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公开(公告)号：US10995126B2
公开(公告)日：2021-05-04
申请号：US16098735
申请日：2017-05-03
发明人： Shih-Jen Liu , Hsin-Wei Chen , Steve Roffler , Ming-Hsi Huang , Chih-Hsiang Leng
摘要： Described herein are an immunogenic peptide containing the sequence of CLDSLGQWN (SEQ ID NO:2) and a method of using the peptide for treating cancer.
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公开(公告)号：US10172945B2
公开(公告)日：2019-01-08
申请号：US15547490
申请日：2016-01-12
发明人： Ming-Hsi Huang , Chiung-Yi Huang , Pele Choi-Sing Chong , Chih-Hsiang Leng , Shih-Jen Liu , Hsin-Wei Chen
IPC分类号： A61K47/34 , A61K39/39 , A61K47/06 , C08G63/672 , A61K9/113 , C08G65/332 , A61K39/00 , A61K9/00
摘要： A composition in a water-in-oil-in-water (W/O/W) emulsion is disclosed. The composition comprises: (a) a continuous aqueous phase, comprising H2O; (b) an oil phase or an oil shell, dispersed in the continuous aqueous phase; and (c) a hydrophilic polymer, stabilizing an interface between the continuous aqueous phase and the oil phase or the oil shell to form the water-in-oil-in-water (W/O/W) emulsion. The oil phase or the oil shell comprises: (i) oil; (ii) an internal aqueous phase, dispersed within the oil or the oil shell; and (iii) a lipophilic sorbitan-polyester conjugate, stabilizing an interface between the oil and the inner aqueous phase to form a water-in-oil (W/O) emulsion. The lipophilic sorbitan-polyester conjugate comprises: (1) sorbitan; and (2) poly(lactide-co-ε-caprolactone) or polylactic acid (polylactide), conjugated to the sorbitan.
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公开(公告)号：US11266728B2
公开(公告)日：2022-03-08
申请号：US16475963
申请日：2017-12-29
发明人： Hsin-Wei Chen , Chih-Hsiang Leng , Shih-Jen Liu
IPC分类号： A61K39/00 , C07K16/28 , A61K39/395 , A61K39/39 , A61K45/06 , A61K39/12 , C07K14/705
摘要： Provided is a pharmaceutical composition, including an antigen fusion protein which includes an antigen and an antagonist of an Fc gamma receptor. Also provided is a method of enhancing immunogenicity of an antigen, including conjugating the antigen with an antagonist of an Fc gamma receptor to form an antigen fusion protein. Also provided is a method of enhancing an immune response to an antigen in a subject, including administering to the subject an effective amount of an antigen fusion protein which includes an antigen and an antagonist of an Fc gamma receptor. The present invention may be applied in the development of potent vaccines based on targeting vaccine antigens to antigen-presenting cells via binding to Fc gamma receptors.
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公开(公告)号：US09415069B2
公开(公告)日：2016-08-16
申请号：US13909585
申请日：2013-06-04
IPC分类号： C12N5/00 , C12N5/02 , A61K35/15 , C12N5/0784
CPC分类号： A61K35/15 , C12N5/064 , C12N2501/052 , C12N2501/21 , C12N2501/22 , C12N2501/2304
摘要： This invention relates to an immunosuppressive cell, and methods of obtaining the cell and using the cell. The immunosuppressive cell is obtained by culturing a precursor cell in a medium that contains a GRO chemokine.
摘要翻译： 本发明涉及免疫抑制细胞，以及获得细胞和使用细胞的方法。 通过在含有GRO趋化因子的培养基中培养前体细胞获得免疫抑制细胞。
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公开(公告)号：US20140056856A1
公开(公告)日：2014-02-27
申请号：US13909585
申请日：2013-06-04
IPC分类号： A61K35/14
CPC分类号： A61K35/15 , C12N5/064 , C12N2501/052 , C12N2501/21 , C12N2501/22 , C12N2501/2304
摘要： This invention relates to an immunosuppressive cell, and methods of obtaining the cell and using the cell. The immunosuppressive cell is obtained by culturing a precursor cell in a medium that contains a GRO chemokine.
摘要翻译： 本发明涉及免疫抑制细胞，以及获得细胞和使用细胞的方法。 通过在含有GRO趋化因子的培养基中培养前体细胞获得免疫抑制细胞。
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公开(公告)号：US20190135883A1
公开(公告)日：2019-05-09
申请号：US16098735
申请日：2017-05-03
发明人： Shih-Jen Liu , Hsin-Wei Chen , Steve Roffler , Ming-Hsi Huang , Chih-Hsiang Leng
摘要： Described herein are an immunogenic peptide containing the sequence of CLDSLGQWN (SEQ ID NO:2) and a method of using the peptide for treating cancer.
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