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1.发明申请METHODS AND DEVICES FOR PASSIVE RESIDUAL LUNG VOLUME REDUCTION AND FUNCTIONAL LUNG VOLUME EXPANSION 有权被动残余肺容量减少和功能肺容量扩张的方法和装置公开(公告)号：US20090241964A1
公开(公告)日：2009-10-01
申请号：US12407709
申请日：2009-03-19
Applicant: Nikolai Aljuri , Rodney C. Perkins , Ryan Olivera , Hoang Nguyen , Sri Radhakrishnan , Niyazi Beyhan
Inventor： Nikolai Aljuri , Rodney C. Perkins , Ryan Olivera , Hoang Nguyen , Sri Radhakrishnan , Niyazi Beyhan
IPC: A61M16/00
CPC classification number: A61M16/0434 , A61B1/2676 , A61B5/0084 , A61B5/08 , A61B5/4836 , A61B17/12104 , A61B17/12136 , A61F2002/043 , A61M16/0003 , A61M16/0436 , A61M16/208 , A61M25/10 , A61M2016/0027 , A61M2016/003 , A61M2025/1052 , A61M2202/0208 , A61M2205/3334 , A61M2207/10 , Y10T29/49826
Abstract: The volume of a hyperinflated lung compartment is reduced by sealing a distal end of the catheter in an airway feeding the lung compartment. Air passes out of the lung compartment through a passage in the catheter while the patient exhales. A one-way flow element associated with the catheter prevents air from re-entering the lung compartment as the patient inhales. Over time, the pressure of regions surrounding the lung compartment cause it to collapse as the volume of air diminishes. Residual volume reduction effectively results in functional lung volume expansion. Optionally, the lung compartment may be sealed in order to permanently prevent air from re-entering the lung compartment. The invention further discloses a catheter with a transparent occlusion element at its tip that enables examination of the lung passageway through a viewing scope.
Abstract translation: 通过在进入肺隔室的气道中密封导管的远端来减少超膨胀的肺隔室的体积。 当患者呼气时，空气通过导管中的通道从肺隔间通过。 与导管相关联的单向流动元件防止空气在患者吸入时再次进入肺隔室。 随着时间的推移，随着空气体积的减小，肺室周围的区域压力会使其崩溃。 残余体积减少有效地导致功能性肺容积扩张。 任选地，肺隔室可以被密封以便永久地防止空气重新进入肺隔室。 本发明还公开了一种在其顶端具有透明阻塞元件的导管，其能够通过观察范围检查肺通道。
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2.发明申请MINIMALLY INVASIVE METHODS AND DEVICES FOR THE TREATMENT OF PROSTATE DISEASES 有权最小的入侵方法和用于治疗前列腺疾病的装置公开(公告)号：US20090018533A1
公开(公告)日：2009-01-15
申请号：US11968445
申请日：2008-01-02
Applicant: Rodney C. Perkins , Nikolai Aljuri
Inventor： Rodney C. Perkins , Nikolai Aljuri
IPC: A61B18/20 , A61B17/3203 , A61B18/18
CPC classification number: A61B18/1485 , A61B18/04 , A61B18/24 , A61B2017/00274 , A61B2018/00166 , A61B2018/00196 , A61B2018/00202 , A61B2018/00285 , A61B2018/00517 , A61B2018/00547 , A61B2018/00577 , A61B2018/00583 , A61B2018/00946 , A61B2018/00952 , A61B2018/046 , A61B2018/1472 , A61B2018/1497 , A61B2018/1861 , A61B2018/2238 , A61B2018/2283 , A61B2090/033 , A61B2218/002 , A61B2218/007
Abstract: Methods and systems for resecting and debulking prostatic tissue to utilize a shaft carrying an energy source. The shaft is anchored by a balloon or other structure expanded in the bladder, and the energy source is capable of directing ablative energy radially outwardly from the urethra, where the energy source will be moved in order to remove a pre-defined volume of prostatic tissue.
