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公开(公告)号：US08759365B2
公开(公告)日：2014-06-24
申请号：US12745105
申请日：2008-12-01
申请人： Muneto Mogi , Toshio Kawanami , Ken Yamada , Kayo Yasoshima , Hidetomo Imase , Takahiro Miyake , Osamu Ohmori
发明人： Muneto Mogi , Toshio Kawanami , Ken Yamada , Kayo Yasoshima , Hidetomo Imase , Takahiro Miyake , Osamu Ohmori
IPC分类号： A61K31/5377 , A61K31/506 , A61K31/41 , A61K31/40 , C07D413/14 , C07D405/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D207/14
CPC分类号： C07D207/14 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/14
摘要： The present invention provides a compound of formula (I): wherein the variants R1, R2, R3, R4, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.
摘要翻译： 本发明提供式（I）化合物：其中变体R1，R2，R3，R4，R6，R7如本文所定义，并且其中所述化合物是CETP的抑制剂，因此可用于治疗 由CETP介导的疾病或疾病或响应于CETP的抑制。
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公开(公告)号：US20100311750A1
公开(公告)日：2010-12-09
申请号：US12745105
申请日：2008-12-01
申请人： Muneto Mogi , Toshio Kawanami , Ken Yamada , Kayo Yasoshima , Hidetomo Imase , Takahiro Miyake , Osamu Ohmori
发明人： Muneto Mogi , Toshio Kawanami , Ken Yamada , Kayo Yasoshima , Hidetomo Imase , Takahiro Miyake , Osamu Ohmori
IPC分类号： A61K31/5377 , C07D207/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D257/06 , A61K31/40 , A61K31/506 , A61K31/41 , A61K31/496 , A61P3/06 , A61P9/10 , A61P3/00 , A61P9/00 , A61P7/12 , A61P9/12
CPC分类号： C07D207/14 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/14
摘要： The present invention provides a compound of formula (I): wherein the variants R1, R2, R3, R4, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.
摘要翻译： 本发明提供式（I）化合物：其中变体R1，R2，R3，R4，R6，R7如本文所定义，并且其中所述化合物是CETP的抑制剂，因此可用于治疗 由CETP介导的疾病或疾病或响应于CETP的抑制。
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公开(公告)号：US20090286790A1
公开(公告)日：2009-11-19
申请号：US12374463
申请日：2007-07-18
申请人： Hidetomo Imase , Yuki Iwaki , Toshio Kawanami , Takahiro Miyake , Muneto Mogi , Osamu Ohmori , Hongbo Qin , Ichiro Umemura , Ken Yamada , Kayo Yasoshima
发明人： Hidetomo Imase , Yuki Iwaki , Toshio Kawanami , Takahiro Miyake , Muneto Mogi , Osamu Ohmori , Hongbo Qin , Ichiro Umemura , Ken Yamada , Kayo Yasoshima
IPC分类号： A61K31/5377 , C07D211/58 , A61K31/4468 , C07D239/42 , A61K31/506 , C07D413/04 , A61P9/04 , A61P9/10 , A61P9/00
CPC分类号： C07D211/58 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14
摘要： The present invention provides a compound of formula (I): wherein the variants R1, R2, R3, R4, R5, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.
摘要翻译： 本发明提供式（I）化合物：其中变体R1，R2，R3，R4，R5，R6，R7如本文所定义，并且其中所述化合物是CETP的抑制剂，因此可用于 治疗由CETP介导的或对CETP的抑制作用的疾病或疾病。
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公开(公告)号：US08410275B2
公开(公告)日：2013-04-02
申请号：US13473649
申请日：2012-05-17
申请人： Masashi Kishida , Naoko Matsuura , Hidetomo Imase , Yuki Iwaki , Ichiro Umemura , Osamu Ohmori , Eiji Kawahara
发明人： Masashi Kishida , Naoko Matsuura , Hidetomo Imase , Yuki Iwaki , Ichiro Umemura , Osamu Ohmori , Eiji Kawahara
IPC分类号： C07D215/38
CPC分类号： C07D471/04 , C07D401/12 , C07D401/14
摘要： The present invention relates to novel compounds of formula (I) or a pharmaceutical composition thereof, with all the variables being defined in the text. The present invention further relates to the use of the compounds herein for treatment of or delay progression to overt to diseases in which CETP is involved.
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公开(公告)号：US08232403B2
公开(公告)日：2012-07-31
申请号：US12300208
申请日：2007-05-08
申请人： Masashi Kishida , Naoko Matsuura , Hidetomo Imase , Yuki Iwaki , Ichiro Umemura , Osamu Ohmori , Eiji Kawahara
发明人： Masashi Kishida , Naoko Matsuura , Hidetomo Imase , Yuki Iwaki , Ichiro Umemura , Osamu Ohmori , Eiji Kawahara
IPC分类号： A61K31/47 , C07D215/46
CPC分类号： C07D471/04 , C07D401/12 , C07D401/14
摘要： The present invention relates to novel compounds of formula (I) or a pharmaceutical composition thereof, with all the variables being defined in the text. The present invention further relates to the use of the compounds herein for treatment of or delay progression to overt to diseases in which CETP is involved.
