-
公开(公告)号：US20220387609A1
公开(公告)日：2022-12-08
申请号：US17599402
申请日：2020-03-26
发明人： Hiroki YOSHIOKA , Kazuki OSAKAMA , Mika HAMURA , Takanori INABA , Nobuhiro NISHIYAMA , Makoto MATSUI , Hiroyasu TAKEMOTO , Takahiro NOMOTO , Xiaohang SUN
摘要： A bio-related substance bonded to a branched and degradable polyethylene glycol derivative that is degraded in the cells represented by the following formula (A): wherein each symbol is as defined in the present specification, is provided by the present invention.
-
公开(公告)号：US20220153992A1
公开(公告)日：2022-05-19
申请号：US17599163
申请日：2020-03-26
发明人： Hiroki YOSHIOKA , Kazuki OSAKAMA , Mika HAMURA , Takanori INABA , Nobuhiro NISHIYAMA , Makoto MATSUI , Hiroyasu TAKEMOTO , Takahiro NOMOTO , Xiaohang SUN
IPC分类号： C08L71/02 , C08G65/333 , C08L101/16
摘要： An intracellularly degraded branched and degradable polyethylene glycol derivative represented by the following formula (1): wherein each symbol is as defined in the present specification, that is used for modifying bio-related substances is provided by the present invention.
-
公开(公告)号：US20210023231A1
公开(公告)日：2021-01-28
申请号：US17042039
申请日：2019-03-29
发明人： Hiroki YOSHIOKA , Masaki KAMIYA , Yuji YAMAMOTO , Midori HIRAI , Akiko SASAKI , Nobuhiro NISHIYAMA , Makoto MATSUI , Hiroyasu TAKEMOTO , Kazuki MIYAUCHI , Takahiro NOMOTO , Keishiro TOMODA
IPC分类号： A61K47/60 , C08G65/333 , C07K19/00 , C07K5/103 , C07K7/06 , A61K38/23 , A61K38/19 , A61K38/27
摘要： The invention provides a bio-related substance bonded to a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The bio-related substance bonded to a degradable polyethylene glycol derivative is represented by the formula (A):
wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, D is the bio-related substance, L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer, and y is 1-40.-
公开(公告)号：US20240301137A1
公开(公告)日：2024-09-12
申请号：US18577166
申请日：2022-07-06
发明人： Koichi OGI , Junya MICHINISHI , Tomoyuki OHTAKE , Muneaki IIZUKA , Nobuhiro NISHIYAMA , Hiroyasu TAKEMOTO , Yutaka MIURA , Takahiro NOMOTO , Makoto MATSUI , Yi-Jung SUNG , Masahiro TOYODA , Aria GHASEMIZADEH
摘要： The present invention provides a highly pure pH-responsive polymer represented by the following formula (I), a production method thereof, and the like:
(in the formula (I), each symbol is as described in the specification).-
公开(公告)号：US20210147624A1
公开(公告)日：2021-05-20
申请号：US17042711
申请日：2019-03-29
发明人： Hiroki YOSHIOKA , Masaki KAMIYA , Yuji YAMAMOTO , Midori HIRAI , Akiko SASAKI , Nobuhiro NISHIYAMA , Makoto MATSUI , Hiroyasu TAKEMOTO , Kazuki MIYAUCHI , Takahiro NOMOTO , Keishiro TOMODA
IPC分类号： C08G65/333 , C08G65/325 , A61K47/65
摘要： The invention provides a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The degradable polyethylene glycol derivative is represented by the following formula (1): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, X is a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer.
-
公开(公告)号：US20220211646A1
公开(公告)日：2022-07-07
申请号：US17605027
申请日：2020-04-23
摘要： A conjugate is provided in which a deferoxamine-type compound, which is at least one compound selected from the group consisting of deferoxamine or an ion or salt thereof, and a derivative thereof, and a biocompatible polymer are conjugated, where the biocompatible polymer contains a first biocompatible polymer chain and a second biocompatible polymer chain that is different from the first biocompatible polymer chain.
-
公开(公告)号：US20210040244A1
公开(公告)日：2021-02-11
申请号：US16963864
申请日：2019-02-19
发明人： Nobuhiro NISHIYAMA , Takahiro NOMOTO , Yukiya INOUE , Ying YAO , Kaito KANAMORI , Hiroyasu TAKEMOTO , Makoto MATSUI , Keishiro TOMODA
摘要： The present invention pertains to: a p-boronophenylalanine derivative that comprises a polymer to which a group represented by formula (I) is linked directly or via a linker; a composition containing same; and a kit for producing said derivative and composition.
-
公开(公告)号：US20200261476A1
公开(公告)日：2020-08-20
申请号：US16067906
申请日：2017-01-05
发明人： Hideyuki SAYA , Osamu NAGANO , Kenji TSUCHIHASHI , Kentaro SUINA , Nobuhiro NISHIYAMA , Hiroyasu TAKEMOTO , Takahiro NOMOTO , Makoto MATSUI , Keishiro TOMODA , Naoki YAMADA , Tsukasa NISHIMORI
IPC分类号： A61K31/635 , A61K47/60
摘要： The present invention is directed to provide antitumor agent including water-soluble sulfasalazine as an active ingredient. Antitumor agents were obtained with, as the water-soluble sulfasalazine, a PEG-modified sulfasalazine represented by the following formula: wherein an average value of n is 4 or larger and 1136 or smaller.
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.017 秒)
