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公开(公告)号：US20220072497A1
公开(公告)日：2022-03-10
申请号：US17455313
申请日：2021-11-17
摘要： The invention relates to an apparatus for producing a droplet assembly, which apparatus comprises a droplet generator. A process for producing a droplet assembly, using an apparatus comprising a droplet generator is also described. The invention also relates to droplet assemblies comprising a plurality of droplets. Various uses of the droplet assemblies are also described.
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公开(公告)号：US10978218B2
公开(公告)日：2021-04-13
申请号：US15788441
申请日：2017-10-19
IPC分类号： H01B7/00 , C12M1/34 , G01N27/416 , G01N33/68 , H01H1/00 , H01H1/021 , H01L51/00 , C08J3/075 , C12M1/12 , B32B9/00 , B32B17/06 , H01B1/06 , H01B3/00 , H05K1/03
摘要： The invention provides a hydrogel network comprising a plurality of hydrogel objects, wherein each of said hydrogel objects comprises: a hydrogel body, and an outer layer of amphipathic molecules, on at least part of the surface of the hydrogel body, wherein each of said hydrogel objects contacts another of said hydrogel objects to form an interface between the contacting hydrogel objects. A process for producing the hydrogel networks is also provided. The invention also provides an electrochemical circuit and a hydrogel component for mechanical devices comprising a hydrogel network. Various uses of the hydrogel network are also described, including their use in synthetic biology and as components in electrochemical circuits and mechanical devices.
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公开(公告)号：US12073966B2
公开(公告)日：2024-08-27
申请号：US17165252
申请日：2021-02-02
发明人： John Hagan Pryce Bayley , Kunwar Tanuj Sapra , Tobias Wauer , Holger Gerlach , Shiksha Mantri , Jamie Hill
CPC分类号： H01F1/445 , B01L3/502792 , B01L2200/0673 , B01L2400/043 , Y10T137/0391
摘要： The invention relates to a process for moving a droplet from a first location to a second location, which droplet comprises a magnetic material disposed in an aqueous medium. The invention also relates to a droplet assembly comprising a droplet, which droplet comprises a magnetic material disposed in an aqueous medium. Various uses of the droplet assembly are also described.
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公开(公告)号：US11998642B2
公开(公告)日：2024-06-04
申请号：US17853000
申请日：2022-06-29
IPC分类号： A61K9/50 , A61K9/113 , A61K31/085 , A61K49/00 , B01J13/02 , C09B67/02 , A61K9/107 , A61K9/127
CPC分类号： A61K9/50 , A61K9/113 , A61K31/085 , A61K49/0002 , B01J13/02 , B01J13/025 , C09B67/0097 , A61K9/1075 , A61K9/1271 , Y10T428/2984
摘要： The invention provides a droplet encapsulate comprising: a drop of a hydrophobic medium; a peripheral layer of non-polymeric amphipathic molecules around the surface of the drop; and an aqueous droplet within the peripheral layer, the aqueous droplet comprising: (a) an aqueous medium and (b) an outer layer of non-polymeric amphipathic molecules around the surface of the aqueous medium. The invention also provides processes for preparing the droplet encapsulates. Various uses of the droplet encapsulates are also described, including their use as drug delivery vehicles, in synthetic biology, and in the study of membrane proteins.
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公开(公告)号：US20170233803A1
公开(公告)日：2017-08-17
申请号：US15491505
申请日：2017-04-19
IPC分类号： C12Q1/68 , G01N33/487
摘要： The invention relates to a method for sequencing a heteropolymeric target nucleic acid sequence that involves stochastic sensing. The invention also relates to a method for improving a pore for sequencing a target nucleic acid sequence by modifying one or more sites in the pore.
