-
公开(公告)号：US20170101600A1
公开(公告)日：2017-04-13
申请号：US15382085
申请日：2016-12-16
CPC分类号： C07C403/24 , C07C2601/10 , C07C2601/16 , C11B3/001 , C11B3/006 , C11B3/008 , C11B3/10
摘要： Disclosed is a chromatographic process complex for the refining of krill oil extract including desalting, removal of impurities such as trimethylamine oxide (TMAO), and the production of krill oil products including desalted krill oil extract, polar lipid products having polar lipid contents greater than 50 wt-% on a dry or solvent free basis, neutral lipid streams for biodiesel production and astaxanthin. The refinery includes a continuous desalting zone, a fixed bed polar lipid extraction zone to adsorb neutral lipids and astaxanthin to provide a polar lipid extract stream comprising solvent and polar lipids and being essentially free of neutral lipids and astaxanthin, and an astaxanthin separation zone to recover essentially pure astaxanthin and provide a neutral lipid stream. The enriched products of the krill oil refinery are essentially free of TMAO and salt and provide products which can be used as dietary supplements and as medicinal additives.
-
公开(公告)号：US20170101373A1
公开(公告)日：2017-04-13
申请号：US15382555
申请日：2016-12-16
IPC分类号： C07C403/24
CPC分类号： C07C403/24 , C07C2601/10 , C07C2601/16 , C11B3/001 , C11B3/006 , C11B3/008 , C11B3/10
摘要： Disclosed is a chromatographic process complex for the refining of krill oil extract including desalting, removal of impurities such as trimethylamine oxide (TMAO), and the production of krill oil products including desalted krill oil extract, polar lipid products having polar lipid contents greater than 50 wt-% on a dry or solvent free basis, neutral lipid streams for biodiesel production and astaxanthin. The refinery includes a continuous desalting zone, a fixed bed polar lipid extraction zone to adsorb neutral lipids and astaxanthin to provide a polar lipid extract stream comprising solvent and polar lipids and being essentially free of neutral lipids and astaxanthin, and an astaxanthin separation zone to recover essentially pure astaxanthin and provide a neutral lipid stream. The enriched products of the krill oil refinery are essentially free of TMAO and salt and provide products which can be used as dietary supplements and as medicinal additives.
-
公开(公告)号：US09556116B2
公开(公告)日：2017-01-31
申请号：US14619102
申请日：2015-02-11
IPC分类号： C07C45/85 , C07C403/24 , C11B3/00 , C11B3/10
CPC分类号： C07C403/24 , C07C2601/10 , C07C2601/16 , C11B3/001 , C11B3/006 , C11B3/008 , C11B3/10
摘要： Disclosed is a chromatographic process complex for the refining of krill oil extract including desalting, removal of impurities such as trimethylamine oxide (TMAO), and the production of krill oil products including desalted krill oil extract, polar lipid products having polar lipid contents greater than 50 wt-% on a dry or solvent free basis, neutral lipid streams for biodiesel production and astaxanthin. The refinery includes a continuous desalting zone, a fixed bed polar lipid extraction zone to adsorb neutral lipids and astaxanthin to provide a polar lipid extract stream comprising solvent and polar lipids and being essentially free of neutral lipids and astaxanthin, and an astaxanthin separation zone to recover essentially pure astaxanthin and provide a neutral lipid stream. The enriched products of the krill oil refinery are essentially free of TMAO and salt and provide products which can be used as dietary supplements and as medicinal additives.
