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    Antibody to GDF8 and uses thereof
    7.
    发明授权
    Antibody to GDF8 and uses thereof 有权
    GDF8抗体及其用途

    公开(公告)号：US09409981B2

    公开(公告)日：2016-08-09

    申请号：US13791700

    申请日：2013-03-08

    Applicant: Pfizer Inc.

    Inventor： Edward Roland LaVallie ,  Lisa Anne Collins-Racie ,  Christopher John Corcoran ,  Lioudmila Gennadievna Tchistiakova ,  John Adam Nowak ,  Riyez Karim ,  Xiang-Yang Tan ,  Kimberly Ann Marquette ,  Geertruida Machteld Veldman

    IPC: A61K39/00 ,  A61K39/395 ,  C07K16/22

    CPC classification number: C07K16/22 ,  A61K39/395 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

    Abstract: The disclosure provides novel molecules related to growth and differentiation factor 8 (GDF8), in particular epitopes specific to GDF8 and other specific antagonists of GDF8 in particular anti GDF8 antibodies or antigen binding protein or fragment thereof which may inhibit GDF8 activity and signal in vitro and/or in vivo. The disclosure also provides for an immunoassay used to detect and quantitate GDF8. The disclosure also provides methods for diagnosing, preventing, ameliorating, and treating GDF8 associated disorders, e.g., degenerative orders of muscle, bone, and insulin metabolism. Finally, the disclosure provides pharmaceuticals for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

    Abstract translation: 本公开提供了与生长和分化因子8（GDF8）相关的新分子，特别是GDF8特异性表位和GDF8的其他特异性拮抗剂，特别是可以抑制GDF8活性和体外信号的抗GDF8抗体或其抗原结合蛋白或其片段， /或体内。 本公开还提供用于检测和定量GDF8的免疫测定。 本公开还提供了用于诊断，预防，改善和治疗GDF8相关疾病例如肌肉，骨骼和胰岛素代谢的退行性顺序的方法。 最后，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种疾病的药物。

    ANTIBODY TO GDF8 AND USES THEREOF
    8.
    发明申请
    ANTIBODY TO GDF8 AND USES THEREOF 审中-公开
    抗GDF8的抗体及其用途

    公开(公告)号：US20140023638A1

    公开(公告)日：2014-01-23

    申请号：US13791700

    申请日：2013-03-08

    Applicant: Pfizer Inc.

    Inventor： Edward Roland LaVallie ,  Lisa Anne Collins-Racie ,  Christopher John Corcoran ,  Lioudmila Gennadievna Tchistiakova ,  John Adam Nowak ,  Riyez Karim ,  Xiang-Yang Tan ,  Kimberly Ann Marquette ,  Geertruida Machteld Veldman

    IPC: C07K16/22

    CPC classification number: C07K16/22 ,  A61K39/395 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

    Abstract: The disclosure provides novel molecules related to growth and differentiation factor 8 (GDF8), in particular epitopes specific to GDF8 and other specific antagonists of GDF8 in particular anti GDF8 antibodies or antigen binding protein or fragment thereof which may inhibit GDF8 activity and signal in vitro and/or in vivo. The disclosure also provides for an immunoassay used to detect and quantitate GDF8. The disclosure also provides methods for diagnosing, preventing, ameliorating, and treating GDF8 associated disorders, e.g., degenerative orders of muscle, bone, and insulin metabolism. Finally, the disclosure provides pharmaceuticals for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

    Abstract translation: 本公开提供了与生长和分化因子8（GDF8）相关的新分子，特别是GDF8特异性表位和GDF8的其他特异性拮抗剂，特别是可以抑制GDF8活性和体外信号的抗GDF8抗体或其抗原结合蛋白或其片段， /或体内。 本公开还提供用于检测和定量GDF8的免疫测定。 本公开还提供了用于诊断，预防，改善和治疗GDF8相关疾病例如肌肉，骨骼和胰岛素代谢的退行性顺序的方法。 最后，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种疾病的药物。

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