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    INTESTINAL HYPERPERMEABILITY AND PREVENTION OF SYSTEMIC DISEASE
    2.
    发明申请
    INTESTINAL HYPERPERMEABILITY AND PREVENTION OF SYSTEMIC DISEASE 审中-公开

    公开(公告)号：US20140213534A1

    公开(公告)日：2014-07-31

    申请号：US14122170

    申请日：2012-04-27

    申请人： Scott A. Waldman ,  Adam E. Snook ,  Peng Li ,  Jieru Egeria Lin

    发明人： Scott A. Waldman ,  Adam E. Snook ,  Peng Li ,  Jieru Egeria Lin

    IPC分类号： A61K38/10 ,  A61K45/06

    CPC分类号： A61K38/10 ,  A61K38/005 ,  A61K45/06

    摘要： Compositions for and methods of preventing or reducing the severity intestinal hyperpermeabilization in an individual are disclosed. Compositions for and methods of preventing or reducing the severity of a disease or condition caused or exacerbated by intestinal hyperpermeabilization in an individual identified as being at risk of a disease or condition caused or exacerbated by intestinal hyperpermeabilization are also disclosed. Compositions for and methods of treating an individual who has been identified as having a disease or condition caused or exacerbated by intestinal hyperpermeabilization are additionally disclosed.

    摘要翻译： 公开了预防或减轻个体严重性肠过度超敏化的组合物和方法。 还公开了预防或降低由被鉴定为处于由肠过度超化引起或加剧的疾病或病症的风险中的个体肠道过度超敏引起或加重的疾病或病症的严重性的组合物和方法。 另外还公开了已被鉴定为具有由肠过度超化引起或加剧的疾病或病症的个体的组合物和方法。

    COMPOSITIONS FOR AND METHODS OF ACTIVATING GUANYLYL CYCLASE C
    3.
    发明申请
    COMPOSITIONS FOR AND METHODS OF ACTIVATING GUANYLYL CYCLASE C 审中-公开
    组合物和活化方法C

    公开(公告)号：US20120225099A1

    公开(公告)日：2012-09-06

    申请号：US13378658

    申请日：2010-02-24

    申请人： Scott A. Waldman ,  Giovanni Pitari ,  Tong Li

    发明人： Scott A. Waldman ,  Giovanni Pitari ,  Tong Li

    IPC分类号： A61K38/02 ,  A61K9/00 ,  A61P1/00 ,  A61K38/16 ,  A61P35/00 ,  C12N1/21 ,  A61K38/10

    CPC分类号： A61K35/74 ,  A61K35/741 ,  Y02A50/471 ,  Y02A50/473

    摘要： Isolated non-pathogenic bacterium which comprises a nucleic acid molecule that encodes guanylyl cyclase C agonist operably linked to regulatory sequences operable in bacterium and isolated bacterium which comprises a nucleic acid molecule that encodes guanylyl cyclase C agonist operably linked to inducible regulatory sequences operable in bacterium are disclosed. Isolated culture of such bacteria and uses thereof in the prevention and treatment of colonic polyps and/or colorectal cancer as well as methods of activating guanylyl cyclase C in humans are disclosed.

    摘要翻译： 分离的非致病细菌，其包含编码可以在细菌和分离的细菌中可操作的调节序列可操作地连接的调控序列的鸟苷酸环化酶C激动剂的核酸分子，其包含编码与可在细菌中可操作的可诱导调节序列可操作地连接的鸟苷酸环化酶C激动剂的核酸分子 披露 公开了这种细菌的分离培养物及其在预防和治疗结肠息肉和/或结肠直肠癌中的用途以及在人中激活鸟苷酸环化酶C的方法。

    Cancer Vaccines Against Mucosal Antigens and Methods of Making and Using the Same
    4.
    发明申请
    Cancer Vaccines Against Mucosal Antigens and Methods of Making and Using the Same 审中-公开
    癌症疫苗对粘膜抗原的制备和使用方法

    公开(公告)号：US20110206736A1

    公开(公告)日：2011-08-25

    申请号：US13120144

    申请日：2009-09-22

    申请人： Scott A. Waldman ,  Adam E. Snook

    发明人： Scott A. Waldman ,  Adam E. Snook

    IPC分类号： A61K39/00 ,  C07H21/04 ,  C12N7/00 ,  C07K14/00 ,  C12N9/96 ,  A61P35/00

    CPC分类号： A61K39/0011 ,  A61K2039/57

    摘要： Nucleic acid molecules comprising a nucleotide sequence that encodes a chimeric protein are disclosed. The chimeric proteins comprise at least one epitope of a mucosally restricted antigen, at least one CD4+ helper epitope, and, optionally, a secretion sequence. Chimeric proteins that comprise at least one epitope of a mucosally restricted antigen, at least one CD4+helper epitope and, optionally a secretion sequence are also disclosed. Compositions including pharmaceutical compositions and injectables comprising nucleic acid molecule and proteins are disclosed. Methods of treating individuals diagnosed with cancer of a mucosal tissue and methods of preventing cancer of a mucosal tissue are disclosed.

