公开(公告)号：US20230151024A1

公开(公告)日：2023-05-18

申请号：US17916343

申请日：2020-04-10

Applicant: ONO PHARMACEUTICAL CO., LTD.

Inventor： Ryosuke HANADA ,  Masaya KOKUBO ,  Masakuni KURONO ,  Kenichi KOUDA ,  Hiroshi HAGIYA

IPC: C07D498/04 ,  C07F9/6561 ,  C07H13/12 ,  A61P35/00 ,  A61P1/00

CPC classification number: C07D498/04 ,  C07F9/6561 ,  C07H13/12 ,  A61P35/00 ,  A61P1/00

Abstract: The object of the present invention is to provide a drug containing a compound having an agonistic activity to STING as an active ingredient.
As a result of intensive studies by the inventors of the present invention, the compound represented by the following general formula (I-1)




[in the formula, all symbols represent the same meanings as described in the present specification.] or the like, having the agonistic activity to STING, as a substance capable of solving such objects, and this invention was completed.
Since the compound represented by the general formula (I-1) or the like of the present invention has the agonistic activity to STING, it can be used as an active ingredient of an agent for suppressing the progression of, suppressing the recurrence of and/or treating cancer or infectious disease.

公开(公告)号：US20250034187A1

公开(公告)日：2025-01-30

申请号：US18912206

申请日：2024-10-10

Applicant: ONO PHARMACEUTICAL CO., LTD.

Inventor： Ryosuke HANADA ,  Masaya KOKUBO ,  Masakuni KURONO ,  Kenichi KOUDA ,  Hiroshi HAGIYA

IPC: C07F9/6561 ,  A61K31/661 ,  C07D498/04 ,  C07F9/06

Abstract: A drug or agent containing a compound having an agonistic activity to STING as an active ingredient, where the compound is represented by the following general formula (I-1): wherein all symbols represent the same meanings as described in the specification, and the compound can be used as an active ingredient of an agent for suppressing the progression of, suppressing the recurrence of and/or treating cancer or infectious disease.

公开(公告)号：US20230339992A1

公开(公告)日：2023-10-26

申请号：US18339506

申请日：2023-06-22

Applicant: ONO PHARMACEUTICAL CO., LTD.

Inventor： Ryosuke HANADA ,  Masaya KOKUBO ,  Masakuni KURONO ,  Kenichi KOUDA ,  Hiroshi HAGIYA

IPC: C07F9/6561 ,  C07F9/06 ,  C07D498/04

CPC classification number: C07F9/6561 ,  C07F9/062 ,  C07D498/04

Abstract: A drug or agent containing a compound having an agonistic activity to STING as an active ingredient, where the compound is represented by the following general formula (I-1):




wherein all symbols represent the same meanings as described in the specification, and the compound can be used as an active ingredient of an agent for suppressing the progression of, suppressing the recurrence of and/or treating cancer or infectious disease.

公开(公告)号：US20210363166A1

公开(公告)日：2021-11-25

申请号：US17395643

申请日：2021-08-06

Applicant: ONO PHARMACEUTICAL CO., LTD.

Inventor： Ryosuke HANADA ,  Masaya KOKUBO ,  Masakuni KURONO ,  Kenichi KOUDA ,  Hiroshi HAGIYA

IPC: C07F9/6561

Abstract: A drug or agent containing a compound having an agonistic activity to STING as an active ingredient, where the compound is represented by the following general formula (I-1): wherein all symbols represent the same meanings as described in the specification, and the compound can be used as an active ingredient of an agent for suppressing the progression of, suppressing the recurrence of and/or treating cancer or infectious disease.

公开(公告)号：US20210253615A1

公开(公告)日：2021-08-19

申请号：US17264179

申请日：2019-10-10

Applicant: ONO PHARMACEUTICAL CO., LTD.

Inventor： Ryosuke HANADA ,  Masaya KOKUBO ,  Masakuni KURONO ,  Kenichi KOUDA ,  Hiroshi HAGIYA

IPC: C07F9/6561

Abstract: A drug or agent containing a compound having an agonistic activity to STING as an active ingredient, where the compound is represented by the following general formula (I-1): wherein all symbols represent the same meanings as described in the specification, and the compound can be used as an active ingredient of an agent for suppressing the progression of, suppressing the recurrence of and/or treating cancer or infectious disease.