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公开(公告)号：US11613553B2
公开(公告)日：2023-03-28
申请号：US17198829
申请日：2021-03-11
发明人： Pavel R. Badalov , Stacy Bremner , Matthew R. Chin , Detian Gao , Nolan Griggs , Lars V. Heumann , Chiajen Lai , Robert R. Milburn , Sankar Mohan , Sean T. Neville , Bing Shi , Andrew C. Stevens , Nicholas A. J. Uhlig , Tiago Vieira , Todd A. Wenderski
摘要： The present disclosure generally describes methods of preparing 1′-cyano nucleosides, such as a compound of Formula (I). For example, the compound of Formula (I) can be prepared from a compound of Formula (II-a) in a flow reactor.
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公开(公告)号：US20220274985A1
公开(公告)日：2022-09-01
申请号：US17673141
申请日：2022-02-16
发明人： Andrea Ambrosi , Florence J. Bachrach , Pavel R. Badalov , Stephen P. Lathrop , Jeffrey E. Merit , Beau P. Pritchett , Christopher S. Regens , Tiago Vieira , Adam B. Weinstein , Todd A. Wenderski , Zehua Zheng
IPC分类号： C07D471/04 , C07D213/81 , C07D413/04
摘要： The present disclosure provides methods for preparing (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol or a salt thereof and related key intermediates.
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公开(公告)号：US11286257B2
公开(公告)日：2022-03-29
申请号：US16911643
申请日：2020-06-25
发明人： Andrea Ambrosi , Florence J. Bachrach , Pavel R. Badalov , Stephen P. Lathrop , Jeffrey E. Merit , Beau P. Pritchett , Christopher S. Regens , Tiago Vieira , Adam B. Weinstein , Todd A. Wenderski , Zehua Zheng
IPC分类号： C07D471/04 , C07D213/81 , C07D413/04
摘要： The present disclosure provides methods for preparing (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol or a salt thereof and related key intermediates.
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公开(公告)号：US20210017170A1
公开(公告)日：2021-01-21
申请号：US16911643
申请日：2020-06-25
发明人： Evangelos Aktoudianakis , Andrea Ambrosi , Sylvie M. Asselin , Florence J. Bachrach , Pavel R. Badalov , Gregory F. Chin , Stephen P. Lathrop , Willard Lew , Richard L. Mackman , Jeffrey E. Merit , Samuel E. Metobo , Michael R. Mish , Beau P. Pritchett , Hyung-Jung Pyun , Christopher S. Regens , Tiago Vieira , Xianghong Wang , Adam B. Weinstein , Todd A. Wenderski , Zehua Zheng
IPC分类号： C07D471/04 , C07D213/81 , C07D413/04
摘要： The present disclosure provides methods for preparing (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol or a salt thereof and related key intermediates.
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公开(公告)号：US20230295214A1
公开(公告)日：2023-09-21
申请号：US18108480
申请日：2023-02-10
发明人： Pavel R. Badalov , Stacy Bremner , Matthew R. Chin , Detian Gao , Nolan Griggs , Lars V. Heumann , Chiajen Lai , Robert R. Milburn , Sankar Mohan , Sean T. Neville , Bing Shi , Andrew C. Stevens , Nicholas A.J. Uhlig , Tiago Vieira , Todd A. Wenderski
摘要： The present disclosure generally describes methods of preparing 1′-cyano nucleosides, such as a compound of Formula (I). For example, the compound of Formula (I) can be prepared from a compound of Formula (II-a) in a flow reactor.
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公开(公告)号：US20210309689A1
公开(公告)日：2021-10-07
申请号：US17198829
申请日：2021-03-11
发明人： Pavel R. Badalov , Stacy Bremner , Matthew R. Chin , Detian Gao , Nolan Griggs , Lars V. Heumann , Chiajen Lai , Robert R. Milburn , Sankar Mohan , Sean T. Neville , Bing Shi , Andrew C. Stevens , Nicholas A.J. Uhlig , Tiago Vieira , Todd A. Wenderski
摘要： The present disclosure generally describes methods of preparing 1′-cyano nucleosides, such as a compound of Formula (I). For example, the compound of Formula (I) can be prepared from a compound of Formula (II-a) in a flow reactor.
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