    摘要翻译： 公开了包含编码嵌合蛋白质的核苷酸序列的核酸分子。 嵌合蛋白质包含粘膜受限抗原，至少一种CD4 +辅助表位和任选的分泌序列的至少一个表位。 还公开了包含粘膜受限抗原的至少一个表位，至少一种CD4 +辅助表位和任选的分泌序列的嵌合蛋白。 公开了包含药物组合物和包含核酸分子和蛋白质的注射剂的组合物。 公开了治疗患有粘膜组织癌症的个体的方法和预防粘膜组织癌症的方法。

    METASTATIC COLORECTAL CANCER VACCINE
    5.
    发明申请
    METASTATIC COLORECTAL CANCER VACCINE 有权
    分子性阴道癌疫苗

    公开(公告)号：US20100196408A1

    公开(公告)日：2010-08-05

    申请号：US12564887

    申请日：2009-09-22

    申请人： Scott A. Waldman

    发明人： Scott A. Waldman

    IPC分类号： A61K39/00 ,  A61K39/12 ,  C07K14/00 ,  A61K39/23

    CPC分类号： C07K14/705 ,  A61K39/00

    摘要： The invention relates to prophylactic and therapeutic vaccines for protecting individuals against metastatic colorectal cancer and for treating individuals who are suffering from metastatic colorectal cancer.

    摘要翻译： 本发明涉及用于保护个体免受转移性结肠直肠癌和用于治疗患有转移性结肠直肠癌的个体的预防和治疗性疫苗。

    ST receptor binding compounds and methods of using the same
    6.
    发明授权
    ST receptor binding compounds and methods of using the same 有权
    ST受体结合化合物及其使用方法

    公开(公告)号：US07744870B1

    公开(公告)日：2010-06-29

    申请号：US09724983

    申请日：2000-11-28

    申请人： Scott A. Waldman

    发明人： Scott A. Waldman

    IPC分类号： A61K39/395 ,  A61K35/12

    CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K47/6425 ,  A61K51/08 ,  A61K2121/00 ,  C07K14/24 ,  Y02A50/473

    摘要： Conjugated compounds which comprises an ST receptor binding moiety and a radiostable active moiety are disclosed. Pharmaceutical compositions comprising a pharmaceutically acceptable carrier or diluent, and a conjugated compound which comprises an ST receptor binding moiety and a radiostable active moiety or an ST receptor binding moiety and a radioactive, active moiety are disclosed. Methods of treating an individual suspected of suffering from metastasized colorectal cancer comprising the steps of administering to said individual a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent, and a therapeutically effective amount of a conjugated compound which comprises an ST receptor binding moiety and a radiostable active moiety or an ST receptor binding moiety and a radiostable active moiety are disclosed. Methods of radioimaging metastasized colorectal cancer cells comprising the steps of first administering to an individual suspected of having metastasized colorectal cancer cells, a pharmaceutical composition that comprises a pharmaceutically acceptable carrier or diluent, and conjugated compound that comprises an ST receptor binding moiety and a radioactive active moiety wherein the conjugated compound is present in an amount effective for diagnostic use in humans suffering from colorectal cancer and then detecting the localization and accumulation of radioactivity in the individual's body are disclosed.

    摘要翻译： 公开了包含ST受体结合部分和无定型活性部分的共轭化合物。 公开了包含药学上可接受的载体或稀释剂的药物组合物和包含ST受体结合部分和不稳定活性部分或ST受体结合部分和放射性活性部分的共轭化合物。 治疗疑似患有转移性结肠直肠癌的个体的方法包括以下步骤：向所述个体施用包含药学上可接受的载体或稀释剂的药物组合物和治疗有效量的包含ST受体结合部分和不稳定的结合化合物 公开了活性部分或ST受体结合部分和无定型活性部分。 包括以下步骤的放射性成像转移性结肠直肠癌细胞的方法：首先给予疑似患有转移性结肠直肠癌细胞的个体，包含药学上可接受的载体或稀释剂的药物组合物和包含ST受体结合部分和放射性活性物质的缀合化合物 公开了其中偶联化合物以有效用于患有结肠直肠癌的人的诊断用量的量存在，然后检测个体身体中放射性的定位和积累的部分。

    Imaging of colorectal cancer using ST receptor binding compounds
    8.
    发明授权
    Imaging of colorectal cancer using ST receptor binding compounds 有权
    使用ST受体结合化合物成像结肠直肠癌

