公开(公告)号：US20240241195A1

公开(公告)日：2024-07-18

申请号：US18582293

申请日：2024-02-20

Applicant: NVISION IMAGING TECHNOLOGIES GMBH ,  UNIVERSITÄT ULM

Inventor： Ilai SCHWARTZ ,  Michael KEIM ,  Martin PLENIO ,  Benedikt TRATZMILLER

IPC: G01R33/28 ,  A61K49/10 ,  C07C67/14 ,  C07C67/293 ,  C07C69/716 ,  C07F7/08 ,  G01R33/46 ,  G01R33/44

CPC classification number: G01R33/282 ,  A61K49/10 ,  C07C67/14 ,  C07C67/293 ,  C07C69/716 ,  C07F7/081 ,  C07F7/083 ,  G01R33/4608 ,  C07B2200/05 ,  G01R33/445

Abstract: A method for preparing an NMR material, comprising generating parahydrogen in gas or liquid form at a first location; transporting the parahydrogen away from the first location; mixing a precursor compound including a metabolite component with a catalyst for hydrogenation; hydrogenating the precursor compound using the parahydrogen; transferring polarization in the precursor compound to a nuclear spin of the metabolite component; cleaving a side arm of the precursor compound in a chemical reaction, with the metabolite molecule being one of the products of the reaction; separating the metabolite molecule from the catalyst for hydrogenation and other products of the reaction; and generating metabolite molecules for use in an MRI scanner by extracting a sample of the metabolite molecule having at least 5% polarization.

公开(公告)号：US20240272252A1

公开(公告)日：2024-08-15

申请号：US18256202

申请日：2021-12-07

Applicant: NVISION IMAGING TECHNOLOGIES GMBH

Inventor： Ilai SCHWARTZ ,  Michael KEIM ,  Stephan KNECHT

IPC: G01R33/28 ,  G01R33/30 ,  G01R33/31 ,  G01R33/42 ,  G01R33/465

CPC classification number: G01R33/282 ,  G01R33/307 ,  G01R33/31 ,  G01R33/42 ,  G01R33/465

Abstract: Systems and methods are disclosed for increasing a nuclear spin polarization in a target compound. Nuclear spin polarization can be increased by obtaining the target compound or a precursor of the target compound. The target compound or precursor can include a first proton and a second proton sharing a singlet spin order and a third proton coupled at least to one of the first proton or the second proton. A target atom can be coupled to at least the third proton. The precursor can be placed within a mean magnetic field strength below 500 mT. A magnetic resonance (MR) pulse sequence can be applied to the precursor. the MR pulse sequence configured to transfer population from the first and second protons to the target atom, thereby imparting a non-equilibrium nuclear spin polarization of at least 1 %, 2%, 5%, 10%, or 20% to the target atom.

公开(公告)号：US20240018087A1

公开(公告)日：2024-01-18

申请号：US18473243

申请日：2023-09-23

Applicant: NVISION IMAGING TECHNOLOGIES GMBH

Inventor： Ilai SCHWARTZ ,  Michael KEIM ,  Stephan KNECHT

IPC: C07C69/732 ,  C07C67/40 ,  C07B59/00

CPC classification number: C07C69/732 ,  C07C67/40 ,  C07B59/001 ,  C07B2200/05

Abstract: The present disclosure describes hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications. The present disclosure describes methods for producing hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications. The present disclosure describes precursor compounds for use in producing hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications.

公开(公告)号：US20240299593A1

公开(公告)日：2024-09-12

申请号：US18573662

申请日：2022-06-22

Applicant: NVISION IMAGING TECHNOLOGIES GMBH

Inventor： Ilai SCHWARTZ ,  Michael KEIM ,  Stephan KNECHT ,  Christophoros VASSILIOU ,  Felix JOSTEN ,  Senay KARAALI

IPC: A61K49/06 ,  A61K9/08 ,  B01J19/08 ,  G01R33/28

CPC classification number: A61K49/06 ,  A61K9/08 ,  B01J19/087 ,  G01R33/282 ,  B01J2219/085

Abstract: The present disclosure describes hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications. The present disclosure describes methods for producing hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications. The present disclosure describes precursor compounds for use in producing hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications.

