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公开(公告)号：US20050037093A1
公开(公告)日：2005-02-17
申请号：US10484321
申请日：2002-08-02
Applicant: Nigel Benjamin
Inventor： Nigel Benjamin
IPC: A61K9/06 , A61K8/19 , A61K9/00 , A61K9/10 , A61K31/04 , A61K31/19 , A61K31/192 , A61K31/194 , A61K31/375 , A61K31/60 , A61K33/00 , A61K47/04 , A61K47/12 , A61K47/32 , A61K47/38 , A61P17/00 , A61P31/10 , A61Q3/00
CPC classification number: A61Q3/00 , A61K8/19 , A61K9/0012 , A61K31/04 , A61K33/00 , A61K47/12 , A61K47/32 , A61K47/38
Abstract: Nitrogen oxide generating compositions are useful in the treatment of subungual infections, as NO has surprisingly been found to be able to penetrate the nail to exert an anti-fungal effect.
Abstract translation: 产生氧化氮的组合物可用于治疗亚临床感染，因为令人惊奇地发现，NO能够穿透指甲以发挥抗真菌作用。
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公开(公告)号：US09381381B2
公开(公告)日：2016-07-05
申请号：US12455141
申请日：2009-05-28
Applicant: Nigel Benjamin
Inventor： Nigel Benjamin
CPC classification number: A61Q3/00 , A61K8/19 , A61K9/0012 , A61K31/04 , A61K33/00 , A61K47/12 , A61K47/32 , A61K47/38
Abstract: Nitrogen oxide generating compositions are useful in the treatment of subungual infections, as NO has surprisingly been found to be able to penetrate the nail to exert an anti-fungal effect.
Abstract translation: 产生氧化氮的组合物可用于治疗亚临床感染，因为令人惊奇地发现，NO能够穿透指甲以发挥抗真菌作用。
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公开(公告)号：US20100129474A1
公开(公告)日：2010-05-27
申请号：US12441977
申请日：2007-09-24
Applicant: Nigel Benjamin , Nicholas Jose Talbot , Michael John Kershaw , Paul Graham Winyard
Inventor： Nigel Benjamin , Nicholas Jose Talbot , Michael John Kershaw , Paul Graham Winyard
CPC classification number: A01N59/00 , A01N37/36 , A01N2300/00
Abstract: A method for the control of microorganisms, fungi or oomycetes in agriculture, said method comprising applying to plants or to the environment thereof, an anti-microbial, anti-fungal or anti-oomycetes effective amount of a combination of: (i) an agriculturally acceptable acidifying agent, and (ii) an agriculturally acceptable source of nitrite ions or a nitrate precursor thereof, wherein the combination of (i) and (ii) acts as a source of nitric oxide. Systems and compositions for use in this method are also described and claimed.
Abstract translation: 一种用于控制农业中的微生物，真菌或卵菌的方法，所述方法包括向植物或其环境施用抗微生物，抗真菌或抗卵菌的有效量的组合：（i）农业上 可接受的酸化剂，和（ii）农业上可接受的亚硝酸根离子源或其硝酸盐前体，其中（i）和（ii）的组合用作一氧化氮源。 还描述和要求保护用于该方法的系统和组合物。
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公开(公告)号：US08128964B2
公开(公告)日：2012-03-06
申请号：US10363439
申请日：2001-08-30
Applicant: Arthur T. Tucker , Nigel Benjamin
Inventor： Arthur T. Tucker , Nigel Benjamin
IPC: A01N59/00
CPC classification number: A61K9/06 , A61K9/0014 , A61K47/02 , A61K47/22 , Y02A50/491
Abstract: A pharmaceutically delivery system is described comprising a pharmaceutically active agent and acidified nitrite as an agent to produce local production of nitric oxide at the skin surface. The dosage form may be in any pharmaceutically acceptable carrier means and comprises an acidifying agent adapted to reduce the pH at the environment. In one embodiment, a barrier consisting of a membrane allows diffusions of the anaesthetic and nitrite ions while preventing direct contact of the skin and acidifying agent.
