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公开(公告)号：US11833216B2
公开(公告)日：2023-12-05
申请号：US18166774
申请日：2023-02-09
Applicant: Pfizer Inc.
Inventor： Andrea Therese Hooper , Kimberly Ann Marquette , Chakrapani Subramanyam , Hans-Peter Gerber , Chad Michael May
CPC classification number: A61K47/6803 , A61K47/6843 , A61P35/00 , C07K16/18 , A61K38/08 , A61K47/6811 , C07K2317/21 , C07K2317/33 , C07K2317/52 , C07K2317/565 , C07K2317/92
Abstract: The present invention provides antibodies and antibody-drug conjugates that bind to the extra domain B splice variant of fibronectin 1 and methods for preparing and using the same.
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公开(公告)号：US10689458B2
公开(公告)日：2020-06-23
申请号：US15356750
申请日：2016-11-21
Applicant: Pfizer Inc.
Inventor： Dangshe Ma , Frank Loganzo, Jr. , Kimberly Ann Marquette , Edmund Idris Graziani , Puja Sapra , Pavel Strop
Abstract: The present invention provides site specific HER2 antibody drug conjugates and methods for preparing and using the same.
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公开(公告)号：US09409981B2
公开(公告)日：2016-08-09
申请号：US13791700
申请日：2013-03-08
Applicant: Pfizer Inc.
Inventor： Edward Roland LaVallie , Lisa Anne Collins-Racie , Christopher John Corcoran , Lioudmila Gennadievna Tchistiakova , John Adam Nowak , Riyez Karim , Xiang-Yang Tan , Kimberly Ann Marquette , Geertruida Machteld Veldman
IPC: A61K39/00 , A61K39/395 , C07K16/22
CPC classification number: C07K16/22 , A61K39/395 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: The disclosure provides novel molecules related to growth and differentiation factor 8 (GDF8), in particular epitopes specific to GDF8 and other specific antagonists of GDF8 in particular anti GDF8 antibodies or antigen binding protein or fragment thereof which may inhibit GDF8 activity and signal in vitro and/or in vivo. The disclosure also provides for an immunoassay used to detect and quantitate GDF8. The disclosure also provides methods for diagnosing, preventing, ameliorating, and treating GDF8 associated disorders, e.g., degenerative orders of muscle, bone, and insulin metabolism. Finally, the disclosure provides pharmaceuticals for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
Abstract translation: 本公开提供了与生长和分化因子8（GDF8）相关的新分子，特别是GDF8特异性表位和GDF8的其他特异性拮抗剂，特别是可以抑制GDF8活性和体外信号的抗GDF8抗体或其抗原结合蛋白或其片段， /或体内。 本公开还提供用于检测和定量GDF8的免疫测定。 本公开还提供了用于诊断，预防，改善和治疗GDF8相关疾病例如肌肉，骨骼和胰岛素代谢的退行性顺序的方法。 最后，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种疾病的药物。
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公开(公告)号：US20140023638A1
公开(公告)日：2014-01-23
申请号：US13791700
申请日：2013-03-08
Applicant: Pfizer Inc.
Inventor： Edward Roland LaVallie , Lisa Anne Collins-Racie , Christopher John Corcoran , Lioudmila Gennadievna Tchistiakova , John Adam Nowak , Riyez Karim , Xiang-Yang Tan , Kimberly Ann Marquette , Geertruida Machteld Veldman
IPC: C07K16/22
CPC classification number: C07K16/22 , A61K39/395 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: The disclosure provides novel molecules related to growth and differentiation factor 8 (GDF8), in particular epitopes specific to GDF8 and other specific antagonists of GDF8 in particular anti GDF8 antibodies or antigen binding protein or fragment thereof which may inhibit GDF8 activity and signal in vitro and/or in vivo. The disclosure also provides for an immunoassay used to detect and quantitate GDF8. The disclosure also provides methods for diagnosing, preventing, ameliorating, and treating GDF8 associated disorders, e.g., degenerative orders of muscle, bone, and insulin metabolism. Finally, the disclosure provides pharmaceuticals for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
Abstract translation: 本公开提供了与生长和分化因子8（GDF8）相关的新分子，特别是GDF8特异性表位和GDF8的其他特异性拮抗剂，特别是可以抑制GDF8活性和体外信号的抗GDF8抗体或其抗原结合蛋白或其片段， /或体内。 本公开还提供用于检测和定量GDF8的免疫测定。 本公开还提供了用于诊断，预防，改善和治疗GDF8相关疾病例如肌肉，骨骼和胰岛素代谢的退行性顺序的方法。 最后，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种疾病的药物。
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