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公开(公告)号：US20060223077A1
公开(公告)日：2006-10-05
申请号：US11229770
申请日：2005-09-20
Applicant: Jian Ni , Reinhard Ebner , David LaFleur , Paul Moore , Henrik Olsen , Craig Rosen , Steven Ruben , Daniel Soppet , Paul Young , Yanggu Shi , Kimberly Florence , Ying-Fei Wei , Charles Florence , Jing-Shan Hu , Yi Li , Hla Kyaw , Carrie Fischer , Ann Ferrie , Ping Fan , Ping Feng , Gregory Endress , Patrick Dillon , Kenneth Carter , Laurie Brewer , Guo-Liang Yu , Zhizhen Zeng , John Greene
Inventor： Jian Ni , Reinhard Ebner , David LaFleur , Paul Moore , Henrik Olsen , Craig Rosen , Steven Ruben , Daniel Soppet , Paul Young , Yanggu Shi , Kimberly Florence , Ying-Fei Wei , Charles Florence , Jing-Shan Hu , Yi Li , Hla Kyaw , Carrie Fischer , Ann Ferrie , Ping Fan , Ping Feng , Gregory Endress , Patrick Dillon , Kenneth Carter , Laurie Brewer , Guo-Liang Yu , Zhizhen Zeng , John Greene
Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
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公开(公告)号：US20060073573A1
公开(公告)日：2006-04-06
申请号：US11244394
申请日：2005-10-06
Applicant: Jian Ni , Reiner Gentz , Guo-Liang Yu , Jeffrey Su , Patrick Dillon
Inventor： Jian Ni , Reiner Gentz , Guo-Liang Yu , Jeffrey Su , Patrick Dillon
CPC classification number: C07K14/52 , A61K38/00 , C07K14/521 , Y02A50/423
Abstract: Human chemotactic cytokine III polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever, cerebral ischemia, glomerulonephritis, HTLV-1 related diseases and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding chemotactic cytokine III and for detecting altered levels of the polypeptide in a host.
Abstract translation: 公开了人类趋化性细胞因子III多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 针对这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫和慢性和急性炎症和感染性疾病，过敏反应，前列腺素不依赖性发烧，脑缺血，肾小球肾炎，HTLV-1相关疾病和骨髓衰竭的治疗用途 也被披露。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子III的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。
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公开(公告)号：US20050037966A1
公开(公告)日：2005-02-17
申请号：US10901210
申请日：2004-07-29
Applicant: Steven Ruben , Pablo Jimenez , Roxanne Duan , Mark Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul Moore , Timothy Coleman , Joachim Gruber , Patrick Dillon , Reiner Gentz
Inventor： Steven Ruben , Pablo Jimenez , Roxanne Duan , Mark Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul Moore , Timothy Coleman , Joachim Gruber , Patrick Dillon , Reiner Gentz
CPC classification number: C07K14/50 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00
Abstract: This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
Abstract translation: 本发明涉及新鉴定的多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这种多核苷酸和多肽的产生。 更具体地，本发明的多肽是角质形成细胞生长因子，有时在下文中称为“KGF-2”，以前称为成纤维细胞生长因子12（FGF-12）。 本发明还涉及KGF-2促进或加速伤口愈合的治疗用途。 本发明还涉及显示增强的活性，增加的稳定性，更高的产量或更好的溶解度的KGF-2的新型突变形式。
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公开(公告)号：US20050009141A1
公开(公告)日：2005-01-13
申请号：US10915596
申请日：2004-08-11
