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公开(公告)号：US09415069B2
公开(公告)日：2016-08-16
申请号：US13909585
申请日：2013-06-04
IPC分类号： C12N5/00 , C12N5/02 , A61K35/15 , C12N5/0784
CPC分类号： A61K35/15 , C12N5/064 , C12N2501/052 , C12N2501/21 , C12N2501/22 , C12N2501/2304
摘要： This invention relates to an immunosuppressive cell, and methods of obtaining the cell and using the cell. The immunosuppressive cell is obtained by culturing a precursor cell in a medium that contains a GRO chemokine.
摘要翻译： 本发明涉及免疫抑制细胞，以及获得细胞和使用细胞的方法。 通过在含有GRO趋化因子的培养基中培养前体细胞获得免疫抑制细胞。
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公开(公告)号：US10172945B2
公开(公告)日：2019-01-08
申请号：US15547490
申请日：2016-01-12
发明人： Ming-Hsi Huang , Chiung-Yi Huang , Pele Choi-Sing Chong , Chih-Hsiang Leng , Shih-Jen Liu , Hsin-Wei Chen
IPC分类号： A61K47/34 , A61K39/39 , A61K47/06 , C08G63/672 , A61K9/113 , C08G65/332 , A61K39/00 , A61K9/00
摘要： A composition in a water-in-oil-in-water (W/O/W) emulsion is disclosed. The composition comprises: (a) a continuous aqueous phase, comprising H2O; (b) an oil phase or an oil shell, dispersed in the continuous aqueous phase; and (c) a hydrophilic polymer, stabilizing an interface between the continuous aqueous phase and the oil phase or the oil shell to form the water-in-oil-in-water (W/O/W) emulsion. The oil phase or the oil shell comprises: (i) oil; (ii) an internal aqueous phase, dispersed within the oil or the oil shell; and (iii) a lipophilic sorbitan-polyester conjugate, stabilizing an interface between the oil and the inner aqueous phase to form a water-in-oil (W/O) emulsion. The lipophilic sorbitan-polyester conjugate comprises: (1) sorbitan; and (2) poly(lactide-co-ε-caprolactone) or polylactic acid (polylactide), conjugated to the sorbitan.
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公开(公告)号：US20170056491A1
公开(公告)日：2017-03-02
申请号：US15307926
申请日：2015-03-26
IPC分类号： A61K39/125
CPC分类号： A61K39/125 , A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/542 , A61K2039/545 , A61K2039/55566 , A61K2039/57 , C12N2710/10323 , C12N2710/10343 , C12N2770/32323 , C12N2770/32334 , C12N2770/32351 , C12N2770/32371 , Y02A50/466
摘要： The present invention relates to a recombinant adenoviral vector for generating immunity against enterovirus infection. In one embodiment, the recombinant adenoviral vector of the invention comprises an expression cassette encoding a PI protein and a 3 CD protease of an enterovirus. In another embodiment, the recombinant adenoviral vector of the invention comprises an expression cassette encoding a 3C protease or a 3CD protease of an enterovirus. The present invention also relates to a vaccine composition comprising the recombinant adenoviral vector as described. A method of inducing an immune response in a subject against enterovirus infection using the recombinant adenoviral vector and the vaccine composition is provided. Further provided is a method for producing virus like particles of an enterovirus by expressing the adenoviral vector as described herein in mammalian cells.
摘要翻译： 本发明涉及用于产生针对肠道病毒感染的免疫的重组腺病毒载体。 在一个实施方案中，本发明的重组腺病毒载体包含编码肠道病毒的PI蛋白和3CD蛋白酶的表达盒。 在另一个实施方案中，本发明的重组腺病毒载体包含编码肠病毒的3C蛋白酶或3CD蛋白酶的表达盒。 本发明还涉及包含如上所述的重组腺病毒载体的疫苗组合物。 提供了使用重组腺病毒载体和疫苗组合物诱导受试者免疫应答的方法。 还提供了通过在哺乳动物细胞中表达本文所述的腺病毒载体来产生病毒样肠道病毒颗粒的方法。
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4.发明授权Compositions and methods for treating clostridium difficile-associated diseases 有权治疗艰难梭菌相关疾病的组合物和方法公开(公告)号：US09493518B2
公开(公告)日：2016-11-15
申请号：US14209987
申请日：2014-03-13
CPC分类号： C07K14/33 , A61K39/08 , A61K39/39 , A61K2039/543 , A61K2039/55544 , A61K2039/55566 , C07K2319/40 , C12N2799/026 , G01N33/56911 , G01N2333/33
摘要： Described herein are isolated polypeptides each containing one or more receptor-binding sites of toxin A (tcdA) of Clostridium difficile (Cd), nucleic acids encoding the polypeptides, and methods of using the polypeptides and nucleic acids.
摘要翻译： 本文描述了各自含有一种或多种艰难梭菌（Cd）的毒素A（tcdA）的受体结合位点，编码多肽的核酸和使用多肽和核酸的方法的分离的多肽。
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5.发明申请COMPOSITIONS AND METHODS FOR TREATING CLOSTRIDIUM DIFFICILE-ASSOCIATED DISEASES 审中-公开治疗闭锁性相关疾病的组合物和方法公开(公告)号：US20140271700A1
公开(公告)日：2014-09-18
申请号：US14209987
申请日：2014-03-13
IPC分类号： C07K14/33 , A61K39/39 , G01N33/569
CPC分类号： C07K14/33 , A61K39/08 , A61K39/39 , A61K2039/543 , A61K2039/55544 , A61K2039/55566 , C07K2319/40 , C12N2799/026 , G01N33/56911 , G01N2333/33
摘要： Described herein are isolated polypeptides each containing one or more receptor-binding sites of toxin A (tcdA) of Clostridium difficile (Cd), nucleic acids encoding the polypeptides, and methods of using the polypeptides and nucleic acids.
摘要翻译： 本文描述了各自含有一种或多种艰难梭菌（Cd）的毒素A（tcdA）的受体结合位点，编码多肽的核酸和使用多肽和核酸的方法的分离的多肽。
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公开(公告)号：US10004796B2
公开(公告)日：2018-06-26
申请号：US15307926
申请日：2015-03-26
IPC分类号： A61K48/00 , C12N15/861 , C12N15/00 , A61K38/00 , C12N15/63 , A61K39/125 , A61K39/12 , A61K39/00
CPC分类号： A61K39/125 , A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/542 , A61K2039/545 , A61K2039/55566 , A61K2039/57 , C12N2710/10323 , C12N2710/10343 , C12N2770/32323 , C12N2770/32334 , C12N2770/32351 , C12N2770/32371 , Y02A50/466
摘要： The present invention relates to a recombinant adenoviral vector for generating immunity against enterovirus infection. In one embodiment, the recombinant adenoviral vector of the invention comprises an expression cassette encoding a PI protein and a 3 CD protease of an enterovirus. In another embodiment, the recombinant adenoviral vector of the invention comprises an expression cassette encoding a 3C protease or a 3CD protease of an enterovirus. The present invention also relates to a vaccine composition comprising the recombinant adenoviral vector as described. A method of inducing an immune response in a subject against enterovirus infection using the recombinant adenoviral vector and the vaccine composition is provided. Further provided is a method for producing virus like particles of an enterovirus by expressing the adenoviral vector as described herein in mammalian cells.
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