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    STING AGONISTIC COMPOUND
    1.
    发明公开
    STING AGONISTIC COMPOUND 审中-公开

    公开(公告)号：US20230151024A1

    公开(公告)日：2023-05-18

    申请号：US17916343

    申请日：2020-04-10

    Applicant: ONO PHARMACEUTICAL CO., LTD.

    Inventor： Ryosuke HANADA ,  Masaya KOKUBO ,  Masakuni KURONO ,  Kenichi KOUDA ,  Hiroshi HAGIYA

    IPC: C07D498/04 ,  C07F9/6561 ,  C07H13/12 ,  A61P35/00 ,  A61P1/00

    CPC classification number: C07D498/04 ,  C07F9/6561 ,  C07H13/12 ,  A61P35/00 ,  A61P1/00

    Abstract: The object of the present invention is to provide a drug containing a compound having an agonistic activity to STING as an active ingredient.
    As a result of intensive studies by the inventors of the present invention, the compound represented by the following general formula (I-1)




    [in the formula, all symbols represent the same meanings as described in the present specification.] or the like, having the agonistic activity to STING, as a substance capable of solving such objects, and this invention was completed.
    Since the compound represented by the general formula (I-1) or the like of the present invention has the agonistic activity to STING, it can be used as an active ingredient of an agent for suppressing the progression of, suppressing the recurrence of and/or treating cancer or infectious disease.

    CHEMOKINE RECEPTOR ANTAGONISTS AND USE THEREOF
    2.
    发明申请
    CHEMOKINE RECEPTOR ANTAGONISTS AND USE THEREOF 审中-公开
    化疗受体拮抗剂及其用途

    公开(公告)号：US20140072576A1

    公开(公告)日：2014-03-13

    申请号：US14075538

    申请日：2013-11-08

    Applicant: ONO PHARMACEUTICAL CO., LTD.

    Inventor： Masaya KOKUBO ,  Motoyuki TANAKA ,  Hiroshi OCHIAI ,  Yoshikazu TAKAOKA ,  Shiro SHIBAYAMA

    IPC: A61K31/695 ,  C07D233/64 ,  A61K45/06 ,  C07D471/10 ,  A61K31/435 ,  A61K31/5377 ,  C07F7/18 ,  A61K31/4178

    CPC classification number: A61K31/695 ,  A61K31/4178 ,  A61K31/435 ,  A61K31/5377 ,  A61K45/06 ,  C07D233/64 ,  C07D471/10 ,  C07F7/1804

    Abstract: The present invention relates to a compound represented by formula (I): wherein all symbols are as defined here, a salt thereof, a solvate thereof, or a prodrug thereof. The compound of the present invention has an antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, retinopathy, pulmonary fibrosis, rejection of transplanted organ, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiovascular disease, metabolic diseases, and cancerous diseases (for example, cancer, cancer metastasis, etc.), or an agent for regeneration therapy.

    Abstract translation: 本发明涉及由式（I）表示的化合物：其中所有符号如本文所定义，其盐，其溶剂化物或其前药。 本发明的化合物对CXCR4具有拮抗作用，因此可用作CXCR4介导的疾病的预防和/或治疗剂，例如炎性和免疫疾病（例如类风湿性关节炎，关节炎，视网膜病变，肺纤维化 ，移植器官的排斥等），过敏性疾病，感染（例如，人类免疫缺陷病毒感染，获得性免疫缺陷综合征等），精神神经病，脑疾病，心血管疾病，代谢疾病和癌性疾病（例如， 癌症，癌症转移等）或再生治疗剂。

    STING AGONISTIC COMPOUND
    5.
    发明申请
    STING AGONISTIC COMPOUND 有权

    公开(公告)号：US20210363166A1

    公开(公告)日：2021-11-25

    申请号：US17395643

    申请日：2021-08-06

    Applicant: ONO PHARMACEUTICAL CO., LTD.

    Inventor： Ryosuke HANADA ,  Masaya KOKUBO ,  Masakuni KURONO ,  Kenichi KOUDA ,  Hiroshi HAGIYA

    IPC: C07F9/6561

    Abstract: A drug or agent containing a compound having an agonistic activity to STING as an active ingredient, where the compound is represented by the following general formula (I-1): wherein all symbols represent the same meanings as described in the specification, and the compound can be used as an active ingredient of an agent for suppressing the progression of, suppressing the recurrence of and/or treating cancer or infectious disease.

    STING AGONISTIC COMPOUND
    6.
    发明申请
    STING AGONISTIC COMPOUND 有权

    公开(公告)号：US20210253615A1

    公开(公告)日：2021-08-19

    申请号：US17264179

    申请日：2019-10-10

    Applicant: ONO PHARMACEUTICAL CO., LTD.

    Inventor： Ryosuke HANADA ,  Masaya KOKUBO ,  Masakuni KURONO ,  Kenichi KOUDA ,  Hiroshi HAGIYA

    IPC: C07F9/6561

    Abstract: A drug or agent containing a compound having an agonistic activity to STING as an active ingredient, where the compound is represented by the following general formula (I-1): wherein all symbols represent the same meanings as described in the specification, and the compound can be used as an active ingredient of an agent for suppressing the progression of, suppressing the recurrence of and/or treating cancer or infectious disease.

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