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公开(公告)号：US11352406B2
公开(公告)日：2022-06-07
申请号：US15754395
申请日：2016-08-24
申请人： Novo Nordisk A/S
发明人： Peter Madsen , Anthony Murray , Martin Muenzel , Claudia Ulrich Hjoerringgaard , Susanne Hostrup , Tine Glendorf , Mathias Norrman , Christian Fledelius
摘要： The present invention is in the therapeutic fields of drugs for medical conditions relating to diabetes. More specifically the invention relates to novel acylated derivatives of human insulin analogues. The invention also provides pharmaceutical compositions comprising such insulin derivatives, and relates to the use of such derivatives for the treatment or prevention of medical conditions relating to diabetes.
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公开(公告)号：US20180244743A1
公开(公告)日：2018-08-30
申请号：US15754342
申请日：2016-08-24
申请人： Novo Nordisk A/S
发明人： Peter Madsen , Claudia Ulrich Hjoerringgaard , Martin Muenzel , Susanne Hostrup , Christian Fledelius
摘要： The present invention is in the therapeutic fields of drugs for medical conditions relating to diabetes. More specifically the invention relates to novel acylated derivatives of human insulin analogues. The invention also provides pharmaceutical compositions comprising such insulin derivatives, and relates to the use of such derivatives for the treatment or prevention of medical conditions relating to diabetes.
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公开(公告)号：US09896496B2
公开(公告)日：2018-02-20
申请号：US15023872
申请日：2014-10-03
申请人： Novo Nordisk A/S
摘要： The present invention provides a novel derivative of an analogue of human insulin, useful for the treatment of diabetes.
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公开(公告)号：US20150210747A1
公开(公告)日：2015-07-30
申请号：US14684863
申请日：2015-04-13
申请人： NOVO NORDISK A/S
发明人： Peter Madsen , Thomas B. Kjeldsen , Thomas Hoeg-Jensen , Palle Jakobsen , Tina Moeller Tagmose , Tine Glendorf , Janos Tibor Kodra , Patrick William Garibay , Jacob Sten Petersen
IPC分类号： C07K14/62
摘要： Novel acylated insulin analogues exhibiting resistance towards proteases can, effectively, be administered pulmonary or orally. The insulin analogues contain B25H and A14E or A14H.
摘要翻译： 对蛋白酶具有抗性的新型酰化胰岛素类似物可以有效地被肺或口服给药。 胰岛素类似物含有B25H和A14E或A14H。
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公开(公告)号：US20140357838A1
公开(公告)日：2014-12-04
申请号：US14366987
申请日：2012-12-21
申请人： Novo Nordisk A/S
IPC分类号： C07K14/62
CPC分类号： C07K14/62 , A61K38/00 , A61K38/28 , A61K47/542 , A61K47/543 , A61K47/544 , C07K1/1077
摘要： The invention is related to novel N-terminally modified insulin derivatives comprising extra disulphide bond(s), pharmaceutical compositions comprising such and methods of making such.
摘要翻译： 本发明涉及包含额外的二硫键的新型N末端修饰的胰岛素衍生物，包含这些二硫键的药物组合物及其制备方法。
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公开(公告)号：US20230192801A1
公开(公告)日：2023-06-22
申请号：US17961438
申请日：2022-10-06
申请人： Novo Nordisk A/S
发明人： Frantisek Hubalek , Mathias Norrman , Helle Birk Olsen , Peter Madsen , Thomas Boerglum Kjeldsen , Jeppe Sturis
摘要： The present invention is in the therapeutic field of drugs for medical conditions relating to diabetes. More specifically the invention relates to insulin analogues of human insulin. The invention provides pharmaceutical compositions comprising such insulin analogues and the uses if the such analogues for the treatment or prevention of medical conditions relating to diabetes.
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公开(公告)号：US20220009989A1
公开(公告)日：2022-01-13
申请号：US17281813
申请日：2019-10-04
申请人： Novo Nordisk A/S
发明人： Martin Werner Borchsenius Muenzel , Susanne Hostrup , Gro Klitgaard Povlsen , Mathias Norrman , Thomas Boerglum Kjeldsen , Claudia Ulrich Hjoerringgaard , Peter Madsen
IPC分类号： C07K14/62 , C07K14/485
摘要： The present invention relates to novel covalently linked bi-functional fusion proteins comprising insulin and EGF(A) analogues or derivatives thereof, and their pharmaceutical use. Furthermore, the invention relates to pharmaceutical compositions comprising such bi-functional compounds, and to the use of such compounds for the treatment or prevention of medical conditions relating to diabetes and dyslipidaemia associated with diabetes.
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公开(公告)号：US10259856B2
公开(公告)日：2019-04-16
申请号：US14686176
申请日：2015-04-14
申请人： Novo Nordisk A/S
发明人： Peter Madsen , Thomas Boerglum Kjeldsen , Thomas Hoeg-Jensen , Palle Jakobsen , Tina Moeller Tagmose , Tine Glendorf , Janos Tibor Kodra , Patrick William Garibay , Jacob Sten Petersen
摘要： Novel acylated insulin analogues exhibiting resistance towards proteases can, effectively, be administered pulmonary or orally. The insulin analogues contain B25H and A14E or A14H.
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公开(公告)号：US20180305431A1
公开(公告)日：2018-10-25
申请号：US15754395
申请日：2016-08-24
申请人： Novo Nordisk A/S
发明人： Peter Madsen , Anthony Murray , Martin Muenzel , Claudia Ulrich Hjoerringgaard , Susanne Hostrup , Tine Glendorf , Mathias Norrman , Christian Fledelius
摘要： The present invention is in the therapeutic fields of drugs for medical conditions relating to diabetes. More specifically the invention relates to novel acylated derivatives of human insulin analogues. The invention also provides pharmaceutical compositions comprising such insulin derivatives, and relates to the use of such derivatives for the treatment or prevention of medical conditions relating to diabetes.
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10.发明申请公开(公告)号：US20180000742A1
公开(公告)日：2018-01-04
申请号：US15546299
申请日：2015-01-29
申请人： Novo Nordisk A/S
发明人： Lars Hovgaard , Hanne Refsgaard , Thomas Boerglum Kjeldsen , Peter Madsen , Giustino Di Pretoro
CPC分类号： A61K9/5026 , A61K9/0053 , A61K9/1617 , A61K9/2013 , A61K9/2018 , A61K9/5089 , A61K38/28 , A61K47/12
摘要： The present invention relates to a solid oral insulin composition comprising a salt of capric acid which enhances the bioavailability and/or the absorption of said acylated insulin in combination with a polyvinyl alcohol coating, which is soluble in aqueous media independent of pH.
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