公开(公告)号：US20090091045A1

公开(公告)日：2009-04-09

申请号：US12226690

申请日：2007-04-25

申请人： Mitsuru Tanikawa ,  Takashi Watanabe ,  Takashi Nishimura

发明人： Mitsuru Tanikawa ,  Takashi Watanabe ,  Takashi Nishimura

IPC分类号： H01L23/29 ,  C08L83/04

CPC分类号： C08G59/306 ,  C08G59/42 ,  C08G77/14 ,  C09D183/06 ,  H01L23/296 ,  H01L33/56 ,  H01L2224/45144 ,  H01L2224/48091 ,  H01L2224/73204 ,  H01L2224/73265 ,  H01L2924/00014 ,  H01L2924/00

摘要： A thermosetting composition for an optical semiconductor containing a silicone resin having a cyclic ether-containing groups and a thermosetting agent capable of reacting with said cyclic ether-containing group, wherein the silicone resin has, as the principal components, a structural unit expressed by the following formula (1) and a structural unit expressed by the following formula (2). The content of the structural unit expressed by the formula (1) is 0.6 to 0.95 (on a molar basis) and the content of the structural unit expressed by the formula (2) is 0.05 to 0.4 (on a molar basis) when total number of the structural units contained is taken as 1, and the content of the cyclic ether-containing group is 5 to 40 mol %:[formula 1] (R1R2SiO2/2)  (1) and [formula 2] (R3SiO3/2)  (2) at least one of R1, R2 and R3 represents a cyclic ether-containing group, R1, R2 and R3 other than the cyclic ether-containing group represent hydrocarbon having 1 to 8 carbon atoms or fluoride thereof.

摘要翻译： 一种用于光学半导体的热固性组合物，其含有具有环状含醚基团的硅氧烷树脂和能够与所述含环状醚基团反应的热固性涂料，其中所述硅树脂具有以下成分的结构单元： （1）表示的结构单元和下述式（2）表示的结构单元。 由式（1）表示的结构单元的含量为0.6〜0.95（摩尔数），式（2）表示的结构单元的含量为0.05〜0.4（摩尔数），当总数 所含的结构单元为1，含环状醚的基团的含量为5〜40摩尔％：[式1] <？在线式描述=“在线式”末端=“铅 （R1R2SiO2 / 2）（1）<？in-line-formula description =“In-line formula”end =“tail”？>和[formula 2] <？in-line-formula description =“In- （R3SiO3 / 2）（2）<？in-line-formula description =“In-line Formulas”end =“tail”？> R1，R2和R3中的至少一个表示 除含环状醚的基团以外的含环状醚的基团R1，R2和R3表示碳原子数为1〜8的碳原子或氟原子。

公开(公告)号：US08084530B2

公开(公告)日：2011-12-27

申请号：US12452058

申请日：2008-06-13

申请人： Mitsuru Tanikawa ,  Takashi Watanabe ,  Takashi Nishimura

发明人： Mitsuru Tanikawa ,  Takashi Watanabe ,  Takashi Nishimura

IPC分类号： C08K3/34 ,  H01J1/62

CPC分类号： H01L23/296 ,  C08L83/12 ,  H01L33/56 ,  H01L2224/45144 ,  H01L2224/48091 ,  H01L2224/73204 ,  H01L2224/73265 ,  H01L2924/00014 ,  H01L2924/00

摘要： The sealing agent for an optical semiconductor device, which comprises: a silicone resin having a cyclic ether-containing group in the molecular structure; a heat curing agent capable of reacting with the cyclic ether-containing group; and a fine particulate material of silicon oxide, and the sealing agent having a viscosity of 500 to 10,000 mPa·s measured by an E-type viscometer at 25° C. at 5 rpm, a thixotropic value of 1.2 to 2.5 calculated by dividing a viscosity measured by the E-type viscometer at 25° C. at 1 rpm by a viscosity measured at 10 rpm (viscosity at 1 rpm/viscosity at 10 rpm), and a minimum viscosity of 100 mPa·s or higher measured at 1 s−1 in the temperature range of 25° C. to a curing temperature by a parallel plate rheometer.

