公开(公告)号：US20160158297A1

公开(公告)日：2016-06-09

申请号：US15040492

申请日：2016-02-10

Applicant: NESTEC S.A.

Inventor： Annick Mercenier ,  Antoine Wermeille ,  Audrey Demont ,  Guenolee Prioult

IPC: A61K35/747 ,  A61K35/745

CPC classification number: A61K35/747 ,  A23K10/16 ,  A23K10/18 ,  A23K40/20 ,  A23K40/25 ,  A23L33/135 ,  A23P30/25 ,  A23V2002/00 ,  A23Y2220/03 ,  A23Y2220/15 ,  A23Y2220/17 ,  A23Y2220/43 ,  A23Y2220/49 ,  A23Y2220/63 ,  A23Y2220/71 ,  A23Y2220/73 ,  A23Y2240/75 ,  A23Y2300/29 ,  A23Y2300/49 ,  A23Y2300/55 ,  A61K8/99 ,  A61K35/742 ,  A61K35/744 ,  A61K35/745 ,  A61K2035/115 ,  A61K2800/10 ,  A61Q19/00 ,  Y02A50/473 ,  A23V2200/3204 ,  A23V2200/324

Abstract: Compositions include probiotic microorganisms that were rendered non-replicating by extrusion. Such compositions may be used to treat or prevent disorders that are related to a compromised immune system.

Abstract translation: 组合物包括通过挤压使其不复制的益生菌微生物。 这样的组合物可用于治疗或预防与受损免疫系统相关的病症。

公开(公告)号：US20150079056A1

公开(公告)日：2015-03-19

申请号：US14550156

申请日：2014-11-21

Applicant: NESTEC S.A.

Inventor： Annick Mercenier ,  Sophie Nutten ,  Guenolee Prioult

IPC: A61K35/74 ,  A23L1/30 ,  A23L1/29

CPC classification number: A61K35/745 ,  A23K10/18 ,  A23L33/135 ,  A23L33/40 ,  A23V2002/00 ,  A23Y2220/03 ,  A23Y2220/15 ,  A23Y2220/17 ,  A23Y2220/43 ,  A23Y2220/63 ,  A23Y2220/71 ,  A23Y2220/73 ,  A23Y2240/41 ,  A23Y2240/75 ,  A23Y2300/29 ,  A23Y2300/49 ,  A23Y2300/55 ,  A61K35/74 ,  A61K35/744 ,  A61K35/747 ,  C12N1/005 ,  C12N1/20 ,  C12N1/36 ,  Y02A50/473

Abstract: The present invention relates to the field of infant cereals. In particular, the present invention relates to the field of infant cereals that can be used to strengthen the immune system of the infant and/or that can be used to treat or prevent inflammatory disorders. For example these benefits can be provided by probiotic micro-organisms. An embodiment of the present invention relates to an infant cereal comprising non-replicating probiotic-micro-organisms, for example bioactive heat treated probiotic micro-organisms.

Abstract translation: 本发明涉及婴儿谷物领域。 特别地，本发明涉及可用于加强婴儿免疫系统和/或可用于治疗或预防炎症性疾病的婴儿谷物领域。 例如，这些益处可以由益生菌微生物提供。 本发明的一个实施方案涉及包含非复制益生菌微生物的婴儿谷物，例如生物活性热处理的益生菌微生物。

公开(公告)号：US20160250265A1

公开(公告)日：2016-09-01

申请号：US15151762

申请日：2016-05-11

Applicant: NESTEC S.A.

Inventor： Valerie Petit ,  Clara Lucia Garcia-Rodenas ,  Monique Julita ,  Annick Mercenier ,  Guenolee Prioult ,  Sophie Nutten

IPC: A61K35/747 ,  A61K35/744 ,  C12N1/36 ,  A61K35/745

CPC classification number: A61K35/747 ,  A61K35/74 ,  A61K35/741 ,  A61K35/742 ,  A61K35/744 ,  A61K35/745 ,  A61K38/00 ,  A61K39/00 ,  C12N1/20 ,  C12N1/36 ,  Y02A50/473

Abstract: The present invention relates to non-replicating probiotic micro-organisms and their health benefits. For example, the present invention relates to compositions comprising non-replicating probiotic micro-organisms for use in the treatment of prevention of upper respiratory tract infections and/or their symptoms. Embodiments of the present invention can help parents to protect their children from such upper respiratory tract infections.

