公开(公告)号：US12049462B2

公开(公告)日：2024-07-30

申请号：US17982425

申请日：2022-11-07

Applicant: Neuropore Therapies, Inc.

Inventor： Emily M. Stocking ,  Wolfgang J. Wrasidlo

IPC: C07D413/14 ,  C07D413/10 ,  C07D413/12

CPC classification number: C07D413/14 ,  C07D413/10 ,  C07D413/12

Abstract: The present disclosure relates to tri-substituted aryl and heteroaryl derivatives. pharmaceutical compositions containing them, and methods of using them, including methods for modulating autophagy or preventing, reversing, slowing or inhibiting the PI3K-AKT-MTOR pathway, and methods of treating diseases that are associated with autophagy or the PI3K-AKT-MTOR pathway.

公开(公告)号：US11236079B2

公开(公告)日：2022-02-01

申请号：US17046750

申请日：2019-04-09

Applicant: Neuropore Therapies, Inc.

Inventor： Emily M. Stocking ,  Wolfgang J. Wrasidlo

IPC: C07D417/12 ,  C07D417/04 ,  C07D417/10 ,  C07D285/135 ,  C07D285/08 ,  C07D277/40

Abstract: The present disclosure relates to thiazole- or diathiazole-substituted aryl and heteroaryl compounds (I), pharmaceutical compositions containing them, and methods of using them, including treatment of disorders or disease related to regulation of the Vps34/PI3K III signaling pathway.

公开(公告)号：US20150197513A1

公开(公告)日：2015-07-16

申请号：US14420315

申请日：2013-08-08

Applicant: Neuropore Therapies, Inc.

Inventor： Wolfgang Wrasidlo ,  Emily M. Stocking

IPC: C07D417/12 ,  C07D257/06 ,  C07D277/42 ,  C07D233/88 ,  C07D207/34 ,  C07D285/135 ,  C07D271/113

CPC classification number: C07D417/12 ,  C07D207/34 ,  C07D233/88 ,  C07D233/92 ,  C07D249/14 ,  C07D257/06 ,  C07D271/113 ,  C07D277/42 ,  C07D285/135

Abstract: The present disclosure relates to certain aryl- or heteroaryl-substituted benzene derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for modulating autophagy or preventing, reversing, slowing or inhibiting the PI3K-AKT-MTOR pathway, and methods of treating diseases that are associated with autophagy or the PI3K-AKT-MTOR pathway.

Abstract translation: 本公开内容涉及某些芳基或杂芳基取代的苯衍生物，含有它们的药物组合物及其使用方法，包括调节自噬或预防，逆转，减缓或抑制PI3K-AKT-MTOR途径的方法，以及 治疗与自噬相关的疾病或PI3K-AKT-MTOR途径的疾病。

公开(公告)号：US11492348B2

公开(公告)日：2022-11-08

申请号：US17046746

申请日：2019-04-09

Applicant: Neuropore Therapies, Inc.

Inventor： Emily M. Stocking ,  Wolfgang J. Wrasidlo

IPC: C07D413/14 ,  C07D413/10 ,  C07D413/12

Abstract: The present disclosure relates to tri-substituted aryl and heteroaryl derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for modulating autophagy or preventing, reversing, slowing or inhibiting the PI3K-AKT-MTOR pathway, and methods of treating diseases that are associated with autophagy or the PI3K-AKT-MTOR pathway.

公开(公告)号：US11299487B2

公开(公告)日：2022-04-12

申请号：US16830110

申请日：2020-03-25

Applicant: Neuropore Therapies, Inc.

Inventor： Srinivasa Reddy Natala ,  Wolfgang J. Wrasidlo ,  Emily M. Stocking

IPC: C07D417/10 ,  C07C235/56 ,  C07D207/06 ,  C07D211/10 ,  C07D231/12 ,  C07D265/30 ,  C07D265/36 ,  C07D401/06 ,  C07D401/10 ,  C07D403/10 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/10 ,  C07D413/06 ,  C07D413/10 ,  C07D413/14 ,  C07D471/08 ,  C07D487/08 ,  C07D498/02

Abstract: The present disclosure relates to substituted aryl and heteroaryl compounds, pharmaceutical compositions comprising such compounds, and use of such compounds in methods of treatment or in medicaments for treatment of inflammatory diseases and certain neurological disorders that are related to inflammatory signaling processes, including but not limited to misfolded proteins.

公开(公告)号：US09738635B2

公开(公告)日：2017-08-22

申请号：US14983243

申请日：2015-12-29

Applicant: Neuropore Therapies, Inc.

Inventor： Wolfgang Wrasidlo ,  Emily M. Stocking

IPC: A61K31/535 ,  C07D417/12 ,  C07D417/14 ,  C07D403/12 ,  C07D413/12

CPC classification number: C07D417/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/14

Abstract: The present invention relates to certain heteroaryl amide compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer and melanoma.

公开(公告)号：US11708338B2

公开(公告)日：2023-07-25

申请号：US17223989

申请日：2021-04-06

Applicant: Neuropore Therapies, Inc.

Inventor： Wolfgang J. Wrasidlo ,  Emily M. Stocking ,  Srinivasa Reddy Natala ,  Diana Luz Price

IPC: C07D249/12 ,  A61P25/28 ,  A61K9/10 ,  A61P3/00 ,  C07D243/10 ,  A61K31/18

CPC classification number: C07D249/12 ,  A61K9/10 ,  A61K31/18 ,  A61P3/00 ,  A61P25/28 ,  C07D243/10

Abstract: The present disclosure relates to substituted phenyl sulfonyl phenyl triazole thiones, pharmaceutical compositions containing them, and methods of using them.

公开(公告)号：US11008294B2

公开(公告)日：2021-05-18

申请号：US16663054

申请日：2019-10-24

Applicant: Neuropore Therapies, Inc.

Inventor： Wolfgang J. Wrasidlo ,  Emily M. Stocking ,  Srinivasa Reddy Natala ,  Diana Luz Price

IPC: C07D249/12 ,  A61P25/28 ,  A61K9/10 ,  A61P3/00 ,  C07D243/10 ,  A61K31/18

Abstract: The present disclosure relates to substituted phenyl sulfonyl phenyl triazole thiones, pharmaceutical compositions containing them, and methods of using them.

公开(公告)号：US20160207912A1

公开(公告)日：2016-07-21

申请号：US14983243

申请日：2015-12-29

Applicant: Neuropore Therapies, Inc.

Inventor： Wolfgang Wrasidlo ,  Emily M. Stocking

IPC: C07D417/12 ,  C07D403/12 ,  C07D413/12

CPC classification number: C07D417/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/14

Abstract: The present invention relates to certain heteroaryl amide compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer and melanoma.

Abstract translation: 本发明涉及某些杂芳酰胺化合物，含有它们的药物组合物及其使用方法，包括预防，逆转，减缓或抑制蛋白质聚集的方法，以及治疗与蛋白质聚集有关的疾病的方法，包括神经变性疾病 如帕金森氏病，阿尔茨海默氏病，路易体病，帕金森病与痴呆，颞叶痴呆，亨廷顿氏病，肌萎缩性侧索硬化和多系统萎缩以及癌症和黑素瘤。