摘要翻译： 本发明涉及新的式（I）化合物或其药物组合物，其全部变量在本文中定义。 本发明还涉及本文中的化合物用于治疗或延缓进展到涉及CETP的疾病的公开。
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公开(公告)号：US20090227580A1
公开(公告)日：2009-09-10
申请号：US12300208
申请日：2007-05-08
申请人： Masashi Kishida , Naoko Matsuura , Hidetomo Imase , Yuki Iwaki , Ichiro Umemura , Osamu Ohmori , Eiji Kawahara
发明人： Masashi Kishida , Naoko Matsuura , Hidetomo Imase , Yuki Iwaki , Ichiro Umemura , Osamu Ohmori , Eiji Kawahara
IPC分类号： A61K31/5377 , A61K31/506 , A61K31/4709 , C07D413/14 , C07D401/12
CPC分类号： C07D471/04 , C07D401/12 , C07D401/14
摘要： The present invention relates to novel compounds of formula (I) or a pharmaceutical composition thereof, with all the variables being defined in the text. The present invention further relates to the use of the compounds herein for treatment of or delay progression to overt to diseases in which CETP is involved.
摘要翻译： 本发明涉及新的式（I）化合物或其药物组合物，其全部变量在本文中定义。 本发明还涉及本文中的化合物用于治疗或延缓进展到涉及CETP的疾病的公开。
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7.发明申请2, 4-Pyrimidinediamines Useful In The Treatment Of Neoplastic Diseases, Inflammatory And Immune System Disorders 有权2，4-嘧啶二胺可用于治疗新生儿疾病，炎症和免疫系统疾病公开(公告)号：US20080132504A1
公开(公告)日：2008-06-05
申请号：US10568367
申请日：2004-08-13
申请人： Carlos Garcia-Echeverria , Takanori Kanazawa , Eiji Kawahara , Keiichi Masuya , Naoko Matsuura , Takahiro Miyake , Osamu Ohmori , Ichiro Umemura , Ruo Steensma , Greg Chopiuk , Jiqing Jiang , Yongqin Wan , Qiang Ding , Qiong Zhang , Nathanael Schiander Gray , Donald Karanewsky
发明人： Carlos Garcia-Echeverria , Takanori Kanazawa , Eiji Kawahara , Keiichi Masuya , Naoko Matsuura , Takahiro Miyake , Osamu Ohmori , Ichiro Umemura , Ruo Steensma , Greg Chopiuk , Jiqing Jiang , Yongqin Wan , Qiang Ding , Qiong Zhang , Nathanael Schiander Gray , Donald Karanewsky
IPC分类号： A61K31/506 , A61K31/497 , A61K31/535 , A61P29/00 , A61P35/00 , A61P37/00 , C07D239/48 , C07D403/12 , C07D413/12
CPC分类号： C07D239/48 , C04B35/632 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14
摘要： Novel pyrimidine derivatives of formula I to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them
摘要翻译： 式I的新型嘧啶衍生物用于其制备方法，它们作为药物的用途以及包含它们的药物组合物
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公开(公告)号：US08263590B2
公开(公告)日：2012-09-11
申请号：US13095760
申请日：2011-04-27
申请人： Carlos Garcia-Echeverria , Takanori Kanazawa , Eiji Kawahara , Keiichi Masuya , Naoko Matsuura , Takahiro Miyake , Osamu Ohmori , Ichiro Umemura
发明人： Carlos Garcia-Echeverria , Takanori Kanazawa , Eiji Kawahara , Keiichi Masuya , Naoko Matsuura , Takahiro Miyake , Osamu Ohmori , Ichiro Umemura
IPC分类号： C07D239/48 , A61K31/506
CPC分类号： C07D401/12 , C07D239/48 , C07D401/14
摘要： Novel pyrimidine derivatives of formula I to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译： 式I的新型嘧啶衍生物用于其制备方法，它们作为药物的用途以及包含它们的药物组合物。
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公开(公告)号：US20090131436A1
公开(公告)日：2009-05-21
申请号：US11574019
申请日：2005-08-26
申请人： Patricia Imbach , Eiji Kawahara , Kazuhide Konishi , Naoko Matsuura , Takahiro Miyake , Osamu Ohmori , Johannes Roesel , Naoki Teno , Ichiro Umemura
发明人： Patricia Imbach , Eiji Kawahara , Kazuhide Konishi , Naoko Matsuura , Takahiro Miyake , Osamu Ohmori , Johannes Roesel , Naoki Teno , Ichiro Umemura
IPC分类号： A61K31/5377 , C07D413/14 , A61K31/506 , C07D403/12 , A61P35/00
CPC分类号： C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D413/12
摘要： Novel pyrimidine derivatives of formula (I) to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译： 式（I）的新型嘧啶衍生物用于其制备方法，它们作为药物的用途以及包含它们的药物组合物。
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公开(公告)号：US20110201606A1
公开(公告)日：2011-08-18
申请号：US13095760
申请日：2011-04-27
申请人： Carlos Garcia-Echeverria , Takanori Kanazawa , Eiji Kawahara , Keiichi Masuya , Naoko Matsuura , Takahiro Miyake , Osamu Ohmori , Ichiro Umemura
发明人： Carlos Garcia-Echeverria , Takanori Kanazawa , Eiji Kawahara , Keiichi Masuya , Naoko Matsuura , Takahiro Miyake , Osamu Ohmori , Ichiro Umemura
IPC分类号： A61K31/5383 , C07D239/48 , C07D401/12 , C07D413/12 , C07D403/14 , C07D265/36 , A61K31/506 , A61K31/505 , A61K31/5377 , A61K31/497 , A61P35/00
CPC分类号： C07D401/12 , C07D239/48 , C07D401/14
摘要： Novel pyrimidine derivatives of formula I to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them
摘要翻译： 式I的新型嘧啶衍生物用于其制备方法，它们作为药物的用途以及包含它们的药物组合物
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