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公开(公告)号：US20230012507A1
公开(公告)日：2023-01-19
申请号：US17780357
申请日：2020-11-25
发明人： Ananta Narayanan BALAJI , Yuan CHEN , Bo WANG , Li-Shiuan PEH , Huilin SHAO
IPC分类号： A61B5/145 , A61B5/0205 , A61B5/1455 , A61B5/00 , A61B5/1477 , G01N21/80
摘要： A wearable sweat sensor for detecting one or more analytes in human sweat comprises an optical module comprising at least one light source and at least one light detector; at least one sensor layer optically coupled to the optical module and having optical absorbance properties that are dependent on the concentration of a target analyte of said one or more analytes; and one or more processors in communication with the optical module. The one or more processors are configured to: cause light from the at least one light source to be transmitted towards, and/or through, the at least one sensor layer; obtain, from the at least one light detector, one or more optical signals reflected and/or transmitted from the at least one sensor layer; and determine, from at least one wavelength component of the one or more optical signals, a target analyte concentration.
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公开(公告)号：US20220236281A1
公开(公告)日：2022-07-28
申请号：US17615115
申请日：2020-05-19
IPC分类号： G01N33/68 , G01N33/543 , G01N33/53
摘要： Methods and systems including a set of interacting nucleic acid structures for use in detecting and/or identifying a target comprising: a nucleic acid sequence capable of being conjugated to a moiety directed to the target; and a nucleic acid nanostructure comprising a segment sequence complementary to a portion of the nucleic acid sequence capable of being conjugated to a moiety directed to the target. The moiety directed to the target may be an antibody, and the nucleic acid nanostructure may be a tetrahedron.
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公开(公告)号：US20220397580A1
公开(公告)日：2022-12-15
申请号：US17310253
申请日：2020-01-30
IPC分类号： G01N33/68 , G01N21/552
摘要： The present disclosure relates generally to the field of neurology. In particular, the disclosure relates to a method of detecting a neurodegenerative disease in a subject and methods of treatment thereof. The methods include detecting the level of an exosome-bound aggregated biomarker in a sample obtained from the subject, wherein an increased level of the exosome-bound aggregated biomarker as compared to a reference indicates that the subject is suffering from a neurodegenerative disease. Also described are methods for detecting a subject at risk of developing amyloidosis or a neurodegenerative disease, methods for detecting and treating amyloidosis or a neurodegenerative disease in a subject, and methods of determining the aggregation state of a biomarker in a sample.
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公开(公告)号：US20210130870A1
公开(公告)日：2021-05-06
申请号：US17257479
申请日：2019-07-02
发明人： Huilin SHAO , Nicholas Rui Yuan HO
IPC分类号： C12Q1/682 , C12N15/115 , C12M3/00 , C12M3/06
摘要： The present invention provides methods and devices for specific detection of nucleic acids using an integrated circuit of two independent enzyme-DNA nanostructures—an easily adjustable recognition element and a sensitive universal signaling element—to decouple target recognition and visual signal amplification. The recognition element comprises a DNA polymerase enzyme, a DNA polymerase enzyme-specific DNA aptamer and an inverter oligonucleotide. In the presence of a target nucleic acid, the inverter oligonucleotide binds to the target nucleic acid and releases the DNA polymerase enzyme from inhibition by the DNA aptamer. The activated DNA polymerase enzyme is then contacted with a signaling nanostructure comprising a self-priming portion responsive to the DNA polymerase enzyme, in the presence of labelled dNTPs and signal development reagents, wherein the activated DNA polymerase enzyme would add the labelled dNTPs to the self-priming portion, followed by the binding of the signal development reagents to the labelled dNTPs.
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公开(公告)号：US20220412982A1
公开(公告)日：2022-12-29
申请号：US17776920
申请日：2020-11-16
发明人： Huilin SHAO , Zhigang WANG , Xuecheng SUN
IPC分类号： G01N33/574 , G01N33/543 , G01N33/68 , G01N27/74
摘要： Devices and methods for analysing extracellular vesicle glycans are described. According to an embodiment, a microfluidic device comprises an inlet portion configured to receive a fluid sample; a mixing portion fluidically coupled to the inlet portion and configured to facilitate mixing between the fluid sample and magnetic nanoparticles functionalized to bind with extracellular vesicles and aggregate to vesicle glycans in the fluid sample; a magnetic separation portion fluidically coupled to the mixing portion and configured to separate clusters of magnetic nanoparticles from the fluid sample; and a magnetic sensor configured to measure magnetic properties of the fluid sample after it has passed through the magnetic separation portion. The magnetic nanoparticles may configured to aggregate in the presence of respective lectins when bound with extracellular vesicles carrying target glycans. In a specific embodiment, the magnetic particles comprise a magnetic polycore coated with polydopamine.
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公开(公告)号：US20220373562A1
公开(公告)日：2022-11-24
申请号：US17310289
申请日：2020-01-30
发明人： Huilin SHAO , Zhi Jun Carine LIM , Yan ZHANG
IPC分类号： G01N33/68 , G01N33/543 , G01N21/552 , G01N21/59 , G03F7/00 , G03F7/20
摘要： The present disclosure relates generally to a sensor chip and methods for the detection of an analyte. In particular, the disclosure relates to a sensor chip for detecting an analyte in a subject suffering from a neurodegenerative disease. The sensor chip comprises a conductive layer on a membrane support layer, wherein a plurality of apertures extend through the conductive layer and the membrane support layer and are arranged such that illumination of the conductive layer and/or the membrane support layer produces a surface plasmon resonance.
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