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公开(公告)号:US09381205B2
公开(公告)日:2016-07-05
申请号:US14525442
申请日:2014-10-28
Applicant: Pfizer, Inc. , Stem CentRx, Inc.
Inventor: Marc Isaac Damelin , Kiran Manohar Khandke , Puja Sapra , Alexander John Bankovich , Scott J. Dylla
IPC: A61K39/395 , A61K31/704 , A61K47/48 , C07K16/30
CPC classification number: A61K47/6849 , A61K31/704 , A61K47/6807 , A61K47/6851 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/77
Abstract: The present invention provides for anti-EFNA4 antibody-drug conjugates and methods for preparing and using the same.
Abstract translation: 本发明提供抗EFNA4抗体 - 药物偶联物及其制备和使用方法。
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2.ANTI-IL-13 RECEPTOR ALPHA 2 ANTIBODIES AND ANTIBODY-DRUG CONJUGATES 审中-公开
Title translation: 抗IL-13受体ALPHA 2抗体和抗体药物联合公开(公告)号:US20150266962A1
公开(公告)日:2015-09-24
申请号:US14439897
申请日:2013-10-30
Applicant: PFIZER INC.
Inventor: Dangshe Ma , Fang Jin , Lioudmila Gennadievna Tchistiakova , Puja Sapra
IPC: C07K16/28 , G01N33/574 , A61K47/48
CPC classification number: C07K16/2866 , A61K47/6803 , A61K47/6845 , A61K47/6849 , A61K47/6889 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , G01N33/57492 , G01N2333/7155
Abstract: Disclosed herein are anti-IL-13-Rα2 antibodies and antibody drug conjugates and methods for preparing and using the same.
Abstract translation: 本文公开了抗IL-13-Rα2抗体和抗体药物共轭物及其制备和使用方法。
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公开(公告)号:US20180228769A1
公开(公告)日:2018-08-16
申请号:US15516780
申请日:2015-09-29
Applicant: Pfizer Inc.
Inventor: Puja Sapra , Boris Shor
CPC classification number: A61K31/40 , A61K31/166 , A61K31/337 , A61K31/4015 , A61K31/4025 , A61K45/06 , A61K47/6855 , A61K47/6857 , A61K2300/00 , A61P35/00
Abstract: This invention relates to combinations of an auristatin or an auristatin-based antibody-drug-conjugate (ADC) with second active agents including PI3K/mTOR inhibitors, MEK inhibitors, taxanes, or other anti-cancer agents, and methods of treating abnormal cell growth by administering these combinations to patients.
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4.
公开(公告)号:US20140127211A1
公开(公告)日:2014-05-08
申请号:US14073273
申请日:2013-11-06
Applicant: Pfizer Inc.
Inventor: Kenneth G. Geles , Yijie Gao , Puja Sapra , Lioudmila Gennadievna Tchistiakova , Bin-Bing Stephen Zhou
CPC classification number: A61K47/48569 , A61K39/395 , A61K39/3955 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6863 , A61K47/6867 , A61K47/6869 , A61K47/6889 , A61K2039/505 , C07K16/28 , C07K16/2866 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/3046 , C07K16/3061 , C07K16/3069 , C07K16/32 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/66 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94
Abstract: The present invention provides for anti-Notch3 antibodies, anti-Notch3 antibody-drug conjugates and methods for preparing and using the same.
Abstract translation: 本发明提供抗Notch3抗体,抗Notch3抗体 - 药物共轭物及其制备和使用方法。
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公开(公告)号:US09777070B2
公开(公告)日:2017-10-03
申请号:US14696663
申请日:2015-04-27
Applicant: Pfizer Inc. , AbbVie Stemcentrx LLC
Inventor: Marc Isaac Damelin , Puja Sapra , Alexander John Bankovich , Scott J. Dylla
CPC classification number: C07K16/40 , A61K47/6801 , A61K47/6803 , A61K47/6817 , A61K47/6847 , A61K47/6871 , A61K47/6889 , C07K16/30 , C07K2317/24 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/77 , C07K2317/92
Abstract: The present invention provides anti-PTK7 antibody-drug conjugates and methods for preparing and using the same.
