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公开(公告)号：US20230365511A1
公开(公告)日：2023-11-16
申请号：US18164974
申请日：2023-02-06
申请人： Novartis AG , Gilead Sciences, Inc.
发明人： Zef Konst , Yipin Lu , Robert Joseph Moreau , Naomi Samadara Rajapaksa , Galen Shearn-Nance , David Charles Tully , Michael Robert Turner , Joseph Michael Young , Qian Zhao , Britton K. Corkey , Samuel E. Metobo
IPC分类号： C07D243/10
CPC分类号： C07D243/10
摘要： The invention provides compounds of Formula (I)
as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.-
公开(公告)号：US11667613B2
公开(公告)日：2023-06-06
申请号：US17030540
申请日：2020-09-24
申请人： Novartis AG , Gilead Sciences, Inc.
发明人： Zef Konst , Yipin Lu , Robert Joseph Moreau , Naomi Samadara Rajapaksa , Galen Shearn-Nance , David Charles Tully , Michael Robert Turner , Joseph Michael Young , Qian Zhao , Britton K. Corkey , Samuel E. Metobo
IPC分类号： C07D471/04 , C07D471/14 , A61K31/4162 , A61K31/437 , A61P31/22 , C07D243/10
CPC分类号： C07D243/10
摘要： The invention provides compounds of Formula (I)
as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.-
3.发明申请公开(公告)号：US20210403497A1
公开(公告)日：2021-12-30
申请号：US17209639
申请日：2021-03-23
发明人： Thomas Butler , Aesop Cho , Benjamin R. Graetz , Choung U. Kim , Samuel E. Metobo , Oliver L. Saunders , Andrew W. Waltman , Jie Xu , Lijun Zhang
摘要： Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.
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公开(公告)号：US20210024494A1
公开(公告)日：2021-01-28
申请号：US16923750
申请日：2020-07-08
发明人： Evangelos Aktoudianakis , Aesop Cho , Michael Graupe , Lateshkumar Thakorlal Lad , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Devan Naduthambi , Barton W. Phillips , Scott Preston Simonovich , Peiyuan Wang , William J. Watkins , Jie Xu , Kin Shing Yang , Christopher Allen Ziebenhaus
IPC分类号： C07D401/14 , A61K31/444 , A61K31/497 , A61K31/704 , A61K31/7068 , A61K39/395 , C07D471/08
摘要： Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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公开(公告)号：US20200157094A1
公开(公告)日：2020-05-21
申请号：US16660219
申请日：2019-10-22
发明人： Zhimin Du , Michael Graupe , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Eric Q. Parkhill , Barton W. Phillips , Scott P. Simonovich , Peiyuan Wang , Jie Xu , Christopher A. Ziebenhaus
IPC分类号： C07D471/04 , C07D513/04 , C07D401/12 , C07D413/10 , C07D217/04 , C07D401/14 , C07D471/08 , C07D487/04 , C07D495/04
摘要： Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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公开(公告)号：US11555029B2
公开(公告)日：2023-01-17
申请号：US16891880
申请日：2020-06-03
发明人： Evangelos Aktoudianakis , Aesop Cho , Zhimin Du , Michael Graupe , Lateshkumar Thakorlal Lad , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Prasenjit Kumar Mukherjee , Devan Naduthambi , Eric Q. Parkhill , Barton W. Phillips , Scott Preston Simonovich , Neil H. Squires , Peiyuan Wang , William J. Watkins , Jie Xu , Kin Shing Yang , Christopher Allen Ziebenhaus
IPC分类号： C07D403/14 , A61P31/20 , A61P35/02 , A61K31/496 , C07D519/00 , C07D241/20 , C07D487/10 , C07D405/14 , C07D487/08 , A61K31/497 , C07D491/107 , C07D241/18 , A61P35/00 , C07K16/28
摘要： Compounds of Formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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公开(公告)号：US20210053946A1
公开(公告)日：2021-02-25
申请号：US16891880
申请日：2020-06-03
发明人： Evangelos Aktoudianakis , Aesop Cho , Zhimin Du , Michael Graupe , Lateshkumar Thakorlal Lad , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Prasenjit Kumar Mukherjee , Devan Naduthambi , Eric Q. Parkhill , Barton W. Phillips , Scott Preston Simonovich , Neil H. Squires , Peiyuan Wang , William J. Watkins , Jie Xu , Kin Shing Yang , Christopher Allen Ziebenhaus
IPC分类号： C07D403/14 , A61P31/20 , A61P35/02 , A61K31/496 , C07D519/00 , C07D241/20 , C07D487/10 , C07D405/14 , C07D487/08 , A61K31/497 , C07D491/107 , C07D241/18 , A61P35/00
摘要： Compounds of Formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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公开(公告)号：US10899735B2
公开(公告)日：2021-01-26
申请号：US16388517
申请日：2019-04-18
申请人： Gilead Sciences, Inc
发明人： Evangelos Aktoudianakis , Aesop Cho , Zhimin Du , Michael Graupe , Lateshkumar Thakorlal Lad , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Prasenjit Kumar Mukherjee , Devan Naduthambi , Eric Q. Parkhill , Barton W. Phillips , Scott Preston Simonovich , Neil H. Squires , Peiyuan Wang , William J. Watkins , Jie Xu , Kin Shing Yang , Christopher Allen Ziebenhaus
IPC分类号： C07D401/10 , A61K31/444 , C07D401/04 , C07D401/12 , C07D401/14 , C07D487/10 , C07D519/00 , C07K16/28
摘要： Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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公开(公告)号：US20210017170A1
公开(公告)日：2021-01-21
申请号：US16911643
申请日：2020-06-25
发明人： Evangelos Aktoudianakis , Andrea Ambrosi , Sylvie M. Asselin , Florence J. Bachrach , Pavel R. Badalov , Gregory F. Chin , Stephen P. Lathrop , Willard Lew , Richard L. Mackman , Jeffrey E. Merit , Samuel E. Metobo , Michael R. Mish , Beau P. Pritchett , Hyung-Jung Pyun , Christopher S. Regens , Tiago Vieira , Xianghong Wang , Adam B. Weinstein , Todd A. Wenderski , Zehua Zheng
IPC分类号： C07D471/04 , C07D213/81 , C07D413/04
摘要： The present disclosure provides methods for preparing (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol or a salt thereof and related key intermediates.
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公开(公告)号：US20170342068A1
公开(公告)日：2017-11-30
申请号：US15596844
申请日：2017-05-16
发明人： Evangelos Aktoudianakis , Eda Canales , Elbert Chin , Kevin S. Currie , Ashley Anne Katana , Darryl Kato , John O. Link , Samuel E. Metobo , Roland D. Saito , Zheng-Yu Yang
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K31/5025
摘要： The present disclosure generally relates to compounds and pharmaceutical compositions which may be used in methods of treating a hepatitis B virus infection.
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