公开(公告)号：US20230365511A1

公开(公告)日：2023-11-16

申请号：US18164974

申请日：2023-02-06

申请人： Novartis AG ,  Gilead Sciences, Inc.

发明人： Zef Konst ,  Yipin Lu ,  Robert Joseph Moreau ,  Naomi Samadara Rajapaksa ,  Galen Shearn-Nance ,  David Charles Tully ,  Michael Robert Turner ,  Joseph Michael Young ,  Qian Zhao ,  Britton K. Corkey ,  Samuel E. Metobo

IPC分类号： C07D243/10

CPC分类号： C07D243/10

摘要： The invention provides compounds of Formula (I)





as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.

公开(公告)号：US11667613B2

公开(公告)日：2023-06-06

申请号：US17030540

申请日：2020-09-24

申请人： Novartis AG ,  Gilead Sciences, Inc.

发明人： Zef Konst ,  Yipin Lu ,  Robert Joseph Moreau ,  Naomi Samadara Rajapaksa ,  Galen Shearn-Nance ,  David Charles Tully ,  Michael Robert Turner ,  Joseph Michael Young ,  Qian Zhao ,  Britton K. Corkey ,  Samuel E. Metobo

IPC分类号： C07D471/04 ,  C07D471/14 ,  A61K31/4162 ,  A61K31/437 ,  A61P31/22 ,  C07D243/10

CPC分类号： C07D243/10

摘要： The invention provides compounds of Formula (I)




as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.

公开(公告)号：US09926314B2

公开(公告)日：2018-03-27

申请号：US15220149

申请日：2016-07-26

申请人： NOVARTIS AG

发明人： Arnab Kumar Chatterjee ,  Advait Suresh Nagle ,  Prasuna Paraselli ,  Ravinder Reddy Kondreddi ,  Seh Yong Leong ,  Pranab Kumar Mishra ,  Robert Joseph Moreau ,  Jason Thomas Roland ,  Wei Lin Sandra Sim ,  Oliver Simon ,  Liying Jocelyn Tan ,  Bryan K S Yeung ,  Bin Zou ,  Venkatataiah Bollu

IPC分类号： C07D471/04 ,  C07D519/00 ,  A61K31/437 ,  A61K31/506 ,  A61K31/538 ,  A61K45/06

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/506 ,  A61K31/538 ,  A61K45/06 ,  C07D519/00

摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.

公开(公告)号：US09556169B2

公开(公告)日：2017-01-31

申请号：US14443609

申请日：2013-11-18

申请人： NOVARTIS AG

发明人： Arnab Kumar Chatterjee ,  Advait Suresh Nagle ,  Prasuna Paraselli ,  Ravinder Reddy Kondreddi ,  Seh Yong Leong ,  Pranab Kumar Mishra ,  Robert Joseph Moreau ,  Jason Thomas Roland ,  Wei Lin Sandra Sim ,  Oliver Simon ,  Jocelyn Liying Tan ,  Bryan K S Yeung ,  Bin Zou ,  Venkatataiah Bollu

IPC分类号： C07D471/04 ,  C07D519/00

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/506 ,  A61K31/538 ,  A61K45/06 ,  C07D519/00

摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.

摘要翻译： 本发明提供式I化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。 本发明还提供包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由疟原虫等疟原虫引起的疾病的病理和/或症状的方法。