SPIRO-SUBSTITUTED PYRROLOPYRIMIDINES
    10.
    发明申请
    SPIRO-SUBSTITUTED PYRROLOPYRIMIDINES 审中-公开
    螺旋取代的吡咯烷酮

    公开(公告)号:US20090186889A1

    公开(公告)日:2009-07-23

    申请号:US12413996

    申请日:2009-03-30

    CPC分类号: C07D519/00

    摘要: The invention provides compounds of formula I or a pharmaceutically acceptable salt or ester thereof formula I wherein the symbols have the meaning as defined in the description. Said compounds are inhibitors of cathepsin K and/or cathepsin S and are useful for the treatment of diseases and medical conditions in which cathepsin K and or cathepsin S is implicated, e.g. various disorders including neuropathic pain, inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis, multiple sclerosis and tumours.

    摘要翻译: 本发明提供式I化合物或其药学上可接受的盐或其式I的化合物,其中符号具有如说明书中所定义的含义。 所述化合物是组织蛋白酶K和/或组织蛋白酶S的抑制剂,并且可用于治疗涉及组织蛋白酶K和/或组织蛋白酶S的疾病和医学病症。 各种疾病,包括神经性疼痛,炎症,类风湿性关节炎,骨关节炎,骨质疏松症,多发性硬化和肿瘤。