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1.发明公开公开(公告)号：US20240182555A1
公开(公告)日：2024-06-06
申请号：US18360143
申请日：2023-07-27
发明人： Bongcheol KIM , Dong Sik KIM , Soon-gu KWON
IPC分类号： C07K16/24
CPC分类号： C07K16/24 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要： The present disclosure relates to the pharmaceutical use of antagonists (e.g., an antibody or antigen-binding portion thereof) that specifically bind to FAM19A5 to treat a glaucoma in a subject in need thereof.
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公开(公告)号：US20210388382A1
公开(公告)日：2021-12-16
申请号：US17053733
申请日：2019-05-08
发明人： Jong-Mook KIM , Dong Sik KIM , Juwon SHIM , Soon-gu KWON
摘要： The present disclosure provides adeno-associated vims (AAV) vectors and uses thereof. In certain embodiments, the AAV vectors comprise a nucleic acid that encodes an antagonist against a family with sequence similarity 19, member A5 (FAM19A5) protein, e.g., anti-FAM19A5 antibody, e.g., anti-FAM19A5 scFv.
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3.发明公开公开(公告)号：US20230357378A1
公开(公告)日：2023-11-09
申请号：US18301803
申请日：2023-04-17
发明人： Bongcheol KIM , Dong Sik KIM , Soon-gu KWON
摘要： The present disclosure provides a method for the treatment of a neuropathic pain including a central neuropathic pain or a peripheral neuropathic pain in a subject comprising the administration of antibodies that specifically bind to human FAM19A5 and compositions comprising such antibodies. The present disclosure also provides methods for treating a neuropathic pain including a symptom of neuropathic pain, and/or an underlining cause of a neuropathic pain, by administering an antibody that specifically binds to human FAM19A5. In a specific aspect, the method comprises administering antibodies specifically bind to human FAM19A5, e.g., binds to soluble human FAM19A5 with a KD of 10 nM or less, or binds to membrane bound human FAM19A5 with a KD of 10 nM or less, or both, as measured by a method known in the art, e.g., ELISA.
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4.发明申请公开(公告)号：US20200157202A1
公开(公告)日：2020-05-21
申请号：US16626630
申请日：2018-06-27
发明人： Bongcheol KIM , Dong Sik KIM , Soon-gu KWON
IPC分类号： C07K16/24
摘要： The present disclosure relates to the pharmaceutical use of antagonists (e.g., an antibody or antigen-binding portion thereof) that specifically bind to FAM19A5 to treat a glaucoma in a subject in need thereof.
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公开(公告)号：US20240238445A1
公开(公告)日：2024-07-18
申请号：US18552290
申请日：2022-07-08
申请人： NEURACLE SCIENCE CO., LTD. , KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION , KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, SEJONG CAMPUS
发明人： Jae Young SEONG , Youngjoo BYUN , Hoyun KWAK , Sitaek OH , Min-Hyeok LEE , Yongwoo JEONG , Nui HA , Eun-Ho CHO , Suhyun LEE , Sang-Myeong LEE , Yerim LEE , Eun Bee CHO , Jae Keun LEE , Han-Byul KIM , Soon-gu KWON
IPC分类号： A61K48/00 , A61K31/055 , A61K31/085 , A61K31/136 , A61K31/137 , A61K38/08 , A61K38/10 , A61K38/17 , A61K45/06 , A61K47/64 , A61P25/02 , A61P25/28 , C12N5/0793
CPC分类号： A61K48/005 , A61K31/055 , A61K31/085 , A61K31/136 , A61K31/137 , A61K38/08 , A61K38/10 , A61K38/1709 , A61K45/06 , A61K47/64 , A61P25/02 , A61P25/28 , C12N5/0619
摘要： The present disclosure provides mimic molecules that are capable of specifically targeting a FAM19A5 protein, and thereby, inhibiting, reducing, and/or dissociating the interaction between members of the LRRC4 protein family and the FAM19A5 protein. The present disclosure also provides methods for promoting neurite outgrowth, by administering a mimic molecule described herein.
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公开(公告)号：US20230348584A1
公开(公告)日：2023-11-02
申请号：US18158259
申请日：2023-01-23
发明人： Bongcheol KIM , Eun Bee CHO , Dong Sik KIM , Jae-Keun LEE , Soon-gu KWON , Jae Young SEONG , Juwon SHIM , Tae Woo KIM , Shin-hyuk KANG
摘要： The present disclosure relates to the pharmaceutical use of antagonists (e.g., an antibody or antigen-binding portion thereof) that specifically bind to FAM19A5 to promote a blood vessel normalization and treat a disease (e.g., cancer) in a subject in need thereof, e.g., by promoting a blood vessel normalization.
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公开(公告)号：US20210347872A1
公开(公告)日：2021-11-11
申请号：US17285861
申请日：2019-10-15
发明人： Bongcheol KIM , Dong Sik KIM , Soon-gu KWON
摘要： The present disclosure relates to the pharmaceutical use of antagonists (e.g., an antibody or antigen-binding portion thereof) that specifically bind to FAM19A5 to treat a retinopathy (e.g., diabetic retinopathy) and/or maculopathy (e.g., age-related macular degeneration) in a subject in need thereof.
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公开(公告)号：US20210070849A1
公开(公告)日：2021-03-11
申请号：US17050056
申请日：2019-04-24
发明人： Bongcheol KIM , Dong Sik KIM , Soon-gu KWON
摘要： The present disclosure provides a method for the treatment of a neuropathic pain including a central neuropathic pain or a peripheral neuropathic pain in a subject comprising the administration of antibodies that specifically bind to human FAM19A5 and compositions comprising such antibodies. The present disclosure also provides methods for treating a neuropathic pain including a symptom of neuropathic pain, and/or an underlining cause of a neuropathic pain, by administering an antibody that specifically binds to human FAM19A5. In a specific aspect, the method comprises administering antibodies specifically bind to human FAM19A5, e.g., binds to soluble human FAM19A5 with a KD of 10 nM or less, or binds to membrane bound human FAM19A5 with a KD of 10 nM or less, or both, as measured by a method known in the art, e.g., ELISA.
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公开(公告)号：US20200223914A1
公开(公告)日：2020-07-16
申请号：US16626625
申请日：2018-06-27
发明人： Bongcheol KIM , Eun Bee CHO , Dong Sik KIM , Jae-Keun LEE , Soon-gu KWON , Jae Young SEONG , Juwon SHIM , Tae Woo KIM , Shin-hyuk KANG
摘要： The present disclosure relates to the pharmaceutical use of antagonists (e.g., an antibody or antigen-binding portion thereof) that specifically bind to FAM19A5 to promote a blood vessel normalization and treat a disease (e.g., cancer) in a subject in need thereof, e.g., by promoting a blood vessel normalization.
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