    公开(公告)号：US06268159B1

    公开(公告)日：2001-07-31

    申请号：US09138237

    申请日：1998-08-21

    申请人： Scott A. Waldman

    发明人： Scott A. Waldman

    IPC分类号： G01N33574

    CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K47/6425 ,  A61K51/08 ,  A61K2121/00 ,  C07K14/24 ,  Y02A50/473

    摘要： Conjugated compounds which comprises an ST receptor binding moiety and a radiostable active moiety are disclosed. Pharmaceutical compositions comprising a pharmaceutically acceptable carrier or diluent, and a conjugated compound which comprises an ST receptor binding moiety and a radiostable active moiety or an ST receptor binding moiety and a radioactive active moiety are disclosed. Methods of treating an individual suspected of suffering from metastasized colorectal cancer comprising the steps of administering to said individual a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent, and a therapeutically effective amount of a conjugated compound which comprises an ST receptor binding moiety and a radiostable active moiety or an ST receptor binding moiety and a radiostable active moiety are disclosed. Methods of radioimaging metastasized colorectal cancer cells comprising the steps of first administering to an individual suspected of having metastasized colorectal cancer cells, a pharmaceutical composition that comprises a pharmaceutically acceptable carrier or diluent, and conjugated compound that comprises an ST receptor binding moiety and a radioactive active moiety wherein the conjugated compound is present in an amount effective for diagnostic use in humans suffering from colorectal cancer and then detecting the localization and accumulation of radioactivity in the individual's body are disclosed.

    摘要翻译： 公开了包含ST受体结合部分和无定型活性部分的共轭化合物。 公开了包含药学上可接受的载体或稀释剂的药物组合物和包含ST受体结合部分和不稳定活性部分或ST受体结合部分和放射性活性部分的共轭化合物。 治疗疑似患有转移性结肠直肠癌的个体的方法包括以下步骤：向所述个体施用包含药学上可接受的载体或稀释剂的药物组合物和治疗有效量的包含ST受体结合部分和不稳定的结合化合物 公开了活性部分或ST受体结合部分和无定型活性部分。 包括以下步骤的放射性成像转移性结肠直肠癌细胞的方法：首先给予疑似患有转移性结肠直肠癌细胞的个体，包含药学上可接受的载体或稀释剂的药物组合物和包含ST受体结合部分和放射性活性物质的缀合化合物 公开了其中偶联化合物以有效用于患有结肠直肠癌的人的诊断用量的量存在，然后检测个体身体中放射性的定位和积累的部分。

    USE OF GCC LIGANDS
    9.
    发明申请
    USE OF GCC LIGANDS 审中-公开
    海湾合作委员会使用权

    公开(公告)号：US20120308583A1

    公开(公告)日：2012-12-06

    申请号：US13526771

    申请日：2012-06-19

    申请人： Scott A. Waldman ,  Giovanni Mario Pitari ,  Jason Park ,  Stephanie Schulz ,  Henry Wolfe ,  Wilhelm Lubbe

    发明人： Scott A. Waldman ,  Giovanni Mario Pitari ,  Jason Park ,  Stephanie Schulz ,  Henry Wolfe ,  Wilhelm Lubbe

    IPC分类号： A61K38/02 ,  A61P35/00 ,  A61K39/395

    CPC分类号： G01N33/57419 ,  A61K38/00 ,  A61K38/177 ,  A61K47/6415 ,  A61K51/088 ,  G01N33/57446

    摘要： Proliferation of colorectal, gastric and esophageal cancer cells is inhibited by administering ST receptor ligand. The number of ST receptor molecules on the surface of a colorectal cell or metastasized colorectal cancer cell are increased by administering an ST receptor ligand such that ligand comes into contact with an ST receptor on the surface of the colorectal cell. Pharmaceutical compositions comprise sterile, pyrogen free ST receptor ligand and a pharmaceutically acceptable carrier or diluent. Metastasized colorectal cancer is treated or imaged by increasing the number of ST receptor molecules on the surface of a metastasized colorectal cancer cell and then administering a pharmaceutical composition containing components that target the ST receptor for delivery of a therapeutic agent or imaging agent. Methods of detecting metastasized colorectal cancer are disclosed. Methods of delivering active compounds to a colorectal cell in an individual are disclosed.

    摘要翻译： 通过施用ST受体配体抑制结肠直肠癌，胃癌和食管癌细胞的增殖。 通过施用ST受体配体使得配体与结肠直肠细胞表面上的ST受体接触，增加了结肠直肠细胞或转移性结肠直肠癌细胞表面上ST受体分子的数量。 药物组合物包含无菌，无热原性ST受体配体和药学上可接受的载体或稀释剂。 通过增加转移性结肠直肠癌细胞表面上的ST受体分子的数量来治疗或成像转移性结肠直肠癌，然后施用含有靶向ST受体的成分以用于递送治疗剂或成像剂的药物组合物。 公开了检测转移性结肠直肠癌的方法。 公开了将活性化合物递送至个体的结肠直肠细胞的方法。