Abstract translation: 用于切除和减压前列腺组织以利用承载能量源的轴的方法和系统。 轴由气囊或其他在膀胱中膨胀的结构锚定，能量源能够从尿道径向向外引导消融能量，其中能量源将被移动以去除预定体积的前列腺组织 。
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公开(公告)号：US20080228130A1
公开(公告)日：2008-09-18
申请号：US11684950
申请日：2007-03-12
Applicant: Nikolai Aljuri , Jose G. Venegas , Ajit Nair , Rodney C. Perkins
Inventor： Nikolai Aljuri , Jose G. Venegas , Ajit Nair , Rodney C. Perkins
IPC: A61M16/00
CPC classification number: A61M16/04 , A61M16/0404 , A61M16/0434 , A61M16/0459 , A61M16/0479 , A61M16/0486 , A61M2202/0208 , A61M2202/025 , A61M2202/0275 , A61M2202/0283 , A61M2202/064
Abstract: The lateral flow between adjacent lung segments is occluded by blocking collateral flow channels with particles. A gas flow is established from one lung segment through the flow channels in an intermediate fibrous septum, and out through the adjacent lung segment. Particles entrained in the gas flow become lodged in the collateral flow channels to eventually block flow.
Abstract translation: 相邻肺段之间的侧向流动通过阻塞具有颗粒的侧支流动通道而闭塞。 从一个肺段通过中间纤维隔膜中的流动通道建立气流，并通过相邻的肺段排出。 携带在气流中的颗粒变成滞留在侧流通道中以最终阻止流动。
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4.发明申请METHODS AND DEVICES TO INDUCE CONTROLLED ATELECTASIS AND HYPOXIC PULMONARY VASOCONSTRICTION 有权诱导控制性输血和高血压血管造影的方法和装置公开(公告)号：US20070225747A1
公开(公告)日：2007-09-27
申请号：US11682986
申请日：2007-03-07
Applicant: Rodney C. Perkins , Nikolai Aljuri , Ajit Nair
Inventor： Rodney C. Perkins , Nikolai Aljuri , Ajit Nair
CPC classification number: A61F2/04 , A61B17/12104 , A61F2/95 , A61F2002/043 , A61F2002/068
Abstract: Lung conditions are treated by implanting a flow restrictor in a passageway upstream from a diseased lung segment. The restrictor will create an orifice at the implantation site which inhibits air exchange with the segment to induce controlled atelectasis and/or hypoxia. Controlled atelectasis can induce collapse of the diseased segment with a reduced risk of pneumothorax. Hypoxia can promote gas exchange with non-isolated, healthy regions of the lung even in the absence of lung collapse.
Abstract translation: 通过将流量限制器植入患病肺段上游的通道来治疗肺部疾病。 限流器将在植入部位产生一个孔口，该孔口可抑制与该部分的空气交换以诱导受控的肺不张和/或缺氧。 控制性肺不张可以诱发患病部位的塌陷，降低气胸风险。 即使没有肺塌陷，缺氧也可以促进与非孤立，健康的肺部区域的气体交换。
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5.发明授权Methods and devices for passive residual lung volume reduction and functional lung volume expansion 有权被动残余肺容积减少和功能性肺容积扩张的方法和装置公开(公告)号：US09050094B2
公开(公告)日：2015-06-09
申请号：US12407709
申请日：2009-03-19
Applicant: Nikolai Aljuri , Rodney C. Perkins , Ryan Olivera , Hoang Nguyen , Sri Radhakrishnan , Niyazi Beyhan
Inventor： Nikolai Aljuri , Rodney C. Perkins , Ryan Olivera , Hoang Nguyen , Sri Radhakrishnan , Niyazi Beyhan
CPC classification number: A61M16/0434 , A61B1/2676 , A61B5/0084 , A61B5/08 , A61B5/4836 , A61B17/12104 , A61B17/12136 , A61F2002/043 , A61M16/0003 , A61M16/0436 , A61M16/208 , A61M25/10 , A61M2016/0027 , A61M2016/003 , A61M2025/1052 , A61M2202/0208 , A61M2205/3334 , A61M2207/10 , Y10T29/49826
Abstract: The volume of a hyperinflated lung compartment is reduced by sealing a distal end of the catheter in an airway feeding the lung compartment. Air passes out of the lung compartment through a passage in the catheter while the patient exhales. A one-way flow element associated with the catheter prevents air from re-entering the lung compartment as the patient inhales. Over time, the pressure of regions surrounding the lung compartment cause it to collapse as the volume of air diminishes. Residual volume reduction effectively results in functional lung volume expansion. Optionally, the lung compartment may be sealed in order to permanently prevent air from re-entering the lung compartment. The invention further discloses a catheter with a transparent occlusion element at its tip that enables examination of the lung passageway through a viewing scope.