Applicant: Jian Ni , Ping Feng , Patrick Dillon , Reiner Gentz , Joseph Merregaert , Patrick Smits
Inventor： Jian Ni , Ping Feng , Patrick Dillon , Reiner Gentz , Joseph Merregaert , Patrick Smits
IPC: G01N33/50 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P43/00 , C07K14/47 , C07K14/485 , C07K16/22 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12R1/91 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/577 , C07K14/705 , C07H21/04 , C07K16/28
CPC classification number: C07K14/47 , A61K38/00 , A61K48/00 , C12N2799/026
Abstract: A human epidermal differentiation factor polypeptide and DNA (RNA) encoding such polypeptide and procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating and/or preventing skin diseases. Diagnostic assays for detecting mutations in a nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
Abstract translation: 公开了通过重组技术产生这种多肽的人表皮分化因子多肽和编码这种多肽的DNA（RNA）和方法。 还公开了利用这种多肽治疗和/或预防皮肤疾病的方法。 还公开了用于检测编码本发明多肽的核酸序列中的突变并用于检测本发明多肽的改变水平的诊断测定。
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公开(公告)号：US20070259806A1
公开(公告)日：2007-11-08
申请号：US11757481
申请日：2007-06-04
Applicant: Gregg Hastings , Timothy Coleman , Patrick Dillon , Daniel Lawrence , Maria Sandkvist , Manuel Yepes , Michael Wong
Inventor： Gregg Hastings , Timothy Coleman , Patrick Dillon , Daniel Lawrence , Maria Sandkvist , Manuel Yepes , Michael Wong
IPC: A61K38/00 , C07H21/04 , C07K14/00 , C07K16/18 , C12N15/00 , C12N15/87 , C12N5/06 , C12P1/04 , G01N33/53
CPC classification number: C07K16/40 , A61K2039/505 , C07K14/8132 , G01N33/6896 , G01N33/86 , G01N2800/2821 , G01N2800/285 , G01N2800/2857 , G01N2800/2871
Abstract: The present invention relates to a novel BAIT protein which is a member of serpin superfamily which is expressed primarily in brain tissue. In particular, isolated nucleic acid molecules are provided encoding the human and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of BAIT activity. Also provided are diagnostic methods for detecting nervous system-related disorders and therapeutic methods for treating nervous system-related disorders. Additionally, the present invention is related to methods of treating patients with BAIT polynucleotides or polypeptides, wherein said patients have had seizures or epilepsy.
Abstract translation: 本发明涉及一种新的BAIT蛋白，其是主要在脑组织中表达的丝氨酸蛋白酶超家族的成员。 特别地，提供了分离的核酸分子，其编码人和其制备方法。 本发明还涉及鉴定BAIT活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测神经系统相关疾病的诊断方法和用于治疗神经系统相关疾病的治疗方法。 另外，本发明涉及治疗患有BAIT多核苷酸或多肽的患者的方法，其中所述患者具有癫痫发作或癫痫。
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Patent Agency Ranking
公开(公告)号：US20070020746A1
公开(公告)日：2007-01-25
申请号：US10807556
申请日：2004-03-24
Applicant: Charles Kunsch , Gil Choi , Steven Barash , Patrick Dillon , Michael Fannon , Craig Rosen
Inventor： Charles Kunsch , Gil Choi , Steven Barash , Patrick Dillon , Michael Fannon , Craig Rosen
CPC classification number: C12N15/1093 , A61K39/00 , C07K14/31 , C12N15/52
Abstract: The present invention provides polynucleotide sequences of the genome of Staphylococcus aureus, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.
