Cells Having Nonfunctional L- or D-Lactate:Ferricytochrome C Oxidoreductase Cells 有权具有非功能性L-或D-乳酸的乳酸生产酵母细胞：铁染色质C氧化还原酶细胞公开(公告)号：US20090253189A1
公开(公告)日：2009-10-08
申请号：US12093757
申请日：2006-11-17
申请人： Matthew Miller , Pirkko Suominen , Aristos Aristidou , Benjamin Matthew Hause , Pim Van Hoek , Catherine Asleson Dundon
发明人： Matthew Miller , Pirkko Suominen , Aristos Aristidou , Benjamin Matthew Hause , Pim Van Hoek , Catherine Asleson Dundon
CPC分类号： C12N9/0006 , C12P7/56 , C12Y101/02003
摘要： Yeast cells having an exogenous lactate dehydrogenase gene ae modified by reducing L- or D-lactate:ferricytochrome c oxidoreductase activity in the cell. This leads to reduced consumption of lactate by the cell and can increase overall lactate yields in a fermentation process. Cells having the reduced I, or D-lactate:ferricytochrome c oxidoreductase activity can be screened for by resistance to organic acids such as lactic or glycolic acid.
摘要翻译： 酵母细胞具有通过减少细胞中的L-或D-乳酸：铁染色体氧化还原酶活性而修饰的外源性乳酸脱氢酶基因。 这导致细胞对乳酸盐的消耗降低，并且可以增加发酵过程中的总体乳酸盐产量。 具有降低的I或D-乳酸：铁染色质c氧化还原酶活性的细胞可通过耐有机酸如乳酸或乙醇酸进行筛选。
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5.发明授权Lactic acid-producing yeast cells having nonfunctional L- or D-lactate:ferricytochrome C oxidoreductase cells 有权具有非功能性L-或D-乳酸的产酸酵母细胞：铁染色质C氧化还原酶细胞公开(公告)号：US08137953B2
公开(公告)日：2012-03-20
申请号：US12093757
申请日：2006-11-17
申请人： Matthew Miller , Pirkko Suominen , Aristos Aristidou , Benjamin Matthew Hause , Pim Van Hoek , Catherine Asleson Dundon
发明人： Matthew Miller , Pirkko Suominen , Aristos Aristidou , Benjamin Matthew Hause , Pim Van Hoek , Catherine Asleson Dundon
CPC分类号： C12N9/0006 , C12P7/56 , C12Y101/02003
摘要： Yeast cells having an exogenous lactate dehydrogenase gene ae modified by reducing L- or D-lactate:ferricytochrome c oxidoreductase activity in the cell. This leads to reduced consumption of lactate by the cell and can increase overall lactate yields in a fermentation process. Cells having the reduced L- or D-lactate:ferricytochrome c oxidoreductase activity can be screened for by resistance to organic acids such as lactic or glycolic acid.
摘要翻译： 酵母细胞具有通过减少细胞中的L-或D-乳酸：铁染色体氧化还原酶活性而修饰的外源性乳酸脱氢酶基因。 这导致细胞对乳酸盐的消耗降低，并且可以增加发酵过程中的总体乳酸盐产量。 具有降低的L-乳酸或D-乳酸：细胞色素C氧化还原酶活性的细胞可通过耐有机酸如乳酸或乙醇酸进行筛选。
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6.发明申请Fermentation process using specific oxygen uptake rates as a process control 有权使用特定氧气摄取速率的发酵过程作为过程控制公开(公告)号：US20070148748A1
公开(公告)日：2007-06-28
申请号：US11707188
申请日：2007-02-14
申请人： Pim Hoek , Aristos Aristidou , Brian Rush
发明人： Pim Hoek , Aristos Aristidou , Brian Rush
CPC分类号： C12P7/56 , C12N1/16 , C12N9/0006 , C12N15/815 , C12P7/625 , C12Q1/02 , G01N2333/39 , Y02P20/52
摘要： Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of a fermentation process, and process parameters are adjusted to maintain the OUR within desired ranges. The invention is particularly applicable when the fermentation is conducted using a microorganism having a natural PDC pathway that has been disrupted so that it no longer functions. Microorganisms of this sort often produce poorly under strictly anaerobic conditions. Microaeration controlled by monitoring OUR allows the performance of the microorganism to be optimized.
