公开(公告)号：US20160116476A1

公开(公告)日：2016-04-28

申请号：US14981144

申请日：2015-12-28

Applicant: OLYMPUS CORPORATION

Inventor： Rie TAKEICHI ,  Nao SHIMADA ,  Hiromi SANUKI ,  Mari NAKATA ,  Masanobu KIYOHARA ,  Tetsuhide TAKEYAMA ,  Tomonori NAGAOKA

IPC: G01N33/574 ,  G01N21/29 ,  G01N33/68 ,  G01N21/31

CPC classification number: G01N33/57438 ,  A61B5/1032 ,  A61B5/4283 ,  A61B2010/0061 ,  G01N21/29 ,  G01N21/293 ,  G01N21/31 ,  G01N33/48 ,  G01N33/6872 ,  G01N2333/70503 ,  G01N2800/067

Abstract: Provided are a method for exclusively selecting a duodenal fluid sample having a high possibility of containing pancreatic fluid and favorable sample suitability for subjecting to detection of a pancreatic disease marker by evaluating the quality of the sample prior to detecting the pancreatic disease marker, and a method for detecting a pancreatic disease marker using a duodenal fluid sample selected according to that method. Namely, a method is provided for selecting a duodenal fluid sample for detecting a pancreatic disease marker, comprising: (a1) a step of comparing the color depth of a duodenal fluid sample with a prescribed standard color, and (b1) a step of determining that a duodenal fluid sample is subjected to a test for a pancreatic disease marker if the color depth thereof is equal to or higher than the standard color, but that the duodenal fluid sample is not subjected to a test for a pancreatic disease marker if the color depth thereof is lower than the standard color.

Abstract translation: 提供了一种专门选择具有高含有胰液的可能性的十二指肠液样品的方法，并且在检测胰腺疾病标记物之前通过评估样品的质量来评估对胰腺疾病标记物的检测的良好样品适合性的方法，以及方法 用于使用根据该方法选择的十二指肠液体样品检测胰腺疾病标记物。 即，提供一种选择用于检测胰腺疾病标记物的十二指肠液样品的方法，包括：（a1）将十二指肠液样品的颜色深度与规定的标准颜色进行比较的步骤，（b1）确定 如果十进制液体样品的颜色深度等于或高于标准颜色，则对十二指肠液样品进行胰腺疾病标记物的测试，但如果十进制液体样品的颜色 其深度低于标准颜色。

公开(公告)号：US20170096699A1

公开(公告)日：2017-04-06

申请号：US15382996

申请日：2016-12-19

Applicant: OLYMPUS CORPORATION

Inventor： Masanori ASAKURA ,  Tomonori NAGAOKA ,  Nao SHIMADA

IPC: C12Q1/37 ,  G01N33/58

CPC classification number: C12Q1/37 ,  G01N33/582 ,  G01N2333/96433 ,  G01N2333/96477

Abstract: A method is provided for evaluating the suitability of a duodenal fluid sample collected from an animal as a sample for detecting pancreatic fluid-derived components. The method comprises: (a) mixing a duodenal fluid sample with a chymotrypsin-specific substrate and measuring an amount of degradation the chymotrypsin-specific substrate by of the duodenal fluid sample, (b) mixing the duodenal fluid sample with a pepsin-specific substrate and measuring an amount of degradation of the pepsin-specific substrate by the duodenal fluid sample, and (c) evaluating that the duodenal fluid sample is suitable as a sample for detecting pancreatic fluid-derived components if the amount of degradation of the chymotrypsin-specific substrate by the duodenal fluid sample is higher than a prescribed threshold value and the amount of degradation of the pepsin-specific substrate by the duodenal fluid sample is lower than a prescribed threshold value, as being suitable as a sample for detecting pancreatic fluid-derived components.