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公开(公告)号:US09872922B2
公开(公告)日:2018-01-23
申请号:US15176452
申请日:2016-06-08
Applicant: PFIZER, INC. , ABBVIE STEMCENTRX LLC
Inventor: Marc Isaac Damelin , Kiran Manohar Khandke , Puja Sapra , Alexander John Bankovich , Scott J. Dylla
IPC: A61K39/395 , A61K47/48 , A61K31/704 , C07K16/30 , A61K47/68
CPC classification number: A61K47/6849 , A61K31/704 , A61K47/6807 , A61K47/6851 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/77
Abstract: The present invention provides for anti-EFNA4 antibody-drug conjugates and methods for preparing and using the same.
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公开(公告)号:US09828428B2
公开(公告)日:2017-11-28
申请号:US14439897
申请日:2013-10-30
Applicant: Pfizer Inc.
Inventor: Dangshe Ma , Fang Jin , Lioudmila Gennadievna Tchistiakova , Puja Sapra
IPC: C07K16/28 , A61K47/48 , G01N33/574 , A61K39/395 , A61K39/00
CPC classification number: C07K16/2866 , A61K47/6803 , A61K47/6845 , A61K47/6849 , A61K47/6889 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , G01N33/57492 , G01N2333/7155
Abstract: Disclosed herein are anti-IL-13-Rα2 antibodies and antibody drug conjugates and methods for preparing and using the same.
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公开(公告)号:US10689458B2
公开(公告)日:2020-06-23
申请号:US15356750
申请日:2016-11-21
Applicant: Pfizer Inc.
Inventor: Dangshe Ma , Frank Loganzo, Jr. , Kimberly Ann Marquette , Edmund Idris Graziani , Puja Sapra , Pavel Strop
Abstract: The present invention provides site specific HER2 antibody drug conjugates and methods for preparing and using the same.
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9.
公开(公告)号:US20170014526A1
公开(公告)日:2017-01-19
申请号:US15221049
申请日:2016-07-27
Applicant: Pfizer Inc.
Inventor: Kenneth G. Geles , Yijie Gao , Puja Sapra , Lioudmila Gennadievna Tchistiakova , Bin-Bing Stephen Zhou
CPC classification number: C07K16/3061 , A61K39/395 , A61K39/3955 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6863 , A61K47/6867 , A61K47/6869 , A61K47/6889 , A61K2039/505 , C07K16/28 , C07K16/2866 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/3046 , C07K16/3069 , C07K16/32 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/66 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94
Abstract: The present invention provides for anti-Notch3 antibodies, anti-Notch3 antibody-drug conjugates and methods for preparing and using the same.
Abstract translation: 本发明提供抗Notch3抗体,抗Notch3抗体 - 药物共轭物及其制备和使用方法。
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10.
公开(公告)号:US09433687B2
公开(公告)日:2016-09-06
申请号:US14073273
申请日:2013-11-06
Applicant: Pfizer Inc.
Inventor: Kenneth G. Geles , Yijie Gao , Puja Sapra , Lioudmila Gennadievna Tchistiakova , Bin-Bing Stephen Zhou
CPC classification number: A61K47/48569 , A61K39/395 , A61K39/3955 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6863 , A61K47/6867 , A61K47/6869 , A61K47/6889 , A61K2039/505 , C07K16/28 , C07K16/2866 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/3046 , C07K16/3061 , C07K16/3069 , C07K16/32 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/66 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94
Abstract: The present invention provides for anti-Notch3 antibodies, anti-Notch3 antibody-drug conjugates and methods for preparing and using the same.
Abstract translation: 本发明提供抗Notch3抗体,抗Notch3抗体 - 药物共轭物及其制备和使用方法。
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