公开(公告)号：US11492348B2

公开(公告)日：2022-11-08

申请号：US17046746

申请日：2019-04-09

Applicant: Neuropore Therapies, Inc.

Inventor： Emily M. Stocking ,  Wolfgang J. Wrasidlo

IPC: C07D413/14 ,  C07D413/10 ,  C07D413/12

Abstract: The present disclosure relates to tri-substituted aryl and heteroaryl derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for modulating autophagy or preventing, reversing, slowing or inhibiting the PI3K-AKT-MTOR pathway, and methods of treating diseases that are associated with autophagy or the PI3K-AKT-MTOR pathway.

公开(公告)号：US11299487B2

公开(公告)日：2022-04-12

申请号：US16830110

申请日：2020-03-25

Applicant: Neuropore Therapies, Inc.

Inventor： Srinivasa Reddy Natala ,  Wolfgang J. Wrasidlo ,  Emily M. Stocking

IPC: C07D417/10 ,  C07C235/56 ,  C07D207/06 ,  C07D211/10 ,  C07D231/12 ,  C07D265/30 ,  C07D265/36 ,  C07D401/06 ,  C07D401/10 ,  C07D403/10 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/10 ,  C07D413/06 ,  C07D413/10 ,  C07D413/14 ,  C07D471/08 ,  C07D487/08 ,  C07D498/02

Abstract: The present disclosure relates to substituted aryl and heteroaryl compounds, pharmaceutical compositions comprising such compounds, and use of such compounds in methods of treatment or in medicaments for treatment of inflammatory diseases and certain neurological disorders that are related to inflammatory signaling processes, including but not limited to misfolded proteins.

公开(公告)号：US12049462B2

公开(公告)日：2024-07-30

申请号：US17982425

申请日：2022-11-07

Applicant: Neuropore Therapies, Inc.

Inventor： Emily M. Stocking ,  Wolfgang J. Wrasidlo

IPC: C07D413/14 ,  C07D413/10 ,  C07D413/12

CPC classification number: C07D413/14 ,  C07D413/10 ,  C07D413/12

Abstract: The present disclosure relates to tri-substituted aryl and heteroaryl derivatives. pharmaceutical compositions containing them, and methods of using them, including methods for modulating autophagy or preventing, reversing, slowing or inhibiting the PI3K-AKT-MTOR pathway, and methods of treating diseases that are associated with autophagy or the PI3K-AKT-MTOR pathway.

公开(公告)号：US11236079B2

公开(公告)日：2022-02-01

申请号：US17046750

申请日：2019-04-09

Applicant: Neuropore Therapies, Inc.

Inventor： Emily M. Stocking ,  Wolfgang J. Wrasidlo

IPC: C07D417/12 ,  C07D417/04 ,  C07D417/10 ,  C07D285/135 ,  C07D285/08 ,  C07D277/40

Abstract: The present disclosure relates to thiazole- or diathiazole-substituted aryl and heteroaryl compounds (I), pharmaceutical compositions containing them, and methods of using them, including treatment of disorders or disease related to regulation of the Vps34/PI3K III signaling pathway.

公开(公告)号：US11708338B2

公开(公告)日：2023-07-25

申请号：US17223989

申请日：2021-04-06

Applicant: Neuropore Therapies, Inc.

Inventor： Wolfgang J. Wrasidlo ,  Emily M. Stocking ,  Srinivasa Reddy Natala ,  Diana Luz Price

IPC: C07D249/12 ,  A61P25/28 ,  A61K9/10 ,  A61P3/00 ,  C07D243/10 ,  A61K31/18

CPC classification number: C07D249/12 ,  A61K9/10 ,  A61K31/18 ,  A61P3/00 ,  A61P25/28 ,  C07D243/10

Abstract: The present disclosure relates to substituted phenyl sulfonyl phenyl triazole thiones, pharmaceutical compositions containing them, and methods of using them.

公开(公告)号：US11008294B2

公开(公告)日：2021-05-18

申请号：US16663054

申请日：2019-10-24

Applicant: Neuropore Therapies, Inc.

Inventor： Wolfgang J. Wrasidlo ,  Emily M. Stocking ,  Srinivasa Reddy Natala ,  Diana Luz Price

IPC: C07D249/12 ,  A61P25/28 ,  A61K9/10 ,  A61P3/00 ,  C07D243/10 ,  A61K31/18

Abstract: The present disclosure relates to substituted phenyl sulfonyl phenyl triazole thiones, pharmaceutical compositions containing them, and methods of using them.