公开(公告)号：US11352406B2

公开(公告)日：2022-06-07

申请号：US15754395

申请日：2016-08-24

申请人： Novo Nordisk A/S

发明人： Peter Madsen ,  Anthony Murray ,  Martin Muenzel ,  Claudia Ulrich Hjoerringgaard ,  Susanne Hostrup ,  Tine Glendorf ,  Mathias Norrman ,  Christian Fledelius

IPC分类号： C07K14/62 ,  A61K47/22 ,  A61K38/00

摘要： The present invention is in the therapeutic fields of drugs for medical conditions relating to diabetes. More specifically the invention relates to novel acylated derivatives of human insulin analogues. The invention also provides pharmaceutical compositions comprising such insulin derivatives, and relates to the use of such derivatives for the treatment or prevention of medical conditions relating to diabetes.

公开(公告)号：US20190183979A1

公开(公告)日：2019-06-20

申请号：US16280603

申请日：2019-02-20

申请人： Novo Nordisk A/S

发明人： Mathias Norrman ,  Susanne Hostrup ,  Dorte Bjerre Steensgaard ,  Holger Martin Strauss ,  Rosa Rebecca Erritzoee Hansen ,  Svend Havelund ,  Morten Schlein ,  Jesper Soendergaard Pedersen

IPC分类号： A61K38/28 ,  A61K47/02 ,  A61K47/10 ,  A61P5/48

摘要： The present invention is in the field of pharmaceutical compositions for the treatment of medical conditions relating to diabetes. More specifically the invention provides pharmaceutical compositions comprising a long-acting acylated derivative of a human insulin analogue, and to the medical use of such compositions for basal insulin administration therapy.

公开(公告)号：US11649269B2

公开(公告)日：2023-05-16

申请号：US17281813

申请日：2019-10-04

申请人： Novo Nordisk A/S

发明人： Martin Werner Borchsenius Muenzel ,  Susanne Hostrup ,  Gro Klitgaard Povlsen ,  Mathias Norrman ,  Thomas Boerglum Kjeldsen ,  Claudia Ulrich Hjoerringgaard ,  Peter Madsen

IPC分类号： A61K38/00 ,  C07K14/62 ,  C07K14/485

CPC分类号： C07K14/62 ,  C07K14/485 ,  A61K38/00

摘要： The present invention relates to novel covalently linked bi-functional fusion proteins comprising insulin and EGF(A) analogues or derivatives thereof, and their pharmaceutical use. Furthermore, the invention relates to pharmaceutical compositions comprising such bi-functional compounds, and to the use of such compounds for the treatment or prevention of medical conditions relating to diabetes and dyslipidaemia associated with diabetes.

公开(公告)号：US10596231B2

公开(公告)日：2020-03-24

申请号：US16280603

申请日：2019-02-20

申请人： Novo Nordisk A/S

发明人： Mathias Norrman ,  Susanne Hostrup ,  Dorte Bjerre Steensgaard ,  Holger Martin Strauss ,  Rosa Rebecca Erritzoee Hansen ,  Svend Havelund ,  Morten Schlein ,  Jesper Soendergaard Pedersen

IPC分类号： A61K38/28 ,  A61P5/48 ,  A61K47/02 ,  A61K47/10

摘要： The present invention is in the field of pharmaceutical compositions for the treatment of medical conditions relating to diabetes. More specifically the invention provides pharmaceutical compositions comprising a long-acting acylated derivative of a human insulin analogue, and to the medical use of such compositions for basal insulin administration therapy.

公开(公告)号：US20240141011A1

公开(公告)日：2024-05-02

申请号：US18541682

申请日：2023-12-15

申请人： Novo Nordisk A/S

发明人： Frantisek Hubalek ,  Mathias Norrman ,  Helle Birk Olsen ,  Peter Madsen ,  Thomas Boerglum Kjeldsen ,  Jeppe Sturis

IPC分类号： C07K14/62 ,  A61K47/22 ,  A61P3/10

CPC分类号： C07K14/62 ,  A61K47/22 ,  A61P3/10

摘要： The present invention is in the therapeutic field of drugs for medical conditions relating to diabetes. More specifically the invention relates to insulin analogues of human insulin. The invention provides pharmaceutical compositions comprising such insulin analogues and the uses if the such analogues for the treatment or prevention of medical conditions relating to diabetes.