Abstract translation: 本发明涉及非复制益生菌微生物及其健康益处。 例如，本发明涉及包含用于预防上呼吸道感染和/或其症状的非复制益生菌微生物的组合物。 本发明的实施例可以帮助父母保护他们的孩子免受这种上呼吸道感染。

公开(公告)号：US20150343002A1

公开(公告)日：2015-12-03

申请号：US14654166

申请日：2013-12-18

Applicant: L'OREAL ,  NESTEC S.A.

Inventor： Lionel Breton ,  Audrey Gueniche ,  Michela Zuccolo ,  Annick Mercenier ,  Guénolé Prioult

IPC: A61K35/745

CPC classification number: A61K35/745 ,  A61K8/99 ,  A61Q5/10 ,  A61Q19/04

Abstract: The present invention relates to the topical use of Bifidobacterium longum subsp. longum CNCM I-2618, as a pro-pigmenting agent, in particular in the prevention and/or treatment of alterations of skin and/or hair color homogeneity and for creating a uniform complexion.

Abstract translation: 本发明涉及长双歧杆菌的局部用途。 longum CNCM I-2618作为预着色剂，特别是用于预防和/或治疗皮肤和/或毛发颜色均匀性的改变并产生均匀的肤色。

公开(公告)号：US09226945B2

公开(公告)日：2016-01-05

申请号：US13773933

申请日：2013-02-22

Applicant: NESTEC S.A.

Inventor： Annick Mercenier ,  Marie-Claire Fichot ,  Adrian Zuercher

IPC: A61K38/01 ,  A23L1/29 ,  A23L1/305 ,  A61K38/18

CPC classification number: A61K38/018 ,  A23L33/18 ,  A23L33/40 ,  A23V2002/00 ,  A61K38/1841 ,  A23V2200/304 ,  A23V2250/204 ,  A23V2250/54252 ,  A23V2250/1882 ,  A23V2250/156 ,  A23V2250/70 ,  A23V2250/704

Abstract: A nutritional composition comprising a partially hydrolyzed milk protein having a degree of hydrolysis between 15 and 25% and 50 to 1000 nanograms of TGF-β per 100 ml of ready to consume composition and methods for the primary prevention of allergic reactions to newly introduced dietary protein at weaning and the prevention of development of atopic diseases in a young mammal at weaning comprising feeding to the young mammal a therapeutic amount of the composition are disclosed.

Abstract translation: 一种营养组合物，其包含部分水解的乳蛋白，其水解度为15至25％和50至1000纳克TGF-β; 每100ml预先消耗组合物和初步预防断奶时新引入的膳食蛋白质的过敏反应的组合物和方法，以及在断奶期间预防年轻哺乳动物中特应性疾病发展的组合物，其包括将治疗量的组合物 被披露。

公开(公告)号：US08802077B2

公开(公告)日：2014-08-12

申请号：US13901176

申请日：2013-05-23

Applicant: Nestec S.A.

Inventor： Velerie Petit ,  Clara Garcia-Rodenas ,  Monique Julita ,  Guenolee Prioult ,  Annick Mercenier ,  Sophie Nutten

IPC: A01N63/00

CPC classification number: A61K35/745 ,  A23K10/18 ,  A23L33/135 ,  A23L33/40 ,  A23V2002/00 ,  A23Y2220/03 ,  A23Y2220/15 ,  A23Y2220/17 ,  A23Y2220/43 ,  A23Y2220/63 ,  A23Y2220/71 ,  A23Y2220/73 ,  A23Y2240/41 ,  A23Y2240/75 ,  A23Y2300/29 ,  A23Y2300/49 ,  A23Y2300/55 ,  A61K35/747 ,  C12N1/36 ,  Y02A50/473

Abstract: The present invention generally relates to the field of preventing and/or treating inflammatory and infectious disorders, in particular by boosting the endogenous antimicrobial defences. One embodiment of the present invention is the use of B. longum NCC2705 (deposit number CNCM 1-2618) for use in the treatment or prevention of disorders related to the immune system including infections.

Abstract translation: 本发明一般涉及预防和/或治疗炎性和感染性疾病的领域，特别是通过增强内源性抗微生物防御。 本发明的一个实施方案是使用B. longum NCC2705（保藏号CNCM 1-2618）用于治疗或预防与包括感染在内的免疫系统相关的病症。

公开(公告)号：US10456429B2

公开(公告)日：2019-10-29

申请号：US14654166

申请日：2013-12-18

Applicant: L'OREAL ,  NESTEC S.A.