Abstract translation: 描述了药物递送系统，其包含药物活性剂和酸化亚硝酸盐作为试剂以在皮肤表面产生局部产生一氧化氮。 剂型可以是任何药学上可接受的载体，并且包含适于降低环境pH值的酸化剂。 在一个实施方案中，由膜组成的屏障允许麻醉剂和亚硝酸根离子的扩散，同时防止皮肤和酸化剂的直接接触。
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5.发明申请PHARMACEUTICAL COMPOSITION CONTAINING NITRATE SOURCE AND AN ACIDIFYING AGENT FOR TREATING SKIN ISCHAEMIA 审中-公开含有硝酸盐的药物组合物和用于治疗皮肤的化学剂ISCHAEMIA公开(公告)号：US20080226751A1
公开(公告)日：2008-09-18
申请号：US12035855
申请日：2008-02-22
Applicant: Arthur T. Tucker , Nigel Benjamin
Inventor： Arthur T. Tucker , Nigel Benjamin
CPC classification number: A61K47/12 , A61K33/00 , A61K45/06 , A61K31/19 , A61K2300/00
Abstract: The use of acidified nitrate as an agent to produce local production of nitrate oxide at the skin surface is described in the treatment of peripheral ischaemia and associated conditions. The dosage form may be in any pharmaceutically acceptable carrier means and comprises an acidifying agent adapted to reduce the pH at the environment. A barrier consisting of a membrane allows diffusions of the nitrate ions while preventing direct contact of the skin and acidifying agent. Amongst the many potential applications for the invention is the management of chronic skin wounds, peripheral ischaemia conditions such as Raynaud's phenomenon. Compositions and methods of use for these applications are described.
Abstract translation: 在外周缺血和相关病症的治疗中描述了使用酸化的硝酸盐作为药剂在皮肤表面产生局部产生硝酸氧化物的药剂。 剂型可以是任何药学上可接受的载体，并且包含适于降低环境pH值的酸化剂。 由膜构成的屏障允许硝酸根离子的扩散，同时防止皮肤和酸化剂的直接接触。 本发明的许多潜在应用之一是管理慢性皮肤伤口，外周缺血症状如雷诺现象。 描述这些应用的组合物和使用方法。
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Patent Agency Ranking
6.发明申请Pharmaceutical composition containing nitrate source and an acidifying agent for treating skin ischaemia 审中-公开含有硝酸盐的药物组合物和用于治疗皮肤局部缺血的酸化剂公开(公告)号：US20050142218A1
公开(公告)日：2005-06-30
申请号：US11065813
申请日：2005-02-25
Applicant: Arthur Tucker , Nigel Benjamin
Inventor： Arthur Tucker , Nigel Benjamin
CPC classification number: A61K9/0014 , A61K33/00 , A61K33/04 , A61K47/12
Abstract: The use of acidified nitrate as an agent to produce local production of nitrate oxide at the skin surface is described in the treatment of peripheral ischaemia and associated conditions. The dosage form may be in any pharmaceutically acceptable carrier means and comprises an acidifying agent adapted to reduce the pH at the environment. A barrier consisting of a membrane allows diffusions of the nitrate ions while preventing direct contact of the skin and acidifying agent. Amongst the many potential applications for the invention is the management of chronic skin wounds, peripheral ischaemia conditions such as Raynaud's phenomenon. Compositions and methods of use for these applications are described.
Abstract translation: 在外周缺血和相关病症的治疗中描述了使用酸化的硝酸盐作为药剂在皮肤表面产生局部产生硝酸氧化物的药剂。 剂型可以是任何药学上可接受的载体，并且包含适于降低环境pH值的酸化剂。 由膜构成的屏障允许硝酸根离子的扩散，同时防止皮肤和酸化剂的直接接触。 本发明的许多潜在应用之一是管理慢性皮肤伤口，外周缺血症状如雷诺现象。 描述这些应用的组合物和使用方法。
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公开(公告)号：US06709681B2
公开(公告)日：2004-03-23
申请号：US09330654
申请日：1999-06-11
Applicant: Nigel Benjamin , Hamish Dougall , Anthony Ormerod
Inventor： Nigel Benjamin , Hamish Dougall , Anthony Ormerod
IPC: A61K3300
CPC classification number: A61K33/00 , A01N59/00 , A61K9/0014 , A61K47/12 , Y02A50/409 , Y02A50/473 , Y02A50/475 , Y10S514/858 , Y10S514/859 , Y10S514/865 , Y10S514/887 , Y10S514/931 , Y10S514/932 , Y10S514/933 , Y10S514/934 , A01N2300/00 , A61K2300/00
Abstract: The present invention provides a dosage form for the treatment of bacterial, viral or fungal conditions which comprises, a pharmaceutically acceptable acidifying agent in an amount sufficient to reduce the pH at an environment of use to below pH4, and a pharmaceutically acceptable source of nitrite ions or a nitrate precursor therefor; wherein said acidifying agent and said source of nitrite ions or nitrate precursor are separately disposed in respective pharmaceutically acceptable carriers for admixture at the intended environment of use to release NO or NO2 ions. The invention also provides delivery systems for the topical medicament.