公开(公告)号：US20220202909A1

公开(公告)日：2022-06-30

申请号：US17692238

申请日：2022-03-11

申请人： Novo Nordisk A/S

发明人： Mathias Norrman ,  Susanne Hostrup ,  Dorte Bjerre Steensgaard ,  Holger Martin Strauss ,  Rosa Rebecca Erritzoee Hansen ,  Svend Havelund ,  Morten Schlein ,  Jesper Soendergaard Pedersen

IPC分类号： A61K38/28 ,  A61P5/48 ,  A61K47/02 ,  A61K47/10

摘要： The present invention is in the field of pharmaceutical compositions for the treatment of medical conditions relating to diabetes. More specifically the invention provides pharmaceutical compositions comprising a long-acting acylated derivative of a human insulin analogue, and to the medical use of such compositions for basal insulin administration therapy.

公开(公告)号：US20210179685A1

公开(公告)日：2021-06-17

申请号：US17117263

申请日：2020-12-10

申请人： Novo Nordisk A/S

发明人： Frantisek Hubalek ,  Mathias Norrman ,  Helle Birk Olsen ,  Peter Madsen ,  Thomas Boerglum Kjeldsen

IPC分类号： C07K14/62 ,  A61K47/22 ,  A61P3/10

摘要： The present invention is in the therapeutic field of drugs for medical conditions relating to diabetes. More specifically the invention relates to insulin analogues of human insulin. The invention provides pharmaceutical compositions comprising such insulin analogues and the uses if the such analogues for the treatment or prevention of medical conditions relating to diabetes.

公开(公告)号：US20200283493A1

公开(公告)日：2020-09-10

申请号：US16829769

申请日：2020-03-25

申请人： Novo Nordisk A/S

发明人： Peter Madsen ,  Martin Muenzel ,  Claudia Ulrich Hjoerringgaard ,  Susanne Hostrup ,  Tine Glendorf ,  Mathias Norrman ,  Christian Fledelius

IPC分类号： C07K14/62 ,  A61P3/10 ,  A61K31/4406 ,  A61K38/28

摘要： The present invention is in the therapeutic fields of drugs for medical conditions relating to diabetes. More specifically the invention relates to novel acylated derivatives of human insulin analogues. The invention also provides pharmaceutical compositions comprising such insulin derivatives, and relates to the use of such derivatives for the treatment or prevention of medical conditions relating to diabetes.

公开(公告)号：US20230192801A1

公开(公告)日：2023-06-22

申请号：US17961438

申请日：2022-10-06

申请人： Novo Nordisk A/S

发明人： Frantisek Hubalek ,  Mathias Norrman ,  Helle Birk Olsen ,  Peter Madsen ,  Thomas Boerglum Kjeldsen ,  Jeppe Sturis

IPC分类号： C07K14/62 ,  A61P3/10 ,  A61K47/22

CPC分类号： C07K14/62 ,  A61P3/10 ,  A61K47/22

摘要： The present invention is in the therapeutic field of drugs for medical conditions relating to diabetes. More specifically the invention relates to insulin analogues of human insulin. The invention provides pharmaceutical compositions comprising such insulin analogues and the uses if the such analogues for the treatment or prevention of medical conditions relating to diabetes.

公开(公告)号：US20220009989A1

公开(公告)日：2022-01-13

申请号：US17281813

申请日：2019-10-04

申请人： Novo Nordisk A/S

发明人： Martin Werner Borchsenius Muenzel ,  Susanne Hostrup ,  Gro Klitgaard Povlsen ,  Mathias Norrman ,  Thomas Boerglum Kjeldsen ,  Claudia Ulrich Hjoerringgaard ,  Peter Madsen

IPC分类号： C07K14/62 ,  C07K14/485

摘要： The present invention relates to novel covalently linked bi-functional fusion proteins comprising insulin and EGF(A) analogues or derivatives thereof, and their pharmaceutical use. Furthermore, the invention relates to pharmaceutical compositions comprising such bi-functional compounds, and to the use of such compounds for the treatment or prevention of medical conditions relating to diabetes and dyslipidaemia associated with diabetes.