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公开(公告)号：US20220073601A1
公开(公告)日：2022-03-10
申请号：US17475214
申请日：2021-09-14
发明人： Bongcheol KIM , Jae-Keun LEE , Dong Sik KIM
摘要： The present disclosure relates to the pharmaceutical use of antagonists (e.g., an antibody or antigen-binding portion thereof) that specifically bind to FAM19A5 to treat or to diagnose a fibrosis and/or a fibrosis-associated disease in a subject in need thereof.
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公开(公告)号：US20230348584A1
公开(公告)日：2023-11-02
申请号：US18158259
申请日：2023-01-23
发明人： Bongcheol KIM , Eun Bee CHO , Dong Sik KIM , Jae-Keun LEE , Soon-gu KWON , Jae Young SEONG , Juwon SHIM , Tae Woo KIM , Shin-hyuk KANG
摘要： The present disclosure relates to the pharmaceutical use of antagonists (e.g., an antibody or antigen-binding portion thereof) that specifically bind to FAM19A5 to promote a blood vessel normalization and treat a disease (e.g., cancer) in a subject in need thereof, e.g., by promoting a blood vessel normalization.
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公开(公告)号：US20220064277A1
公开(公告)日：2022-03-03
申请号：US17418681
申请日：2019-12-26
发明人： Bongcheol KIM , Dong Sik KIM , Jae-Keun LEE , Juwon SHIM
摘要： The present disclosure relates to the pharmaceutical use of antagonists (e.g., an antibody or antigen-binding portion thereof) that specifically bind to FAM19A5 to treat an atherosclerosis in a subject in need thereof.
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公开(公告)号：US20200299373A1
公开(公告)日：2020-09-24
申请号：US16626624
申请日：2018-06-27
发明人： Bongcheol KIM , Jae-Keun LEE , Dong Sik KIM , Junho CHUNG , Junyeong JIN
IPC分类号： C07K16/24 , A61P35/00 , G01N33/574 , G01N33/50
摘要： The present disclosure provides antibodies that specifically bind to human FAM19A5 and compositions comprising such antibodies. Also provided herein are methods for treating fibrosis or cancer using the anti-FAM19A5 antibodies.
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公开(公告)号：US20230287096A1
公开(公告)日：2023-09-14
申请号：US18177334
申请日：2023-03-02
发明人： Bongcheol KIM , Jae-Keun LEE , Dong Sik KIM , Junho CHUNG , Junyeong JIN
IPC分类号： C07K16/24 , A61P35/00 , G01N33/50 , G01N33/574
CPC分类号： C07K16/24 , A61P35/00 , G01N33/5058 , G01N33/57407 , A61K2039/505
摘要： The present disclosure provides antibodies that specifically bind to human FAM19A5 and compositions comprising such antibodies. Also provided herein are methods for treating fibrosis or cancer using the anti-FAM19A5 antibodies.
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公开(公告)号：US20220144932A1
公开(公告)日：2022-05-12
申请号：US17290154
申请日：2019-12-31
发明人： Bongcheol KIM , Wonkyum KIM , Dong Sik KIM , Jae-Keun LEE , Jeongwon YOON , Junho CHUNG , Junyeong JIN
IPC分类号： C07K16/24
摘要： The present disclosure provides antibodies that specifically bind to human FAM19A5 and compositions comprising such antibodies. In some embodiments, antibodies are de-immunized to reduce immunogenicity in a human subject. In certain embodiments, antibodies have undergone affinity maturation. In some embodiments, the anti-FAM19A5 antibodies can modulate FAM19A5 activity, e.g, inhibit, suppress, reduce, or reverse the onset of reactive gliosis and/or excessive proliferation of reactive astrocytes, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as central nervous system damage, a degenerative brain disorder, a neuropathic pain, or a cancer, by administering an antibody that specifically binds to human FAM19A5.
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公开(公告)号：US20200223914A1
公开(公告)日：2020-07-16
申请号：US16626625
申请日：2018-06-27
发明人： Bongcheol KIM , Eun Bee CHO , Dong Sik KIM , Jae-Keun LEE , Soon-gu KWON , Jae Young SEONG , Juwon SHIM , Tae Woo KIM , Shin-hyuk KANG
摘要： The present disclosure relates to the pharmaceutical use of antagonists (e.g., an antibody or antigen-binding portion thereof) that specifically bind to FAM19A5 to promote a blood vessel normalization and treat a disease (e.g., cancer) in a subject in need thereof, e.g., by promoting a blood vessel normalization.
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