摘要翻译： 公开了一种用于精制磷虾油提取物的色谱法复合物，包括脱盐，去除杂质如三甲胺氧化物（TMAO），以及产生包括脱盐磷虾油提取物的磷虾油产品，极性脂质含量大于50 以干或无溶剂为基准，用于生物柴油生产的中性脂质流和虾青素。 炼油厂包括连续脱盐区，固定床极性脂质提取区，用于吸附中性脂质和虾青素，以提供极性脂质提取物流，其包含溶剂和极性脂质，并且基本上不含中性脂质和虾青素，以及虾青素分离区以回收 基本上是纯的虾青素并提供中性脂质流。 磷虾炼油厂的富集产品基本上不含TMAO和盐，并提供可用作膳食补充剂和药用添加剂的产品。
-
4.发明授权Method and apparatus for the extraction of vitamin D metabolites from human plasma 有权从人血浆中提取维生素D代谢物的方法和装置公开(公告)号：US09291535B2
公开(公告)日：2016-03-22
申请号：US14340641
申请日：2014-07-25
发明人： Asha A. Oroskar , Xuejun Zang , Javier Ramirez
CPC分类号： G01N1/4055 , B01J39/05 , B01J39/07 , B01L3/50255 , B01L2200/0631 , B01L2300/0681 , B01L2300/069 , B01L2300/0829 , B01L2400/0487 , B01L2400/049 , G01N1/4005 , G01N33/82 , G01N2001/4016 , G01N2001/4061
摘要： This invention relates to a method and apparatus or kit for extracting major metabolites of vitamin D from human plasma or serum. More particularly, the invention provides for the extraction from human plasma or serum samples comprising vitamin D metabolites such as 1,25-dihydroxy vitamin D3, 25-hydroxy vitamin D2, and D3 from protein binding, removal of protein and phospholipids, and isolation of the metabolites using a combination of ion-exchange and Lewis acid mechanisms without the requirement to acidify the samples. The method and apparatus of the invention comprise a cartridge or plurality of cartridges comprising at least one protein crash frit, a strong cation exchanged sorbent, and an acidified alumina sorbent to provide higher recoveries of vitamin D metabolites than existing phospholipid depletion plate techniques. Accurately quantifying 1,25-dihydroxy vitamin D3 is useful in differential diagnosis of vitamin D-related diseases and for monitoring vitamin D therapy in patients with chronic renal disease.
摘要翻译： 本发明涉及用于从人血浆或血清中提取维生素D的主要代谢物的方法和装置或试剂盒。 更具体地，本发明提供从蛋白质结合，去除蛋白质和磷脂中分离包含维生素D代谢物如1,25-二羟基维生素D3,25-羟基维生素D2和D3的人血浆或血清样品的提取，以及分离 代谢物使用离子交换和路易斯酸结合的组合，而不需要酸化样品。 本发明的方法和装置包括一个或多个盒，其包括至少一种蛋白质崩溃玻璃料，强阳离子交换的吸附剂和酸化的氧化铝吸附剂，以提供比现有的磷脂消耗板技术更高的维生素D代谢物回收率。 精确量化1,25-二羟维生素D3可用于维生素D相关疾病的鉴别诊断和用于监测慢性肾病患者的维生素D治疗。
-
公开(公告)号：US09650590B2
公开(公告)日：2017-05-16
申请号：US15382085
申请日：2016-12-16
IPC分类号： C07C403/24 , C11B3/10 , C11B3/00
CPC分类号： C07C403/24 , C07C2601/10 , C07C2601/16 , C11B3/001 , C11B3/006 , C11B3/008 , C11B3/10
摘要： Disclosed is a chromatographic process complex for the refining of krill oil extract including desalting, removal of impurities such as trimethylamine oxide (TMAO), and the production of krill oil products including desalted krill oil extract, polar lipid products having polar lipid contents greater than 50 wt-% on a dry or solvent free basis, neutral lipid streams for biodiesel production and astaxanthin. The refinery includes a continuous desalting zone, a fixed bed polar lipid extraction zone to adsorb neutral lipids and astaxanthin to provide a polar lipid extract stream comprising solvent and polar lipids and being essentially free of neutral lipids and astaxanthin, and an astaxanthin separation zone to recover essentially pure astaxanthin and provide a neutral lipid stream. The enriched products of the krill oil refinery are essentially free of TMAO and salt and provide products which can be used as dietary supplements and as medicinal additives.
-
公开(公告)号：US20160229781A1
公开(公告)日：2016-08-11
申请号：US14619102
申请日：2015-02-11
IPC分类号： C07C45/85
CPC分类号： C07C403/24 , C07C2601/10 , C07C2601/16 , C11B3/001 , C11B3/006 , C11B3/008 , C11B3/10
摘要： Disclosed is a chromatographic process complex for the refining of krill oil extract including desalting, removal of impurities such as trimethylamine oxide (TMAO), and the production of krill oil products including desalted krill oil extract, polar lipid products having polar lipid contents greater than 50 wt-% on a dry or solvent free basis, neutral lipid streams for biodiesel production and astaxanthin. The refinery includes a continuous desalting zone, a fixed bed polar lipid extraction zone to adsorb neutral lipids and astaxanthin to provide a polar lipid extract stream comprising solvent and polar lipids and being essentially free of neutral lipids and astaxanthin, and an astaxanthin separation zone to recover essentially pure astaxanthin and provide a neutral lipid stream. The enriched products of the krill oil refinery are essentially free of TMAO and salt and provide products which can be used as dietary supplements and as medicinal additives.