摘要翻译： 比氧吸收（OUR）用作发酵过程中的过程控制参数。 在至少在发酵过程的生产阶段确定OUR，并调整工艺参数以将OUR保持在所需范围内。 当使用已经被破坏的天然PDC途径的微生物进行发酵以使其不再起作用时，本发明特别适用。 这种微生物在严格的无氧条件下往往产生不良。 通过监测OUR控制的微量曝气允许优化微生物的性能。
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7.发明授权公开(公告)号：US08623633B2
公开(公告)日：2014-01-07
申请号：US13107882
申请日：2011-05-14
申请人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
发明人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
IPC分类号： C12N1/00
CPC分类号： C12P7/14 , C12N1/16 , C12N9/0006 , C12N9/1205 , C12N9/1217 , C12N9/248 , C12N9/88 , C12N9/92 , C12N15/81 , C12N15/815 , C12P7/06 , C12P7/56 , C12Y101/01009 , C12Y207/01017 , C12Y207/02003 , C12Y302/01037 , C12Y401/01001 , C12Y501/03002 , C12Y503/01005 , Y02E50/17 , Y02P20/52
摘要： Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.
摘要翻译： 酵母细胞用外源木糖异构酶基因转化。 另外的遗传修饰增强转化细胞将木糖发酵成乙醇或其它所需发酵产物的能力。 这些修饰包括非特异性或特异性醛糖还原酶基因的缺失，木糖醇脱氢酶基因的缺失和/或木酮糖激酶的过表达。
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8.发明申请Genetically Modified Yeast of the Species Issatchenkia Orientalis and Closely Related Species, and Fermentation Processes Using Same 审中-公开东方药物和密切相关物种的转基因酵母和使用相同的发酵过程公开(公告)号：US20120129230A1
公开(公告)日：2012-05-24
申请号：US13316044
申请日：2011-12-09
申请人： Pirkko Suominen , Aristos Aristidou , Merja Penttila , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
发明人： Pirkko Suominen , Aristos Aristidou , Merja Penttila , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
CPC分类号： C12P7/56 , C12N9/0006
摘要： Cells of the species Issatchenkia orientalis and closely related yeast species are transformed with a vector to introduce an exogenous lactate dehydrogenase gene. The cells produce lactic acid efficiently and are resistant at low pH, high lactate titer conditions.
摘要翻译： 用载体转化东方蓟马和密切相关酵母菌种的细胞，引入外源性乳酸脱氢酶基因。 细胞有效地产生乳酸并且在低pH，高乳酸盐滴度条件下具有抗性。
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9.发明授权公开(公告)号：US08097448B2
公开(公告)日：2012-01-17
申请号：US11921161
申请日：2006-05-30
申请人： Pirkko Suominen , Aristos Aristidou , Merja Pentilla , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
发明人： Pirkko Suominen , Aristos Aristidou , Merja Pentilla , Marja Ilmen , Laura Ruohonen , Kari Koivuranta , Kevin Roberg-Perez
CPC分类号： C12P7/56 , C12N9/0006
摘要： Cells of the species Issatchenkia orientalis and closely related yeast species are transformed with a vector to introduce an exogenous lactate dehydrogenase gene. The cells produce lactic acid efficiently and are resistant at low pH, high lactate titer conditions.
摘要翻译： 用载体转化东方蓟马和密切相关酵母菌种的细胞，引入外源性乳酸脱氢酶基因。 细胞有效地产生乳酸并且在低pH，高乳酸盐滴度条件下具有抗性。
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10.发明申请公开(公告)号：US20060234364A1
公开(公告)日：2006-10-19
申请号：US10554887
申请日：2004-05-03
申请人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Miller , Stacey Olson , Laura Ruohonen
发明人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Miller , Stacey Olson , Laura Ruohonen
CPC分类号： C12P7/14 , C12N1/16 , C12N9/0006 , C12N9/1205 , C12N9/1217 , C12N9/248 , C12N9/88 , C12N9/92 , C12N15/81 , C12N15/815 , C12P7/06 , C12P7/56 , C12Y101/01009 , C12Y207/01017 , C12Y207/02003 , C12Y302/01037 , C12Y401/01001 , C12Y501/03002 , C12Y503/01005 , Y02E50/17 , Y02P20/52
摘要： Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications', include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.
摘要翻译： 酵母细胞用外源木糖异构酶基因转化。 另外的遗传修饰增强转化细胞将木糖发酵成乙醇或其它所需发酵产物的能力。 这些修饰包括非特异性或特异性醛糖还原酶基因的缺失，木糖醇脱氢酶基因的缺失和/或木酮糖激酶的过表达。
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