公开(公告)号：US11453677B2

公开(公告)日：2022-09-27

申请号：US16933000

申请日：2020-07-20

申请人： Novartis AG

发明人： Rama Jain ,  Dennis Christofer Koester ,  James R. Manning ,  James Clifford Sutton ,  Benjamin Robert Taft ,  Lifeng Wan ,  Qian Zhao

IPC分类号： C07D487/14 ,  C07D471/14 ,  C07D491/22 ,  C07D498/14 ,  A61P31/16 ,  C07D513/14

摘要： The present invention provides a compound of Formula (I) including pharmaceutically acceptable salts thereof: (I) and therapeutic uses of these compounds. The invention further provides pharmaceutical compositions comprising these compounds, compositions comprising these compounds with a therapeutic co-agent, and methods of using the compounds and compositions to treat viral infections.

公开(公告)号：US10112931B2

公开(公告)日：2018-10-30

申请号：US15499824

申请日：2017-04-27

申请人： NOVARTIS AG

发明人： Thomas Raymond Caferro ,  Zhuoliang Chen ,  Young Shin Cho ,  Abran Q. Costales ,  Julian Roy Levell ,  Gang Liu ,  James R. Manning ,  Martin Sendzik ,  Cynthia Shafer ,  Michael David Shultz ,  James Clifford Sutton ,  Yaping Wang ,  Qian Zhao

IPC分类号： C07D413/14 ,  C07D413/04 ,  C07D417/14 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06

摘要： The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.

公开(公告)号：US09688672B2

公开(公告)日：2017-06-27

申请号：US15209731

申请日：2016-07-13

申请人： NOVARTIS AG

发明人： Thomas Raymond Caferro ,  Zhuoliang Chen ,  Young Shin Cho ,  Abran Q. Costales ,  Julian Roy Levell ,  Gang Liu ,  James R. Manning ,  Martin Sendzik ,  Cynthia Shafer ,  Michael David Shultz ,  James Clifford Sutton ,  Yaping Wang ,  Qian Zhao

IPC分类号： C07D413/14 ,  A61K31/506 ,  C07D413/04 ,  C07D417/14 ,  A61K31/5377

CPC分类号： C07D413/14 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D413/04 ,  C07D417/14

摘要： The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.

公开(公告)号：US10160764B2

公开(公告)日：2018-12-25

申请号：US15686652

申请日：2017-08-25

申请人： Novartis AG

发明人： Rama Jain ,  Dennis Christofer Koester ,  James R. Manning ,  Vanessa Marx ,  Daniel Poon ,  James Clifford Sutton ,  Benjamin R. Taft ,  Lifeng Wan ,  Aregahegn Yifru ,  Qian Zhao

IPC分类号： C07D487/14 ,  C07D471/14 ,  C07D498/14 ,  A61K31/5025

摘要： The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.

公开(公告)号：US11912715B2

公开(公告)日：2024-02-27

申请号：US17374237

申请日：2021-07-13

申请人： Novartis AG

发明人： Rama Jain ,  Dennis Christofer Koester ,  James R. Manning ,  Vanessa Marx ,  Daniel Poon ,  James Clifford Sutton ,  Benjamin R. Taft ,  Lifeng Wan ,  Aregahegn Yifru ,  Qian Zhao

IPC分类号： C07D487/14 ,  C07D471/14 ,  C07D498/14 ,  A61P31/16 ,  A61K31/551 ,  A61K31/53 ,  A61K31/5365 ,  A61K31/5383 ,  A61K31/5025

CPC分类号： C07D487/14 ,  A61K31/5025 ,  A61K31/53 ,  A61K31/5365 ,  A61K31/5383 ,  A61K31/551 ,  A61P31/16 ,  C07D471/14 ,  C07D498/14

摘要： The invention provides compounds of Formula (I):




as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.

公开(公告)号：US11098051B2

公开(公告)日：2021-08-24

申请号：US16328616

申请日：2017-08-25

申请人： Novartis AG

发明人： Rama Jain ,  Dennis Christofer Koester ,  James R. Manning ,  Vanessa Marx ,  Daniel Poon ,  James Clifford Sutton ,  Benjamin Robert Taft ,  Lifeng Wan ,  Aregahegn Yifru ,  Qian Zhao

IPC分类号： C07D487/14 ,  C07D471/14 ,  C07D498/14 ,  A61P31/16 ,  A61K31/16 ,  A61K31/5025 ,  A61K31/53 ,  A61K31/5365 ,  A61K31/5383 ,  A61K31/551

摘要： The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.

公开(公告)号：US10858366B2

公开(公告)日：2020-12-08

申请号：US16083089

申请日：2017-03-07

申请人： Novartis AG

发明人： Rama Jain ,  Dennis Christofer Koester ,  James R. Manning ,  James Clifford Sutton ,  Benjamin Robert Taft ,  Lifeng Wan ,  Qian Zhao

IPC分类号： C07D487/14 ,  C07D471/14 ,  C07D491/22 ,  C07D498/14 ,  A61P31/16 ,  C07D513/14

摘要： The present invention provides a compound of Formula (I) including pharmaceutically acceptable salts thereof: and therapeutic uses of these compounds. The invention further provides pharmaceutical compositions comprising these compounds, compositions comprising these compounds with a therapeutic co-agent, and methods of using the compounds and compositions to treat viral infections.