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公开(公告)号：US11624047B2
公开(公告)日：2023-04-11
申请号：US16305655
申请日：2017-06-02
IPC分类号： C12M3/00 , B81C99/00 , C12M1/12 , C12N11/04 , C12N11/087 , C12N11/084
摘要： The invention provides a process for producing a gel network, which gel network comprises a plurality of joined gel objects, which process comprises: forming a plurality of gel objects in one or more microfluidic channels; dispensing the gel objects from the one or more microfluidic channels into a region for producing the network; and contacting each gel object with at least one other gel object in said region to join each gel object to at least one other gel object at a region of contact between the gel objects. The invention also provides a network of joined gel objects, comprising a plurality of gel objects, wherein each gel object is joined to an adjacent gel object at a region of contact between the gel objects. Also provided are various possible uses of the gel network.
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公开(公告)号：US10712254B2
公开(公告)日：2020-07-14
申请号：US15023652
申请日：2014-09-22
IPC分类号： G01N15/10 , A61K38/00 , G01N33/68 , G01N33/487
摘要： The invention relates to a new method of determining the presence, absence, number or position(s) of one or more post-translational modifications in a peptide, polypeptide or protein. The invention uses transmembrane pores.
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公开(公告)号：US10548852B2
公开(公告)日：2020-02-04
申请号：US14354706
申请日：2012-11-02
IPC分类号： A61K9/50 , B01J13/02 , A61K31/085 , A61K49/00
摘要： The invention provides a droplet encapsulate comprising: a drop of a hydrophobic medium; a peripheral layer of non-polymeric amphipathic molecules around the surface of the drop; and an aqueous droplet within the peripheral layer, the aqueous droplet comprising: (a) an aqueous medium and (b) an outer layer of non-polymeric amphipathic molecules around the surface of the aqueous medium. The invention also provides processes for preparing the droplet encapsulates. Various uses of the droplet encapsulates are also described, including their use as drug delivery vehicles, in synthetic biology, and in the study of membrane proteins.
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公开(公告)号：US20180096751A1
公开(公告)日：2018-04-05
申请号：US15788441
申请日：2017-10-19
IPC分类号： H01B7/00 , C12M1/12 , B32B9/00 , H05K1/03 , B32B17/06 , C12M1/34 , G01N27/416 , G01N33/68 , H01H1/00 , H01H1/021 , H01L51/00 , H01B1/06 , H01B3/00 , C08J3/075
CPC分类号： H01B7/0027 , B32B9/00 , B32B17/06 , B32B2457/00 , C08J3/075 , C08J2305/12 , C12M1/34 , C12M1/3407 , C12M25/14 , G01N27/416 , G01N33/6872 , H01B1/06 , H01B3/00 , H01H1/0036 , H01H1/021 , H01L51/00 , H05K1/0306 , H05K1/0326 , H05K2201/0162 , Y10T156/10 , Y10T428/26 , Y10T428/31971
摘要： The invention provides a hydrogel network comprising a plurality of hydrogel objects, wherein each of said hydrogel objects comprises: a hydrogel body, and an outer layer of amphipathic molecules, on at least part of the surface of the hydrogel body, wherein each of said hydrogel objects contacts another of said hydrogel objects to form an interface between the contacting hydrogel objects. A process for producing the hydrogel networks is also provided. The invention also provides an electrochemical circuit and a hydrogel component for mechanical devices comprising a hydrogel network. Various uses of the hydrogel network are also described, including their use in synthetic biology and as components in electrochemical circuits and mechanical devices.
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公开(公告)号：US20230193181A1
公开(公告)日：2023-06-22
申请号：US17999286
申请日：2021-05-20
摘要： The invention relates to an apparatus for producing a droplet assembly, which apparatus comprises: at least one droplet generator suitable for generating droplets of a viscous droplet medium; a droplet receiving region which is moveable relative to the at least one droplet generator; a temperature controller; and a control unit, which control unit is adapted to control the dispensing of droplets from the at least one droplet generator and the movement of the droplet receiving region relative to the at least one droplet generator, wherein the apparatus is adapted to produce a droplet assembly in the droplet receiving region, wherein the droplet assembly comprises a plurality of droplets, wherein each of said droplets comprises (i) a droplet medium, and (ii) an outer layer of amphipathic molecules around the surface of the droplet medium.
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