摘要翻译： 一种光学半导体装置用密封剂，其特征在于，具有：具有分子结构的含环状醚的基团的有机硅树脂; 能够与含环状醚的基团反应的热固化剂; 和氧化硅微粒材料，密封剂的粘度为500〜10,000mPa·s，用E型粘度计在25℃，5rpm下测定，触变值为1.2〜2.5，除以 通过E型粘度计在25℃，1rpm下以10rpm（1rpm下的粘度/ 10rpm的粘度）测定的粘度，在1秒时测定的最小粘度为100mPa·s以上 -1，在25℃的温度范围内，通过平行板流变仪测定固化温度。

公开(公告)号：US20100171414A1

公开(公告)日：2010-07-08

申请号：US12452058

申请日：2008-06-13

申请人： Mitsuru Tanikawa ,  Takashi Watanabe ,  Takashi Nishimura

发明人： Mitsuru Tanikawa ,  Takashi Watanabe ,  Takashi Nishimura

IPC分类号： H01J1/62 ,  C08K3/34

CPC分类号： H01L23/296 ,  C08L83/12 ,  H01L33/56 ,  H01L2224/45144 ,  H01L2224/48091 ,  H01L2224/73204 ,  H01L2224/73265 ,  H01L2924/00014 ,  H01L2924/00

摘要： The sealing agent for an optical semiconductor device, which comprises: a silicone resin having a cyclic ether-containing group in the molecular structure; a heat curing agent capable of reacting with the cyclic ether-containing group; and a fine particulate material of silicon oxide, and the sealing agent having a viscosity of 500 to 10,000 mPa·s measured by an E-type viscometer at 25° C. at 5 rpm, a thixotropic value of 1.2 to 2.5 calculated by dividing a viscosity measured by the E-type viscometer at 25° C. at 1 rpm by a viscosity measured at 10 rpm (viscosity at 1 rpm/viscosity at 10 rpm), and a minimum viscosity of 100 mPa·s or higher measured at 1 s−1 in the temperature range of 25° C. to a curing temperature by a parallel plate rheometer.

摘要翻译： 一种光学半导体装置用密封剂，其特征在于，具有：具有分子结构的含环状醚的基团的有机硅树脂; 能够与含环状醚的基团反应的热固化剂; 和氧化硅微粒材料，密封剂的粘度为500〜10,000mPa·s，用E型粘度计在25℃，5rpm下测定，触变值为1.2〜2.5，除以 通过E型粘度计在25℃，1rpm下以10rpm（1rpm下的粘度/ 10rpm的粘度）测定的粘度，在1秒时测定的最小粘度为100mPa·s以上 -1，在25℃的温度范围内，通过平行板流变仪测定固化温度。

公开(公告)号：US20120153342A1

公开(公告)日：2012-06-21

申请号：US13392911

申请日：2011-06-07

申请人： Takashi Nishimura ,  Takashi Watanabe

发明人： Takashi Nishimura ,  Takashi Watanabe

IPC分类号： H01L33/00 ,  C08K3/38 ,  C09J183/07 ,  C08K3/26

CPC分类号： H01L33/641 ,  C08G77/12 ,  C08G77/20 ,  C08K3/26 ,  C08K3/38 ,  C08K2003/267 ,  C08L83/00 ,  C08L83/04 ,  C09J183/04 ,  H01L2224/32245 ,  H01L2224/48091 ,  H01L2224/48247 ,  H01L2224/73265 ,  H01L2924/00014 ,  H01L2924/00

摘要： The present invention provides a die bonding material for an optical semiconductor device which has high thermal conductivity and can prevent cracking in an optical semiconductor device including the die bonding material.The die bonding material for an optical semiconductor device includes: a first silicone resin containing a hydrogen atom bonded to a silicon atom, a second silicone resin not containing a hydrogen atom bonded to a silicon atom, but containing an alkenyl group, a catalyst for hydrosilylation reaction, and at least one substance selected from the group consisting of anhydrous magnesium carbonate represented by chemical formula MgCO3 not containing crystal water and coated bodies including the anhydrous magnesium carbonate and an organic resin, a silicone resin, or silica coated on the surface thereof.

