专利检索 ap:("Novartis AG") AND inv:"Benjamin R. Taft" 第 1 页

1.

发明授权
Biaryl amide compounds as kinase inhibitors 有权

公开(公告)号：US10709712B2

公开(公告)日：2020-07-14

申请号：US16274165

申请日：2019-02-12

申请人： NOVARTIS AG

发明人： Robert John Aversa , Paul Andrew Barsanti , Matthew T. Burger , Michael Patrick Dillon , Alan Dipesa , Cheng Hu , Yan Lou , Gisele A. Nishiguchi , Yue Pan , Valery Rostislavovich Polyakov , Savithri Ramurthy , Alice C. Rico , Lina Quattrocchio Setti , Aaron Smith , Sharadha Subramanian , Benjamin R. Taft , Huw Roland Tanner , Lifeng Wan , Naeem Yusuff

IPC分类号： A61K31/5377 , C07D413/04 , A61K31/541 , A61K45/06 , C07D213/74 , C07D237/20 , C07D239/42 , C07D239/47 , C07D239/48 , C07D277/42 , C07D401/12 , C07D403/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D493/10 , C07D403/12 , C07D401/14 , C07D405/14 , C07D213/75 , C07D233/88 , C07D401/04 , C07D405/04 , C07D405/12 , C07D241/20 , C07D471/04 , C07D487/04 , C07D263/58 , C07D491/107 , C07D493/04 , C07D495/04 , C07D498/08 , C07D513/04 , A61K31/5375 , C07D213/81 , C07D213/82 , C07D213/84 , C07D237/22 , C07D409/14 , C07D491/048 , A61K31/444 , A61K31/501 , C07B59/00 , C07D237/24 , C07D491/04 , C07D491/08

摘要： The present invention provides compounds of Formula (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.

2.

发明授权
Compounds and compositions as RAF kinase inhibitors 有权

公开(公告)号：US10167279B2

公开(公告)日：2019-01-01

申请号：US15510609

申请日：2015-09-11

申请人： NOVARTIS AG

发明人： Robert John Aversa , Matthew T. Burger , Michael Patrick Dillon , Thomas A. Dineen, Jr. , Yan Lou , Gisele A. Nishiguchi , Savithri Ramurthy , Alice C. Rico , Vivek Rauniyar , Martin Sendzik , Sharadha Subramanian , Lina Quattrocchio Setti , Benjamin R. Taft , Huw Rowland Tanner , Lifeng Wan

IPC分类号： C07D405/14 , C07D405/12 , C07D305/06 , A61P35/00 , C07D413/14

摘要： The present invention provides compounds of Formula (I) and (II) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.

3.

发明授权
Fused tricyclic pyridazinone compounds useful to treat orthomyxovirus infections 有权

公开(公告)号：US10160764B2

公开(公告)日：2018-12-25

申请号：US15686652

申请日：2017-08-25

申请人： Novartis AG

发明人： Rama Jain , Dennis Christofer Koester , James R. Manning , Vanessa Marx , Daniel Poon , James Clifford Sutton , Benjamin R. Taft , Lifeng Wan , Aregahegn Yifru , Qian Zhao

IPC分类号： C07D487/14 , C07D471/14 , C07D498/14 , A61K31/5025

摘要： The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.

4.

发明授权
Fused tricyclic pyridazinone compounds useful to treat orthomyxovirus infections 有权

公开(公告)号：US11912715B2

公开(公告)日：2024-02-27

申请号：US17374237

申请日：2021-07-13

申请人： Novartis AG

发明人： Rama Jain , Dennis Christofer Koester , James R. Manning , Vanessa Marx , Daniel Poon , James Clifford Sutton , Benjamin R. Taft , Lifeng Wan , Aregahegn Yifru , Qian Zhao

IPC分类号： C07D487/14 , C07D471/14 , C07D498/14 , A61P31/16 , A61K31/551 , A61K31/53 , A61K31/5365 , A61K31/5383 , A61K31/5025

CPC分类号： C07D487/14 , A61K31/5025 , A61K31/53 , A61K31/5365 , A61K31/5383 , A61K31/551 , A61P31/16 , C07D471/14 , C07D498/14

摘要： The invention provides compounds of Formula (I):

as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.

5.

发明授权
Compounds and compositions as kinase inhibitors 有权

公开(公告)号：US10392404B2

公开(公告)日：2019-08-27

申请号：US15510613

申请日：2015-09-11

申请人： NOVARTIS AG

发明人： Paul Andrew Barsanti , Matthew T. Burger , Yan Lou , Gisele A. Nishiguchi , Valery Rostislavovich Polyakov , Savithri Ramurthy , Sharadha Subramanian , Benjamin R. Taft , Huw Rowland Tanner , Lifeng Wan

IPC分类号： A61K31/444 , C07D498/08 , C07D401/14 , C07D413/14 , C07D213/74 , C07D401/04 , C07D401/10 , C07D407/14 , C07D411/14 , C07D413/12 , A61K31/4418 , A61K31/496 , A61K31/501 , A61K31/5377 , A61K31/541 , C07D213/85 , C07D405/12 , C07D405/14 , C07D451/02

摘要： The present invention provides compounds of Formula (I) and (II) as described herein, and salts thereof and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.