公开(公告)号：US10517075B2

公开(公告)日：2019-12-24

申请号：US15905203

申请日：2018-02-26

Applicant: Nanyang Technological University

Inventor： Nguan Soon Tan ,  Han Chung Kelvin Chong

IPC: A61K38/00 ,  H04W72/04 ,  C07K14/515 ,  A61K38/16 ,  A61K38/17 ,  A61K38/10 ,  G01N33/68 ,  H04L5/00

Abstract: A method and a pharmaceutical composition for increasing wound healing in an individual in need thereof, the method comprising administering an angiopoietin like 4 (ANGPTL4) polypeptide or a therapeutically active fragment thereof.

公开(公告)号：US20150210758A1

公开(公告)日：2015-07-30

申请号：US14421772

申请日：2013-08-06

Applicant: NANYANG TECHNOLOGICAL UNIVERSITY

Inventor： Julien Lescar ,  Yee Hwa Wong ,  Wei Min Edmond Chua ,  Nguan Soon Andrew Tan ,  Han Chung Kelvin Chong ,  Ming Jie Tan ,  Royston-Luke Huang

IPC: C07K16/18 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/18 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/622 ,  C07K2317/76

Abstract: An antibody that binds C terminal region of angiopoietin like 4 protein its use and methods of treating cancer with the same.

Abstract translation: 一种抗体，其结合血管生成素的C端区，如4蛋白，其用途和治疗癌症的方法相同。

公开(公告)号：US09931371B2

公开(公告)日：2018-04-03

申请号：US14415399

申请日：2013-07-03

Applicant: Nanyang Technological University

Inventor： Nguan Soon Tan ,  Han Chung Kelvin Chong

IPC: A61K38/00 ,  A61K38/10 ,  C07K14/515 ,  A61K38/16 ,  A61K38/17 ,  G01N33/68

CPC classification number: H04W72/0406 ,  A61K38/10 ,  A61K38/16 ,  A61K38/1709 ,  C07K14/515 ,  G01N33/6893 ,  G01N2333/515 ,  H04L5/0007 ,  H04L5/0053 ,  H04L5/006

Abstract: A method and a pharmaceutical composition for increasing wound healing in an individual in need thereof, the method comprising administering an angiopoietin like 4 (ANGPTL4) polypeptide or a therapeutically active fragment thereof.

公开(公告)号：US10160803B2

公开(公告)日：2018-12-25

申请号：US14763423

申请日：2014-01-23

Applicant: National University of Singapore ,  Nanyang Technological University

Inventor： Vincent Tak Kwong Chow ,  Nguan Soon Tan ,  Liang Li ,  Ming Jie Tan ,  Han Chung Kelvin Chong

IPC: G01N33/53 ,  A61K39/395 ,  A61K45/00 ,  C07K16/22 ,  G01N33/569 ,  G01N33/68 ,  C12Q1/6883 ,  A61K49/00 ,  G01N33/74 ,  G06F19/12 ,  A61K39/00

Abstract: The invention relates to the C-terminal fragment of angiopoietin-related protein 4 [cAngptl4] as a diagnostic marker for viral and bacterial pneumonia; anti-angiopoietin-related protein 4 therapeutic antibodies, and the use of anti-angiopoietin-related protein 4 antibodies in the treatment of viral and bacterial pneumonia.

公开(公告)号：US20150196616A1

公开(公告)日：2015-07-16

申请号：US14415399

申请日：2013-07-03

Applicant: Nanyang Technological University

Inventor： Nguan Soon Tan ,  Han Chung Kelvin Chong

IPC: A61K38/10 ,  G01N33/68

CPC classification number: H04W72/0406 ,  A61K38/10 ,  A61K38/16 ,  A61K38/1709 ,  C07K14/515 ,  G01N33/6893 ,  G01N2333/515 ,  H04L5/0007 ,  H04L5/0053 ,  H04L5/006

Abstract: A method and a pharmaceutical composition for increasing wound healing in an individual in need thereof, the method comprising administering an angiopoietin like 4 (ANGPTL4) polypeptide or a therapeutically active fragment thereof.

Abstract translation: 一种用于在有需要的个体中增加伤口愈合的方法和药物组合物，所述方法包括给予像4（ANGPTL4）多肽或其治疗活性片段的血管生成素。

公开(公告)号：US20180199327A1

公开(公告)日：2018-07-12

申请号：US15905203

申请日：2018-02-26

Applicant: Nanyang Technological University

Inventor： Nguan Soon Tan ,  Han Chung Kelvin Chong

IPC: H04W72/04

CPC classification number: H04W72/0406 ,  A61K38/10 ,  A61K38/16 ,  A61K38/1709 ,  C07K14/515 ,  G01N33/6893 ,  G01N2333/515 ,  H04L5/0007 ,  H04L5/0053 ,  H04L5/006

Abstract: A method and a pharmaceutical composition for increasing wound healing in an individual in need thereof, the method comprising administering an angiopoietin like 4 (ANGPTL4) polypeptide or a therapeutically active fragment thereof.

公开(公告)号：US20150368331A1

公开(公告)日：2015-12-24

申请号：US14763423

申请日：2014-01-23

Applicant: National University of Singapore ,  Nanyang Technological University

Inventor： Vincent Tak Kwong Chow ,  Nguan Soon Tan ,  Liang Li ,  Ming Jie Tan ,  Han Chung Kelvin Chong

IPC: C07K16/22 ,  G06F19/12 ,  A61K49/00 ,  C12Q1/68 ,  G01N33/74

CPC classification number: C07K16/22 ,  A61K49/0008 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/56911 ,  G01N33/68 ,  G01N33/74 ,  G01N2333/515 ,  G01N2500/04 ,  G01N2500/20 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/70 ,  G01N2800/7095 ,  G06F19/12

Abstract: The invention relates to the C-terminal fragment of angiopoietin-related protein 4 [cAngptl4] as a diagnostic marker for viral and bacterial pneumonia; anti-angiopoietin-related protein 4 therapeutic antibodies, and the use of anti-angiopoietin-related protein 4 antibodies in the treatment of viral and bacterial pneumonia.

Abstract translation: 本发明涉及作为病毒和细菌性肺炎诊断标志物的血管生成素相关蛋白4 [cAngpt14]的C-末端片段; 抗血管生成素相关蛋白4治疗性抗体，以及使用抗血管生成素相关蛋白4抗体治疗病毒性和细菌性肺炎。