Abstract translation: 本发明提供了用于治疗细菌，病毒或真菌病症的剂型，其包含药学上可接受的酸度剂，其用量足以将pH降至低于pH4的环境，以及药学上可接受的亚硝酸根离子源 或其硝酸盐前体; 其中所述酸化剂和所述亚硝酸根离子或硝酸盐前体源分别设置在各自的药学上可接受的载体中，用于在预期使用环境中混合以释放NO或NO 2离子。 本发明还提供了用于局部药物的递送系统。
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公开(公告)号：US20120183595A1
公开(公告)日：2012-07-19
申请号：US13360601
申请日：2012-01-27
Applicant: Arthur T. Tucker , Nigel Benjamin
Inventor： Arthur T. Tucker , Nigel Benjamin
CPC classification number: A61K9/06 , A61K9/0014 , A61K47/02 , A61K47/22 , Y02A50/409 , Y02A50/411 , Y02A50/491
Abstract: A pharmaceutically delivery system is described comprising a pharmaceutically active agent and acidified nitrite as an agent to produce local production of nitric oxide at the skin surface. The dosage form may be in any pharmaceutically acceptable carrier means and comprises an acidifying agent adapted to reduce the pH at the environment. In one embodiment, a barrier consisting of a membrane allows diffusions of the anaesthetic and nitrite ions while preventing direct contact of the skin and acidifying agent.
Abstract translation: 描述了药物递送系统，其包含药物活性剂和酸化亚硝酸盐作为试剂以在皮肤表面产生局部产生一氧化氮。 剂型可以是任何药学上可接受的载体，并且包含适于降低环境pH值的酸化剂。 在一个实施方案中，由膜组成的屏障允许麻醉剂和亚硝酸根离子的扩散，同时防止皮肤和酸化剂的直接接触。
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公开(公告)号：US08114442B2
公开(公告)日：2012-02-14
申请号：US12231555
申请日：2008-09-03
Applicant: Arthur T. Tucker , Nigel Benjamin
Inventor： Arthur T. Tucker , Nigel Benjamin
IPC: A01N59/00
CPC classification number: A61K9/06 , A61K9/0014 , A61K47/02 , A61K47/22 , Y02A50/491
Abstract: A pharmaceutically delivery system and method of use therefor are described comprising a pharmaceutically active agent and acidified nitrite as an agent to produce local production of nitric oxide at the skin surface. The dosage form may be in any pharmaceutically acceptable carrier means and comprises an acidifying agent adapted to reduce the pH at the environment. In one embodiment, a barrier consisting of a membrane allows diffusions of the anaesthetic and nitrite ions while preventing direct contact of the skin and acidifying agent.
Abstract translation: 本发明描述了一种药物输送系统及其使用方法，其包含药物活性剂和酸化的亚硝酸盐作为在皮肤表面产生局部产生一氧化氮的药剂。 剂型可以是任何药学上可接受的载体，并且包含适于降低环境pH值的酸化剂。 在一个实施方案中，由膜组成的屏障允许麻醉剂和亚硝酸根离子的扩散，同时防止皮肤和酸化剂的直接接触。
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公开(公告)号：US20100015253A1
公开(公告)日：2010-01-21
申请号：US12455141
申请日：2009-05-28
Applicant: Nigel Benjamin
Inventor： Nigel Benjamin
IPC: A61K33/00
CPC classification number: A61Q3/00 , A61K8/19 , A61K9/0012 , A61K31/04 , A61K33/00 , A61K47/12 , A61K47/32 , A61K47/38
Abstract: Nitrogen oxide generating compositions are useful in the treatment of subungual infections, as NO has surprisingly been found to be able to penetrate the nail to exert an anti-fungal effect.
Abstract translation: 产生氧化氮的组合物可用于治疗亚临床感染，因为令人惊奇地发现，NO能够穿透指甲以发挥抗真菌作用。
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