Abstract translation: 本发明提供金黄色葡萄球菌基因组的多核苷酸序列，由多核苷酸序列编码的多肽序列，相应的多核苷酸和多肽，载体和包含多核苷酸的宿主，以及其测定和其它用途。 本发明还提供了存储在计算机可读介质上的多核苷酸和多肽序列信息，以及便于其使用的基于计算机的系统和方法。
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公开(公告)号：US20060063922A1
公开(公告)日：2006-03-23
申请号：US11268629
申请日：2005-11-08
Applicant: Jian Ni , Ping Feng , Patrick Dillon , Reiner Gentz , Joseph Merregaert , Patrick Smits
Inventor： Jian Ni , Ping Feng , Patrick Dillon , Reiner Gentz , Joseph Merregaert , Patrick Smits
IPC: C07H21/04 , C07K14/475 , A61K38/18 , C12P21/06
CPC classification number: C07K14/47 , A61K38/00 , A61K48/00 , C12N2799/026
Abstract: A human epidermal differentiation factor polypeptide and DNA (RNA) encoding such polypeptide and procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating and/or preventing skin diseases. Diagnostic assays for detecting mutations in a nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
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公开(公告)号：US20050227282A1
公开(公告)日：2005-10-13
申请号：US11142735
申请日：2005-06-02
Applicant: Jian Ni , Ping Feng , Patrick Dillon , Reiner Gentz , Joseph Merregaert , Patrick Smits
Inventor： Jian Ni , Ping Feng , Patrick Dillon , Reiner Gentz , Joseph Merregaert , Patrick Smits
IPC: G01N33/50 , A61K38/00 , A61K45/00 , A61K48/00 , A61P9/00 , A61P19/10 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/47 , C07K14/51 , C07K14/785 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/15
CPC classification number: C12Q1/6883 , A61K38/00 , A61K48/00 , A61K2039/51 , C07K14/47 , C07K14/51 , C12N2799/026 , C12Q2600/156 , Y10T436/143333
Abstract: A human ECM-1 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating the differentiation in growth of osteoblasts and osteoclasts, which may be used to promote the healing of bone fractures and de novo bone formation, for osteoporosis, for and to promote angiogenesis. Antagonists to the polypeptide of the present invention are also disclosed which may be utilized to treat osteodystrophy, osteohypertrophy, osteoma, osteoblastoma and cancers. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention.
Abstract translation: 公开了编码这种多肽的人ECM-1多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽刺激成骨细胞和破骨细胞生长分化的方法，其可用于促进骨折愈合和从头骨形成，用于骨质疏松症，促进血管生成。 还公开了本发明多肽的拮抗剂，其可用于治疗骨营养不良，骨质肥大，骨瘤，成骨细胞瘤和癌症。 用于鉴定编码本发明多肽的核酸序列中的突变的诊断测定。
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公开(公告)号：US20050181439A1
公开(公告)日：2005-08-18
申请号：US11106649
申请日：2005-04-15
Applicant: Gil Choi , Charles Kunsch , Steven Barash , Patrick Dillon , Brian Dougherty , Michael Fannon , Craig Rosen
Inventor： Gil Choi , Charles Kunsch , Steven Barash , Patrick Dillon , Brian Dougherty , Michael Fannon , Craig Rosen
IPC: G01N33/53 , A01K67/027 , A61K38/00 , A61K39/00 , A61K39/09 , A61K48/00 , A61P31/04 , C07K14/315 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/10 , C12N5/18 , C12N15/09 , C12N15/31 , C12P21/02 , C12Q1/68 , G01N33/50 , G01N33/569 , G06F17/30 , C07H21/04 , C07K14/31 , C12N15/74
CPC classification number: C07K14/3156 , A61K38/00 , A61K39/00 , C07K14/315
Abstract: The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.
Abstract translation: 本发明涉及用于预防或减轻肺炎链球菌感染的新型疫苗。 本发明还涉及编码肺炎链球菌抗原多肽的分离的核酸分子。 还提供了抗原多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及在生物样品中检测链球菌核酸，多肽和抗体的诊断方法。
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公开(公告)号：US6024294A
公开(公告)日：2000-02-15
申请号：US89970
申请日：1998-06-03
Applicant: Patrick Dillon
Inventor： Patrick Dillon
CPC classification number: A01C15/02 , A23G3/2076 , A23P20/12
Abstract: A portable spreader of small particulate materials comprising a container having a wide mouth neck. The container holds the small particulate materials therein. A cap has a top opening. The cap engages with the wide mouth neck of the container. An electronic device is built onto the cap over the top opening, for distributing the small particulate materials away from the container, when the container held in a hand of a person is inverted.
Abstract translation: 一种小型颗粒材料的便携式吊具，其包括具有宽口颈的容器。 容器中容纳小颗粒物质。 帽子有一个顶部的开口。 盖子与容器的宽口颈部接合。 将电子装置安装在顶部开口上的盖子上，以便当将握住人的手中的容器倒转时，将小颗粒材料远离容器分配。
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