公开(公告)号：US20210268149A1

公开(公告)日：2021-09-02

申请号：US17044837

申请日：2019-09-11

Applicant: NANTONG UNIVERSITY

Inventor： Xin TANG ,  Cheng SUN ,  Gang CHEN ,  Xiaosong GU ,  Yumin YANG ,  Fei DING ,  Yanpei GONG ,  Qianru HE ,  Hongkui WANG ,  Mi SHEN

IPC: A61L27/36 ,  A61L27/38 ,  A61L27/54 ,  A61L27/56

Abstract: A differential tissue-engineered nerve including motor-like nerves and sensory-like nerves. The motor-like nerve and the sensory-like nerve respectively includes a motor-like nerve outer tube and a motor-like nerve fiber in the outer tube as well as a sensory-like nerve outer tube and a sensory-like nerve fiber in the outer tube. Schwann cells and/or fibroblasts derived from motor nerves and sensory nerves are respectively contained in surfaces or pores of the motor-like and sensory-like nerve outer tubes. Transsynaptic signal molecules Neuroligin-1 and Neuroligin-2 are contained in surfaces or pores of the motor-like and sensory-like nerve fibers. Neuroligin-1 is selectively used to specifically promote synaptic remodeling of motor neurons, while Neuroligin-2 is selectively used to specifically promote synaptic remodeling of sensory neurons, so that repair efficiency of motor nerve cells and sensory nerve cells is improved.

公开(公告)号：US20230210936A1

公开(公告)日：2023-07-06

申请号：US17996076

申请日：2020-08-05

Applicant: NANTONG UNIVERSITY

Inventor： Xiaosong GU ,  Chunkang TANG ,  Leilei GONG ,  Xiaomin WANG ,  Xin TANG

IPC: A61K36/8988 ,  A61K36/74 ,  A61K36/515 ,  A61K36/481 ,  A61K36/64 ,  A61K36/36 ,  A61K36/815 ,  A61K36/232 ,  A61K36/284 ,  A61K36/725 ,  A61K36/52 ,  A61K36/286 ,  A61K35/583 ,  A61P25/16

CPC classification number: A61K36/8988 ,  A61K36/74 ,  A61K36/515 ,  A61K36/481 ,  A61K36/64 ,  A61K36/36 ,  A61K36/815 ,  A61K36/232 ,  A61K36/284 ,  A61K36/725 ,  A61K36/52 ,  A61K36/286 ,  A61K35/583 ,  A61P25/16 ,  A61K2236/331 ,  A61K2236/37 ,  A61K2236/51

Abstract: A traditional Chinese medicine compound preparation for treating Parkinson's disease and its preparation method and application are disclosed. The traditional Chinese medicine compound preparation comprises traditional Chinese medicine formula components and the traditional Chinese medicine formula components comprise the following raw material or raw material extracts by mass: 6-15 parts of uncaria rhynchophylla, 3-9 parts of gastrodia elata, 6-12 parts of Gentiana macrophylla, 10-20 parts of raw astragalus membranaceus, 10-20 parts of prepared rehmannia roots, 10-20 parts of achyranthes roots, 10-20 parts of wolfberry fruits, 10-20 parts of angelica sinensis, 10-20 parts of fried atractylodes macrocephala, 6-15 parts of fried spina date seeds, 3-12 parts of walnut kernels, 3-9 parts of safflower, and 20-30 parts of zaocys dhumnade.

公开(公告)号：US20220395795A1

公开(公告)日：2022-12-15

申请号：US17628754

申请日：2021-01-15

Applicant: NANTONG UNIVERSITY

Inventor： Xin TANG ,  Cheng SUN ,  Xiaokun GU ,  Xiaosong GU ,  Qianru HE ,  Tianmei QIAN ,  Wenfeng SU ,  Haoming LI

IPC: B01J13/02 ,  C07K1/14 ,  C12N5/079

Abstract: Ag-Fe3O4 immunomagnetic microsphere contains poly-D-lysine modified on the surface and S100β and/or MBP antibody linked by an amide bond. The Ag-Fe3O4 immunomagnetic microsphere can specifically capturing peripheral nerve tissue-derived exosomes. When the microsphere is used to extract nerve tissue-derived exosomes, the extraction yield of exosomes per unit volume of nerve tissue is high, and the nerve specificity is strong.

公开(公告)号：US20220213437A1

公开(公告)日：2022-07-07

申请号：US17596647

申请日：2020-06-19

Applicant: NANTONG UNIVERSITY

Inventor： Xin TANG ,  Cheng SUN ,  Xiaosong GU ,  Youlang ZHOU ,  Chunkang TANG

IPC: C12N5/0793 ,  A61L27/26 ,  B82Y5/00 ,  C07K14/78

Abstract: A protein-modified PLGA microsphere can be used to construct tissue-engineered nerve. The microspheres are loaded with active substances for treating peripheral nerve injury and are bound to tissue-engineered nerves. It has been shown that the prepared tissue-engineered nerve effectively promotes nerve regeneration after peripheral nerve injury.

公开(公告)号：US20190111179A1

公开(公告)日：2019-04-18

申请号：US16089190

申请日：2017-04-05

Applicant: NANTONG UNIVERSITY

Inventor： Xiaosong GU ,  Fei DING ,  Xin TANG ,  Yumin YANG ,  Bin YU ,  Shiying LI ,  Songlin ZHOU ,  Luzhong ZHANG ,  Yaxian WANG ,  Yun GU ,  Hualin SUN

IPC: A61L27/36 ,  A61L27/54 ,  A61L27/56

Abstract: Provided is a use of one or more MicroRNA genes selected from miRNAs of Family Let-7, miR-21 or miR-222 in the construction of tissue engineered nerves and in the repair of peripheral nerve defects. An outer and/or internal surface or pores of a tissue engineered nerve graft are coated or adsorbed with polymeric nanomicrospheres carrying a Let-7 family miRNA inhibitor, miR-21, or miR-222, or a mimetic thereof, wherein the polymeric material is composed of biocompatible fibronectin and heparin. The regeneration of peripheral nerves and the construction of tissue engineered nerves are promoted by regulating the expression of MicroRNA genes which can effectively promote the proliferation of primary Schwann cells cultured in vitro and have an anti-apoptotic effect on neuronal cells. In-vivo test proves that bridging of the tissue engineered nerve graft can facilitate the regeneration of peripheral nerves, thus being useful in the treatment of peripheral nerve injury.