公开(公告)号：US20210040244A1

公开(公告)日：2021-02-11

申请号：US16963864

申请日：2019-02-19

申请人： TOKYO INSTITUTE OF TECHNOLOGY ,  STELLA PHARMA CORPORATION

发明人： Nobuhiro NISHIYAMA ,  Takahiro NOMOTO ,  Yukiya INOUE ,  Ying YAO ,  Kaito KANAMORI ,  Hiroyasu TAKEMOTO ,  Makoto MATSUI ,  Keishiro TOMODA

IPC分类号： C08F8/42 ,  A61P35/00 ,  C08F16/06 ,  A61K47/60 ,  A61K31/69 ,  A61K9/00

摘要： The present invention pertains to: a p-boronophenylalanine derivative that comprises a polymer to which a group represented by formula (I) is linked directly or via a linker; a composition containing same; and a kit for producing said derivative and composition.

公开(公告)号：US20210147624A1

公开(公告)日：2021-05-20

申请号：US17042711

申请日：2019-03-29

申请人： NOF CORPORATION ,  TOKYO INSTITUTE OF TECHNOLOGY

发明人： Hiroki YOSHIOKA ,  Masaki KAMIYA ,  Yuji YAMAMOTO ,  Midori HIRAI ,  Akiko SASAKI ,  Nobuhiro NISHIYAMA ,  Makoto MATSUI ,  Hiroyasu TAKEMOTO ,  Kazuki MIYAUCHI ,  Takahiro NOMOTO ,  Keishiro TOMODA

IPC分类号： C08G65/333 ,  C08G65/325 ,  A61K47/65

摘要： The invention provides a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The degradable polyethylene glycol derivative is represented by the following formula (1): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, X is a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer.

公开(公告)号：US20210023231A1

公开(公告)日：2021-01-28

申请号：US17042039

申请日：2019-03-29

申请人： NOF CORPORATION ,  TOKYO INSTITUTE OF TECHNOLOGY

发明人： Hiroki YOSHIOKA ,  Masaki KAMIYA ,  Yuji YAMAMOTO ,  Midori HIRAI ,  Akiko SASAKI ,  Nobuhiro NISHIYAMA ,  Makoto MATSUI ,  Hiroyasu TAKEMOTO ,  Kazuki MIYAUCHI ,  Takahiro NOMOTO ,  Keishiro TOMODA

IPC分类号： A61K47/60 ,  C08G65/333 ,  C07K19/00 ,  C07K5/103 ,  C07K7/06 ,  A61K38/23 ,  A61K38/19 ,  A61K38/27

摘要： The invention provides a bio-related substance bonded to a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The bio-related substance bonded to a degradable polyethylene glycol derivative is represented by the formula (A):
wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, D is the bio-related substance, L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer, and y is 1-40.

公开(公告)号：US20200261476A1

公开(公告)日：2020-08-20

申请号：US16067906

申请日：2017-01-05

申请人： KEIO UNIVERSITY ,  TOKYO INSTITUTE OF TECHNOLOGY

发明人： Hideyuki SAYA ,  Osamu NAGANO ,  Kenji TSUCHIHASHI ,  Kentaro SUINA ,  Nobuhiro NISHIYAMA ,  Hiroyasu TAKEMOTO ,  Takahiro NOMOTO ,  Makoto MATSUI ,  Keishiro TOMODA ,  Naoki YAMADA ,  Tsukasa NISHIMORI

IPC分类号： A61K31/635 ,  A61K47/60

摘要： The present invention is directed to provide antitumor agent including water-soluble sulfasalazine as an active ingredient. Antitumor agents were obtained with, as the water-soluble sulfasalazine, a PEG-modified sulfasalazine represented by the following formula: wherein an average value of n is 4 or larger and 1136 or smaller.