公开(公告)号：US20240252625A1

公开(公告)日：2024-08-01

申请号：US18560868

申请日：2022-05-10

Applicant: Nykode Therapeutics ASA

Inventor： Agnete Brunsvik Fredriksen ,  Audun Trygge Haugen Bersaas ,  Stine Granum ,  Heidi Myrset

IPC: A61K39/35 ,  A61K39/00 ,  A61K45/06 ,  A61P37/06 ,  C12N15/86

CPC classification number: A61K39/35 ,  A61K39/0008 ,  A61K45/06 ,  A61P37/06 ,  C12N15/86 ,  C12N2800/107 ,  C12N2800/60 ,  C12N2810/851 ,  C12N2840/206

Abstract: The present invention relates to vectors, such as DNA plasmids, comprising multiple nucleic acid sequences engineered to be co-expressed as separate molecules. Such separate molecules include a first polypeptide, wherein the first polypeptide comprises a targeting unit that targets antigen-presenting cells, a multimerization unit, such as dimerization unit, and an antigenic unit comprising one or more T cell epitopes of a self-antigen, an allergen, an alloantigen or a xenoantigen, and one or more immunoinhibitory compounds