Abstract translation: 通过在进入肺隔室的气道中密封导管的远端来减少超膨胀的肺隔室的体积。 当患者呼气时，空气通过导管中的通道从肺隔间通过。 与导管相关联的单向流动元件防止空气在患者吸入时再次进入肺隔室。 随着时间的推移，随着空气体积的减小，肺室周围的区域压力会使其崩溃。 残余体积减少有效地导致功能性肺容积扩张。 任选地，肺隔室可以被密封以便永久地防止空气重新进入肺隔室。 本发明还公开了一种在其顶端具有透明阻塞元件的导管，其能够通过观察范围检查肺通道。
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Patent Agency Ranking
公开(公告)号：US20130245484A1
公开(公告)日：2013-09-19
申请号：US13891719
申请日：2013-05-10
Applicant: Nikolai Aljuri , Anthony Wondka , George Surjan , Kirk Davis , Peter Soltesz , Rodney C. Perkins
Inventor： Nikolai Aljuri , Anthony Wondka , George Surjan , Kirk Davis , Peter Soltesz , Rodney C. Perkins
CPC classification number: A61B5/085 , A61B5/055 , A61B5/08 , A61B5/0813 , A61B5/087 , A61B5/4836 , A61B5/4851 , A61B5/6853 , A61B5/7278 , A61M16/04 , A61M16/0404 , A61M16/0434 , A61M2016/0413
Abstract: Minimally invasive methods, systems and devices are provided for qualitatively and quantitatively assessing collateral ventilation in the lungs. In particular, collateral ventilation of a target compartment within a lung of a patient is assessed by advancement of a catheter through the tracheobronchial tree to a feeding bronchus of the target compartment. The feeding bronchus is occluded by the catheter and a variety of measurements are taken with the use of the catheter in a manner which is of low risk to the patient. Examples of such measurements include but are not limited to flow rate, volume and pressure. These measurements are used to determine the presence of collateral ventilation and to quantify such collateral ventilation.
Abstract translation: 提供了微创方法，系统和装置，用于定性和定量评估肺中的旁路通气。 特别地，通过将导管穿过气管支气管树推进到目标隔室的进食支气管来评估患者的肺内的目标隔室的侧支通气。 供血支气管被导管阻塞，并且以对患者的风险低的方式使用导管进行各种测量。 这种测量的实例包括但不限于流量，体积和压力。 这些测量用于确定侧支通气的存在并量化此类旁路通气。
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7.发明申请METHODS AND DEVICES FOR PASSIVE RESIDUAL LUNG VOLUME REDUCTION AND FUNCTIONAL LUNG VOLUME EXPANSION 有权被动残余肺容量减少和功能肺容量扩张的方法和装置公开(公告)号：US20110152678A1
公开(公告)日：2011-06-23
申请号：US12820547
申请日：2010-06-22
Applicant: Nikolai Aljuri , Rodney C. Perkins , Niyazi Beyhan
Inventor： Nikolai Aljuri , Rodney C. Perkins , Niyazi Beyhan
CPC classification number: A61B17/12104 , A61B5/055 , A61B5/08 , A61B5/0813 , A61B5/085 , A61B5/6853 , A61B6/03 , A61B6/032 , A61B17/1204 , A61B17/12136 , A61B2017/00022 , A61M16/0434 , A61M16/208 , A61M25/10 , A61M2016/0027 , A61M2016/003 , A61M2025/1052 , A61M2205/3303 , A61M2205/3334 , A61M2205/3344 , A61M2210/1035 , A61M2230/46
Abstract: The volume of a hyperinflated lung compartment is reduced by sealing a distal end of the catheter in an airway feeding the lung compartment. Air passes out of the lung compartment through a passage in the catheter while the patient exhales. A one-way flow element associated with the catheter prevents air from re-entering the lung compartment as the patient inhales. Over time, the pressure of regions surrounding the lung compartment cause it to collapse as the volume of air diminishes. Residual volume reduction effectively results in functional lung volume expansion. Optionally, the lung compartment may be sealed in order to permanently prevent air from re-entering the lung compartment.
