公开(公告)号：US11766482B2

公开(公告)日：2023-09-26

申请号：US17381775

申请日：2021-07-21

Applicant: Ossianix, Inc.

Inventor： Pawel Stocki ,  Krzysztof Bartlomiej Wicher ,  Julia Lynn Rutkowski ,  Fabrizio Comper ,  Mykhaylo Demydchuk ,  Jaroslaw Michal Szary

IPC: A61K39/00 ,  A61K47/64 ,  G01N33/68 ,  C07K16/28 ,  C07K16/40 ,  C12N15/10 ,  C12N15/09 ,  G01N33/58 ,  A61K47/56 ,  C12N15/113 ,  C40B30/06 ,  C40B40/10

CPC classification number: A61K47/64 ,  A61K47/56 ,  C07K16/2881 ,  C07K16/2887 ,  C07K16/40 ,  C12N15/09 ,  C12N15/1037 ,  C12N15/113 ,  G01N33/58 ,  G01N33/68 ,  A61K2039/505 ,  C07K2317/20 ,  C07K2317/31 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/94 ,  C07K2319/30 ,  C12N2320/32 ,  C40B30/06 ,  C40B40/10

Abstract: The present invention relates to the fields of molecular medicine and targeted delivery of therapeutic or diagnostic agents to cells outside the vascular system and into the parenchymal tissue of organs within the body. More specifically, the present invention relates to the methods used to identify membrane receptors or transporters capable of carrying cargo specifically targeted to the parenchymal tissue of the brain and to in vivo enrichment methods for selecting peptides that are transported across the blood-brain barrier (“BBB”), or analogously, across other membrane containing organs or structures, such as liver, spleen, kidney and tumors.

公开(公告)号：US11097010B2

公开(公告)日：2021-08-24

申请号：US16323727

申请日：2017-08-04

Applicant: Ossianix, Inc.

Inventor： Pawel Stocki ,  Krzysztof Bartlomiej Wicher ,  Julia Lynn Rutkowski ,  Fabrizio Comper ,  Mykhaylo Demydchuk ,  Jaroslaw Michal Szary

IPC: A61K47/64 ,  G01N33/68 ,  C07K16/28 ,  C07K16/40 ,  C12N15/10 ,  C12N15/09 ,  G01N33/58 ,  A61K47/56 ,  C12N15/113 ,  A61K39/00 ,  C40B30/06 ,  C40B40/10

Abstract: The present invention relates to the fields of molecular medicine and targeted delivery of therapeutic or diagnostic agents to cells outside the vascular system and into the parenchymal tissue of organs within the body. More specifically, the present invention relates to the methods used to identify membrane receptors or transporters capable of carrying cargo specifically targeted to the parenchymal tissue of the brain and to in vivo enrichment methods for selecting peptides that are transported across the blood-brain barrier (“BBB”), or analogously, across other membrane containing organs or structures, such as liver, spleen, kidney and tumors.

公开(公告)号：US12187805B2

公开(公告)日：2025-01-07

申请号：US18033600

申请日：2021-11-09

Applicant: OSSIANIX, INC

Inventor： Pawel Stocki ,  Jaroslaw Michal Szary ,  Krzysztof Bartlomiej Wicher ,  Laura Thei ,  Julia Lynn Rutkowski ,  Mykhaylo Demydchuk ,  Shu-Fen Coker

IPC: C07K16/28 ,  A61P35/00 ,  C12N15/63 ,  G01N33/68

Abstract: The present invention relates to a high affinity, VNAR polypeptide cross reactive with primate transferrin receptors (“TfR”). This TfR-specific VNAR polypeptide was obtained by screening semisynthetic VNAR phage display libraries against recombinant human TfR-1. The VNAR polypeptides of the invention can be used alone or as a component in conjugates that target the transferrin/transferrin receptor transport system. The invention further includes use of this VNAR, its conjugates and other derivatives in diagnostic and therapeutic methods, e.g., to diagnose, treat and/or prevent a pathological condition, disorder or disease in which it is beneficial to deliver a heterologous biomolecule across the blood brain barrier or other membrane systems. This TfR-specific VNAR polypeptide can also be used to target other biological barriers such the intestines, the placenta or aberrant cells overexpressing TfR-1, for therapeutic benefit in treatment of certain cancer cells and tumors of various tissue types. Deimmunized VNAR scaffolds are also provided.