公开(公告)号：US20230293650A1

公开(公告)日：2023-09-21

申请号：US17995780

申请日：2021-04-09

Applicant: Nykode Therapeutics ASA

Inventor： Agnete Brunsvik Fredriksen ,  Monika Sekelja ,  Karoline Schjetne ,  Stine Granum

IPC: A61K39/00 ,  A61P35/00

CPC classification number: A61K39/0011 ,  A61P35/00 ,  A61K2039/53 ,  A61K2039/6031 ,  A61K2039/70

Abstract: The present invention relates to an individualized therapeutic anticancer vaccine, methods of treatment of cancer wherein such an anticancer vaccine is used as well as methods for producing the vaccine.

公开(公告)号：US12059459B2

公开(公告)日：2024-08-13

申请号：US17557988

申请日：2021-12-21

Applicant: Nykode Therapeutics ASA

Inventor： Stine Granum ,  Elisabeth Stubsrud ,  Agnete Brunsvik Fredriksen

IPC: G01N31/00 ,  A61K39/00 ,  A61P35/00 ,  G01N33/53

CPC classification number: A61K39/0011 ,  A61P35/00 ,  A61K2039/53 ,  A61K2039/6031 ,  A61K2039/6056 ,  A61K2039/627 ,  A61K2039/64 ,  A61K2039/70

Abstract: The present invention relates to an anticancer vaccine which includes polynucleotides or polypeptides, methods of treatment of cancer wherein such an anticancer vaccine is used as well as methods for producing the vaccine. The vaccine includes a polynucleotide with a nucleotide sequence encoding a targeting unit, a dimerization unit, a first linker and an antigenic unit. The antigenic unit includes from 3 to 50 antigenic subunits separated by a second linker with each antigenic subunit having at least a part of a cancer neoepitope sequence. The vaccine can include a polypeptide encoded by the polynucleotide or a dimeric protein with two polypeptides encoded by the polynucleotide.

公开(公告)号：US20240350601A1

公开(公告)日：2024-10-24

申请号：US18738685

申请日：2024-06-10

Applicant: Nykode Therapeutics ASA

Inventor： Stine Granum ,  Elisabeth Stubsrud ,  Agnete Brunsvik Fredriksen

IPC: A61K39/00 ,  A61P35/00

CPC classification number: A61K39/0011 ,  A61P35/00 ,  A61K2039/53 ,  A61K2039/6031 ,  A61K2039/6056 ,  A61K2039/627 ,  A61K2039/64 ,  A61K2039/70

Abstract: The present invention relates to an anticancer vaccine which includes polynucleotides or polypeptides, methods of treatment of cancer wherein such an anticancer vaccine is used as well as methods for producing the vaccine. The vaccine includes a polynucleotide with a nucleotide sequence encoding a targeting unit, a dimerization unit, a first linker and an antigenic unit. The antigenic unit includes from 3 to 50 antigenic subunits separated by a second linker with each antigenic subunit having at least a part of a cancer neoepitope sequence. The vaccine can include a polypeptide encoded by the polynucleotide or a dimeric protein with two polypeptides encoded by the polynucleotide.

公开(公告)号：US20240252625A1

公开(公告)日：2024-08-01

申请号：US18560868

申请日：2022-05-10

Applicant: Nykode Therapeutics ASA

Inventor： Agnete Brunsvik Fredriksen ,  Audun Trygge Haugen Bersaas ,  Stine Granum ,  Heidi Myrset

IPC: A61K39/35 ,  A61K39/00 ,  A61K45/06 ,  A61P37/06 ,  C12N15/86

CPC classification number: A61K39/35 ,  A61K39/0008 ,  A61K45/06 ,  A61P37/06 ,  C12N15/86 ,  C12N2800/107 ,  C12N2800/60 ,  C12N2810/851 ,  C12N2840/206

Abstract: The present invention relates to vectors, such as DNA plasmids, comprising multiple nucleic acid sequences engineered to be co-expressed as separate molecules. Such separate molecules include a first polypeptide, wherein the first polypeptide comprises a targeting unit that targets antigen-presenting cells, a multimerization unit, such as dimerization unit, and an antigenic unit comprising one or more T cell epitopes of a self-antigen, an allergen, an alloantigen or a xenoantigen, and one or more immunoinhibitory compounds

公开(公告)号：US20240173391A1

公开(公告)日：2024-05-30

申请号：US18552383

申请日：2022-03-25

Applicant: Nykode Therapeutics ASA ,  Genentech Inc.

Inventor： Agnete Øvre Fredriksen ,  Karoline Schjetne ,  Stine Granum ,  Audun Trygge Haugen Bersaas ,  Ina Park Rhee ,  Siri Brinchmann-Hansen Torhaug

IPC: A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  C07K16/28

CPC classification number: A61K39/0011 ,  A61K39/39541 ,  A61K45/06 ,  A61P35/00 ,  C07K16/2803 ,  C07K16/2818 ,  C07K16/2827 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/6056 ,  A61K2039/627

Abstract: This invention relates to methods and kits for treating a subject having cancer, e.g. a patient, by administering to the subject an anticancer vaccine in combination with one or more checkpoint inhibitors.

公开(公告)号：US20220370579A1

公开(公告)日：2022-11-24

申请号：US17557988

申请日：2021-12-21

Applicant: NYKODE THERAPEUTICS ASA

Inventor： Stine Granum ,  Elisabeth Stubsrud ,  Agnete Brunsvik Fredriksen

IPC: A61K39/00 ,  A61P35/00

Abstract: The present invention relates to an anticancer vaccine which includes polynucleotides or polypeptides, methods of treatment of cancer wherein such an anticancer vaccine is used as well as methods for producing the vaccine. The vaccine includes a polynucleotide with a nucleotide sequence encoding a targeting unit, a dimerization unit, a first linker and an antigenic unit. The antigenic unit includes from 3 to 50 antigenic subunits separated by a second linker with each antigenic subunit having at least a part of a cancer neoepitope sequence. The vaccine can include a polypeptide encoded by the polynucleotide or a dimeric protein with two polypeptides encoded by the polynucleotide.