Abstract translation: 通过在进入肺隔室的气道中密封导管的远端来减少超膨胀的肺隔室的体积。 当患者呼气时，空气通过导管中的通道从肺隔间通过。 与导管相关联的单向流动元件防止空气在患者吸入时再次进入肺隔室。 随着时间的推移，随着空气体积的减小，肺室周围的区域压力会使其崩溃。 残余体积减少有效地导致功能性肺容积扩张。 任选地，肺隔室可以被密封以便永久地防止空气重新进入肺隔室。
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8.发明授权公开(公告)号：US07882841B2
公开(公告)日：2011-02-08
申请号：US11968445
申请日：2008-01-02
Applicant: Nikolai Aljuri , Rodney C. Perkins
Inventor： Nikolai Aljuri , Rodney C. Perkins
IPC: A61B19/00
CPC classification number: A61B18/1485 , A61B18/04 , A61B18/24 , A61B2017/00274 , A61B2018/00166 , A61B2018/00196 , A61B2018/00202 , A61B2018/00285 , A61B2018/00517 , A61B2018/00547 , A61B2018/00577 , A61B2018/00583 , A61B2018/00946 , A61B2018/00952 , A61B2018/046 , A61B2018/1472 , A61B2018/1497 , A61B2018/1861 , A61B2018/2238 , A61B2018/2283 , A61B2090/033 , A61B2218/002 , A61B2218/007
Abstract: Methods and systems for resecting and debulking prostatic tissue to utilize a shaft carrying an energy source. The shaft is anchored by a balloon or other structure expanded in the bladder, and the energy source is capable of directing ablative energy radially outwardly from the urethra, where the energy source will be moved in order to remove a pre-defined volume of prostatic tissue.
Abstract translation: 用于切除和减压前列腺组织以利用承载能量源的轴的方法和系统。 轴由气囊或其他在膀胱中膨胀的结构锚定，能量源能够从尿道径向向外引导消融能量，其中能量源将被移动以去除预定体积的前列腺组织 。
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公开(公告)号：US20090227998A1
公开(公告)日：2009-09-10
申请号：US12399585
申请日：2009-03-06
Applicant: Nikolai Aljuri , Rodney C. Perkins
Inventor： Nikolai Aljuri , Rodney C. Perkins
CPC classification number: A61B18/20 , A61B17/32037 , A61B18/24 , A61B2017/00274 , A61B2018/00547 , A61B2018/00565 , A61B2018/00577 , A61B2018/00601 , A61B2018/206 , A61C1/0046 , A61C17/0202
Abstract: Methods and systems for modifying tissue use a pressurized fluid stream carrying coherent light energy. The methods and systems may be used for resecting and debulking soft and hard biological tissues. The coherent light is focused within a stream of fluid to deliver energy to the tissue to be treated.
Abstract translation: 用于修改组织的方法和系统使用携带相干光能的加压流体流。 方法和系统可用于切割和减粘软和硬的生物组织。 相干光聚焦在流体流中以将能量传递到待治疗的组织。
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10.发明申请METHODS AND DEVICES FOR PASSIVE RESIDUAL LUNG VOLUME REDUCTION AND FUNCTIONAL LUNG VOLUME EXPANSION 审中-公开被动残余肺容量减少和功能肺容量扩张的方法和装置公开(公告)号：US20080228137A1
公开(公告)日：2008-09-18
申请号：US11685008
申请日：2007-03-12
Applicant: Nikolai Aljuri , Rodney C. Perkins
Inventor： Nikolai Aljuri , Rodney C. Perkins
IPC: A61M25/10
CPC classification number: A61M16/0434 , A61B1/2676 , A61B5/0084 , A61B5/08 , A61B5/4836 , A61B17/12104 , A61B17/12136 , A61F2002/043 , A61M16/0003 , A61M16/0436 , A61M16/208 , A61M25/10 , A61M2016/0027 , A61M2016/003 , A61M2025/1052 , A61M2202/0208 , A61M2205/3334 , A61M2207/10 , Y10T29/49826
Abstract: The volume of a hyperinflated lung compartment is reduced by sealing a distal end of the catheter in an airway feeding the lung compartment. Air passes out of the lung compartment through a passage in the catheter while the patient exhales. A one-way flow element associated with the catheter prevents air from re-entering the lung compartment as the patient inhales. Over time, the pressure of regions surrounding the lung compartment cause it to collapse as the volume of air diminishes. Residual volume reduction effectively results in functional lung volume expansion. Optionally, the lung compartment may be sealed in order to permanently prevent air from re-entering the lung compartment.
Abstract translation: 通过在进入肺隔室的气道中密封导管的远端来减少超膨胀的肺隔室的体积。 当患者呼气时，空气通过导管中的通道从肺隔间通过。 与导管相关联的单向流动元件防止空气在患者吸入时再次进入肺隔室。 随着时间的推移，随着空气体积的减小，肺室周围的区域压力会使其崩溃。 残余体积减少有效地导致功能性肺容积扩张。 任选地，肺隔室可以被密封以便永久地防止空气重新进入肺隔室。
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