摘要翻译： 公开了一种用于精制磷虾油提取物的色谱法复合物，包括脱盐，去除杂质如三甲胺氧化物（TMAO），以及产生包括脱盐磷虾油提取物的磷虾油产品，极性脂质含量大于50 以干或无溶剂为基准，用于生物柴油生产的中性脂质流和虾青素。 炼油厂包括连续脱盐区，固定床极性脂质提取区，用于吸附中性脂质和虾青素，以提供极性脂质提取物流，其包含溶剂和极性脂质，并且基本上不含中性脂质和虾青素，以及虾青素分离区以回收 基本上是纯的虾青素并提供中性脂质流。 磷虾炼油厂的富集产品基本上不含TMAO和盐，并提供可用作膳食补充剂和药用添加剂的产品。
-
公开(公告)号：US09650333B2
公开(公告)日：2017-05-16
申请号：US15382555
申请日：2016-12-16
IPC分类号： C07C45/00 , C07C403/24
CPC分类号： C07C403/24 , C07C2601/10 , C07C2601/16 , C11B3/001 , C11B3/006 , C11B3/008 , C11B3/10
摘要： Disclosed is a chromatographic process complex for the refining of krill oil extract including desalting, removal of impurities such as trimethylamine oxide (TMAO), and the production of krill oil products including desalted krill oil extract, polar lipid products having polar lipid contents greater than 50 wt-% on a dry or solvent free basis, neutral lipid streams for biodiesel production and astaxanthin. The refinery includes a continuous desalting zone, a fixed bed polar lipid extraction zone to adsorb neutral lipids and astaxanthin to provide a polar lipid extract stream comprising solvent and polar lipids and being essentially free of neutral lipids and astaxanthin, and an astaxanthin separation zone to recover essentially pure astaxanthin and provide a neutral lipid stream. The enriched products of the krill oil refinery are essentially free of TMAO and salt and provide products which can be used as dietary supplements and as medicinal additives.
-
8.发明申请METHOD AND APPARATUS FOR THE EXTRACTION OF VITAMIN D METABOLITES FROM HUMAN PLASMA 有权从人类血浆中提取维生素D代谢物的方法和装置公开(公告)号：US20160025606A1
公开(公告)日：2016-01-28
申请号：US14340641
申请日：2014-07-25
发明人： Asha A. Oroskar , Xuejun Zang , Javier Ramirez
CPC分类号： G01N1/4055 , B01J39/05 , B01J39/07 , B01L3/50255 , B01L2200/0631 , B01L2300/0681 , B01L2300/069 , B01L2300/0829 , B01L2400/0487 , B01L2400/049 , G01N1/4005 , G01N33/82 , G01N2001/4016 , G01N2001/4061
摘要： This invention relates to a method and apparatus or kit for extracting major metabolites of vitamin D from human plasma or serum. More particularly, the invention provides for the extraction from human plasma or serum samples comprising vitamin D metabolites such as 1,25-dihydroxy vitamin D3, 25-hydroxy vitamin D2, and D3 from protein binding, removal of protein and phospholipids, and isolation of the metabolites using a combination of ion-exchange and Lewis acid mechanisms without the requirement to acidify the samples. The method and apparatus of the invention comprise a cartridge or plurality of cartridges comprising at least one protein crash frit, a strong cation exchanged sorbent, and an acidified alumina sorbent to provide higher recoveries of vitamin D metabolites than existing phospholipid depletion plate techniques. Accurately quantifying 1,25-dihydroxy vitamin D3 is useful in differential diagnosis of vitamin D-related diseases and for monitoring vitamin D therapy in patients with chronic renal disease.
摘要翻译： 本发明涉及用于从人血浆或血清中提取维生素D的主要代谢物的方法和装置或试剂盒。 更具体地，本发明提供从蛋白质结合，去除蛋白质和磷脂中分离包含维生素D代谢物如1,25-二羟基维生素D3,25-羟基维生素D2和D3的人血浆或血清样品的提取，以及分离 代谢物使用离子交换和路易斯酸结合的组合，而不需要酸化样品。 本发明的方法和装置包括一个或多个盒，其包括至少一种蛋白质崩溃玻璃料，强阳离子交换的吸附剂和酸化的氧化铝吸附剂，以提供比现有的磷脂消耗板技术更高的维生素D代谢物回收率。 精确量化1,25-二羟维生素D3可用于维生素D相关疾病的鉴别诊断和用于监测慢性肾病患者的维生素D治疗。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.024 秒)
