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公开(公告)号：US11912715B2
公开(公告)日：2024-02-27
申请号：US17374237
申请日：2021-07-13
申请人： Novartis AG
发明人： Rama Jain , Dennis Christofer Koester , James R. Manning , Vanessa Marx , Daniel Poon , James Clifford Sutton , Benjamin R. Taft , Lifeng Wan , Aregahegn Yifru , Qian Zhao
IPC分类号： C07D487/14 , C07D471/14 , C07D498/14 , A61P31/16 , A61K31/551 , A61K31/53 , A61K31/5365 , A61K31/5383 , A61K31/5025
CPC分类号： C07D487/14 , A61K31/5025 , A61K31/53 , A61K31/5365 , A61K31/5383 , A61K31/551 , A61P31/16 , C07D471/14 , C07D498/14
摘要： The invention provides compounds of Formula (I):
as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.-
公开(公告)号：US11098051B2
公开(公告)日：2021-08-24
申请号：US16328616
申请日：2017-08-25
申请人： Novartis AG
发明人： Rama Jain , Dennis Christofer Koester , James R. Manning , Vanessa Marx , Daniel Poon , James Clifford Sutton , Benjamin Robert Taft , Lifeng Wan , Aregahegn Yifru , Qian Zhao
IPC分类号： C07D487/14 , C07D471/14 , C07D498/14 , A61P31/16 , A61K31/16 , A61K31/5025 , A61K31/53 , A61K31/5365 , A61K31/5383 , A61K31/551
摘要： The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.
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![10-(di(phenyl)methyl)-4-hydroxy-8,9,9A,10-tetrahydro-7H-pyrrolo[1′,2′:4,5]pyrazino[1,2-b]pyridazine-3,5-dione derivatives and related compounds as inhibitors of the orthomyxovirus replication for treating influenza](/abs-image/US/2023/04/18/US11629149B2/abs.jpg.150x150.jpg)
公开(公告)号：US11629149B2
公开(公告)日：2023-04-18
申请号：US16975784
申请日：2019-02-26
申请人： Novartis AG
发明人： Maxime Dauphinais , Rama Jain , Dennis Christofer Koester , James R. Manning , Vanessa Marx , Daniel Poon , Lifeng Wan , Xiaojing Michael Wang , Aregahegn Yifru , Qian Zhao
IPC分类号： C07D487/14 , C07D498/14
摘要： The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.
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公开(公告)号：US10160764B2
公开(公告)日：2018-12-25
申请号：US15686652
申请日：2017-08-25
申请人： Novartis AG
发明人： Rama Jain , Dennis Christofer Koester , James R. Manning , Vanessa Marx , Daniel Poon , James Clifford Sutton , Benjamin R. Taft , Lifeng Wan , Aregahegn Yifru , Qian Zhao
IPC分类号： C07D487/14 , C07D471/14 , C07D498/14 , A61K31/5025
摘要： The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.
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![10-(di(phenyl)methyl)-4-hydroxy-8,9,9A,10-tetrahydro-7H-pyrrolo[1′,2′:4,5]pyrazino[1,2-b]pyridazine-3,5-dione derivatives and related compounds as inhibitors of the orthomyxovirus replication for treating influenza](/abs-image/US/2024/08/27/US12071441B2/abs.jpg.150x150.jpg)
公开(公告)号：US12071441B2
公开(公告)日：2024-08-27
申请号：US18114336
申请日：2023-02-27
申请人： Novartis AG
发明人： Maxime Dauphinais , Rama Jain , Dennis Christofer Koester , James R. Manning , Vanessa Marx , Daniel Poon , Lifeng Wan , Xiaojing Michael Wang , Aregahegn Yifru , Qian Zhao
IPC分类号： C07D487/14 , C07D498/14
CPC分类号： C07D487/14 , C07D498/14
摘要： The invention provides compounds of Formula (I):
as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.-
![10-(di(phenyl)methyl)-4-hydroxy-8,9,9A,10-tetrahydro-7H-pyrrolo[1 ',2':4,5]pyrazino[1,2-B]pyridazine-3,5-dione Derivatives and Related Compounds as Inhibitors of the Orthomyxovirus Replication for Treating Influenza](/abs-image/US/2023/10/12/US20230322793A1/abs.jpg.150x150.jpg)
公开(公告)号：US20230322793A1
公开(公告)日：2023-10-12
申请号：US18114336
申请日：2023-02-27
申请人： Novartis AG
发明人： Maxime Dauphinais , Rama Jain , Dennis Christofer Koester , James R. Manning , Vanessa Marx , Daniel Poon , Lifeng Wan , Xiaojing Michael Wang , Aregahegn Yifru , Qian Zhao
IPC分类号： C07D487/14 , C07D498/14
CPC分类号： C07D487/14 , C07D498/14
摘要： The invention provides compounds of Formula (I):
as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.
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