Inventor： Lionel Breton ,  Audrey Gueniche ,  Michela Zuccolo ,  Annick Mercenier ,  Guénolé Prioult

IPC: A61K35/745 ,  A61Q19/04 ,  A61K8/99 ,  A61Q5/10

Abstract: The present invention relates to the topical use of Bifidobacterium longum subsp. longum CNCM I-2618, as a pro-pigmenting agent, in particular in the prevention and/or treatment of alterations of skin and/or hair color homogeneity and for creating a uniform complexion.

公开(公告)号：US09839656B2

公开(公告)日：2017-12-12

申请号：US14372978

申请日：2013-01-16

Applicant: NESTEC S.A.

Inventor： Sebastien Holvoet ,  Annick Mercenier ,  Marietta Weiss ,  Adrian Walter Zuercher

IPC: A01N63/00 ,  A61K35/747 ,  A61K38/01 ,  A23L2/52 ,  A61K31/702 ,  A61K45/06 ,  A23K10/18 ,  A23L33/00 ,  A23L33/135 ,  A61K35/00

CPC classification number: A61K35/747 ,  A23K10/18 ,  A23L2/52 ,  A23L33/135 ,  A23L33/40 ,  A23V2002/00 ,  A23Y2220/39 ,  A61K31/702 ,  A61K38/018 ,  A61K45/06 ,  A61K2035/115 ,  A23V2200/304 ,  A23V2200/3204

Abstract: A composition comprising specific Lactobacillus helveticus strains is provided for reducing the symptoms of allergies originating from food, respiratory or contact allergens. Preferably the composition reduces symptoms of allergies (secondary prevention) while also able to reduce sensitization (primary prevention).

公开(公告)号：US20170000880A1

公开(公告)日：2017-01-05

申请号：US15267829

申请日：2016-09-16

Applicant: NESTEC S.A.

Inventor： Michael Affolter ,  Isabelle Bureau-Franz ,  Francoise Maynard ,  Annick Mercenier ,  Alexandre Panchaud

IPC: A61K39/35 ,  A23J3/34 ,  A61K38/01 ,  A23L33/18 ,  A23L33/19 ,  A23C9/152 ,  A23L33/00

CPC classification number: A61K39/35 ,  A23C9/1526 ,  A23J3/343 ,  A23J3/344 ,  A23L33/18 ,  A23L33/19 ,  A23L33/40 ,  A23V2002/00 ,  A61K38/018 ,  C12N9/52 ,  A23V2200/304 ,  A23V2250/55

Abstract: A composition including protein hydrolysates derived from milk is obtained by the treatment of enzymes derived from microorganisms. A trypsin-like enzyme and a chymotrypsin-like enzyme are used. The composition is in particular intended for inducing tolerance in infants with the effect of modulating the potential occurrence of allergies later in life. The composition can also be used in sick adult patients. Preferably the composition is an infant formula, infant follow-up formula, growing-up milk or baby food or an enteral complete nutritional composition.

Abstract translation: 通过处理来自微生物的酶获得包含来自牛奶的蛋白质水解产物的组合物。 使用胰蛋白酶样酶和胰凝乳蛋白酶样酶。 该组合物特别用于诱导婴儿的耐受性，其具有调节生命后期可能发生的过敏的作用。 该组合物也可用于病态成人患者。 优选地，组合物是婴儿配方食品，婴儿后续配方，成长中的牛奶或婴儿食品或肠内完全营养组合物。

公开(公告)号：US20150017143A1

公开(公告)日：2015-01-15

申请号：US14372978

申请日：2013-01-16

Applicant: NESTEC S.A.

Inventor： Sebastien Holvoet ,  Annick Mercenier ,  Marietta Weiss ,  Adrian Walter Zuercher

IPC: A61K35/74 ,  A23K1/00 ,  A23L1/30 ,  A23L2/52 ,  A61K31/702 ,  A61K45/06

CPC classification number: A61K35/747 ,  A23K10/18 ,  A23L2/52 ,  A23L33/135 ,  A23L33/40 ,  A23V2002/00 ,  A23Y2220/39 ,  A61K31/702 ,  A61K38/018 ,  A61K45/06 ,  A61K2035/115 ,  A23V2200/304 ,  A23V2200/3204

Abstract: A composition comprising specific Lactobacillus helveticus strains is provided for reducing the symptoms of allergies originating from food, respiratory or contact allergens. Preferably the composition reduces symptoms of allergies (secondary prevention) while also able to reduce sensitization (primary prevention).

Abstract translation: 提供包含特定的瑞士乳杆菌菌株的组合物用于减少源于食物，呼吸道或接触性过敏原的过敏症状。 优选地，组合物减少过敏症状（二次预防），同时还能够减少致敏（一级预防）。