公开(公告)号：US11744894B2

公开(公告)日：2023-09-05

申请号：US16960054

申请日：2019-01-15

申请人： NANKAI UNIVERSITY

发明人： Yao Chen ,  Zhenjie Zhang ,  Yifan Feng

IPC分类号： A61K47/24 ,  A61K35/761 ,  A61K39/395 ,  A61K47/02

CPC分类号： A61K47/24 ,  A61K35/761 ,  A61K39/3955 ,  A61K47/02

摘要： A novel composite biological agent based on a porous frame material, comprising porous frame materials and biomolecules. The porous frame materials cover a biological product, wherein the porous frame materials are metal-organic frame material (MOFs), covalent organic frame materials (COFs), and hydrogen-bonding organic frame materials (HOFs), and the biomolecules are any one or a combination of antibodies, enzymes, peptides, vaccines, nucleotides, and virus species. The composite biological agent uses the porous frame materials and biomolecules to form a porous frame material/biomolecule complex, and the biomolecules are coated to achieve the protection effect. Under the premise of remaining biomolecule activity, the system can achieve efficient separation and recovery of the porous materials and the biomolecules, so that the technical problems of synthesis, storage, release, etc. are solved, a good technical effect is achieved, and the biomolecules are effectively protected. The system is applied to the storage and transportation of biological agents and preparation of novel agents.

公开(公告)号：US11648530B2

公开(公告)日：2023-05-16

申请号：US16960051

申请日：2018-12-29

申请人： NANKAI UNIVERSITY

发明人： Yao Chen ,  Zhenjie Zhang ,  Sainan Zhang

IPC分类号： B01J20/24 ,  B01J20/22 ,  B01J20/28 ,  B01J20/29 ,  B01J20/32 ,  B01D15/38

CPC分类号： B01J20/24 ,  B01D15/3833 ,  B01J20/226 ,  B01J20/2808 ,  B01J20/28083 ,  B01J20/29 ,  B01J20/3206 ,  B01J20/3217 ,  B01J20/3274 ,  B01J2220/52

摘要： A chiral stationary phase comprises a porous framework material and biomolecules. The porous framework material includes one of the metal-organic framework (MOF) material, the covalent organic framework (COF) material and the hydrogen-bonded organic framework (HOF) material. The biomolecules are biological chiral resolving agents. A pore size of the porous framework material is 0.2-15 nm. The porous framework material serves as a solid carrier. The biomolecules are loaded into the porous framework material. The porous framework material is modified with one or more of carboxyl, hydroxyl, amino, aldehyde, double bonds and mercapto groups.