公开(公告)号：US20230152399A1

公开(公告)日：2023-05-18

申请号：US17995232

申请日：2021-03-31

Applicant: Martin PLENIO ,  Benedikt TRATZMILLER ,  NVISION IMAGING TECHNOLOGIES GMBH

Inventor： Ilai SCHWARTZ ,  Michael KEIM ,  Martin PLENIO ,  Benedikt TRATZMILLER

IPC: G01R33/28 ,  A61K49/10 ,  C07C69/716 ,  C07F7/08 ,  C07C67/293 ,  C07C67/14 ,  G01R33/46

CPC classification number: G01R33/282 ,  A61K49/10 ,  C07C69/716 ,  C07F7/081 ,  C07F7/083 ,  C07C67/293 ,  C07C67/14 ,  G01R33/4608 ,  C07B2200/05

Abstract: A method for preparing an NMR material, comprising generating parahydrogen in gas or liquid form at a first location; transporting the parahydrogen away from the first location; mixing a precursor compound including a metabolite component with a catalyst for hydrogenation; hydrogenating the precursor compound using the parahydrogen; transferring polarization in the precursor compound to a nuclear spin of the metabolite component; cleaving a side arm of the precursor compound in a chemical reaction, with the metabolite molecule being one of the products of the reaction; separating the metabolite molecule from the catalyst for hydrogenation and other products of the reaction; and generating metabolite molecules for use in an MRI scanner by extracting a sample of the metabolite molecule having at least 5% polarization.

公开(公告)号：US20240350678A1

公开(公告)日：2024-10-24

申请号：US18687044

申请日：2022-08-26

Applicant: NVISION IMAGING TECHNOLOGIES GMBH

Inventor： Ilai SCHWARTZ ,  Michael KEIM ,  Stephan KNECHT

IPC: A61K49/10 ,  C07B59/00

CPC classification number: A61K49/10 ,  C07B59/001 ,  C07B2200/05

Abstract: The present disclosure describes hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications. The present disclosure describes methods for producing hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications. The present disclosure describes precursor compounds for use in producing hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications.

公开(公告)号：US20230295058A1

公开(公告)日：2023-09-21

申请号：US18006497

申请日：2021-07-23

Applicant: NVISION IMAGING TECHNOLOGIES GMBH

Inventor： Ilai SCHWARTZ ,  Michael KEIM

IPC: C07B59/00 ,  C07D213/16 ,  B01J19/08 ,  C07C67/08 ,  C07C67/283 ,  C07C51/347 ,  G01R33/28 ,  G01R33/30

CPC classification number: C07B59/002 ,  C07D213/16 ,  B01J19/088 ,  C07C67/08 ,  C07C67/283 ,  C07C51/347 ,  G01R33/282 ,  G01R33/30 ,  B01J2219/0805 ,  C07B2200/05

Abstract: Systems and methods are disclosed for generation of hyperpolarized target compounds. Generation of a hyperpolarized target compound can include application of a sequence of microwave pulses to a solution containing the target compound or a precursor of the target compound; or modulation of a magnetic field applied to the solution. When the precursor is hyperpolarized, the precursor can be cleaved to generate the hyperpolarized target compound. The hyperpolarized target compound can then be induced to precipitate out of the solution. The precipitate can be redissolved in a specified volume of solvent to form a solution having a desired concentration of the hyperpolarized target compound.

公开(公告)号：US20220018915A1

公开(公告)日：2022-01-20

申请号：US17309345

申请日：2019-11-20

Applicant: Nvision Imaging Technologies GmbH

Inventor： Ilai SCHWARTZ ,  Tim Rolf EICHHORN ,  Christophoros VASSILIOU ,  Michael KEIM

IPC: G01R33/28 ,  G01N24/08

Abstract: Systems and methods for generating hyperpolarized target materials are disclosed. The disclosed systems and methods can include hyperpolarizing a compound then transferring polarization to a target material. The compound can be selected to have nuclear spins. The compound can be further selected to have electron spins that, when exposed to certain electromagnetic radiation, exceed a predetermined level of polarization. The compound can be exposed to such electromagnetic radiation, optically hyperpolarizing the electron spins of the compound. Polarization can then be transferred from the electron spins of the compound to nuclear spins of the compound, at least in part by exposing the compound to a magnetic field. The compound can be exposed to the target material before or after pulverizing the compound to increase the surface area of the compound, thereby facilitating transfer of polarization from the compound to the target material.