摘要翻译： 本发明提供了一种具有高导热性并且可以防止包括芯片接合材料的光学半导体器件中的开裂的用于光学半导体器件的芯片接合材料。 用于光学半导体器件的芯片接合材料包括：含有与硅原子键合的氢原子的第一有机硅树脂，不含与硅原子键合但含有烯基的氢原子的第二硅氧烷树脂，氢化硅烷化催化剂 反应，以及选自不含结晶水的化学式MgCO 3表示的无水碳酸镁和包含无水碳酸镁的有机树脂，有机硅树脂或涂布在其表面上的二氧化硅的二氧化硅中的至少一种物质。

公开(公告)号：US09205111B2

公开(公告)日：2015-12-08

申请号：US10583860

申请日：2004-12-22

申请人： Takashi Nishimura ,  Masaki Yasukawa

发明人： Takashi Nishimura ,  Masaki Yasukawa

IPC分类号： C12N5/00 ,  C12N5/08 ,  C12N15/63 ,  C07H21/04 ,  A01N63/00 ,  A61K39/395 ,  A61K48/00 ,  A61K35/26 ,  A61K39/00 ,  C12N5/0783 ,  C12N15/85 ,  C12N5/16

CPC分类号： A61K35/26 ,  A61K39/0011 ,  A61K39/395 ,  A61K2039/5156 ,  C07H21/04 ,  C12N5/0636 ,  C12N5/16 ,  C12N15/63 ,  C12N15/85

摘要： A novel process for preparing tumor-specific T cells is disclosed. According to the invention, antitumor-active, tumor-specific T cells are prepared by transducing a TCR gene from a tumor-specific CTL into antitumor-active T cells that have been nonspecifically activated, thus enabling tumor-specific cellular immunotherapy to be carried out from even small amounts of blood. MHC class I-restricted, tumor-specific Th cells are obtained by the method, allowing for the production of cells that react with tumor cells expressing an MHC class I molecule and show a helper activity and an antitumor activity.

摘要翻译： 公开了一种制备肿瘤特异性T细胞的新方法。 根据本发明，通过将来自肿瘤特异性CTL的TCR基因转导至非特异性激活的抗肿瘤活性T细胞来制备抗肿瘤活性的肿瘤特异性T细胞，从而能够进行肿瘤特异性细胞免疫治疗 从少量的血液。 通过该方法获得MHC I类限制性肿瘤特异性Th细胞，允许产生与表达MHC I类分子的肿瘤细胞反应并显示辅助活性和抗肿瘤活性的细胞。

公开(公告)号：US20130202588A1

公开(公告)日：2013-08-08

申请号：US13700355

申请日：2011-05-27

申请人： Takashi Nishimura

发明人： Takashi Nishimura

IPC分类号： A61K39/395 ,  A61K31/7068

CPC分类号： A61K39/3955 ,  A61K31/7068 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/2815 ,  C07K16/2866 ,  A61K2300/00

摘要： An objective of the present invention is to provide novel therapeutic agents for cancer, which have an excellent antitumor effect in cancer patients by enhancing their immune function. The present inventors discovered that the administration of at IL-6 inhibitor and/or gemcitabine or a salt thereof to tumor-bearing organisms yields an excellent antitumor T cell response-enhancing effect, and completed the present invention. In addition, the present inventors discovered that the T cell response-enhancing effect produces an excellent antitumor effect.

摘要翻译： 本发明的目的是提供新的癌症治疗剂，其通过增强其免疫功能在癌症患者中具有优异的抗肿瘤作用。 本发明人发现IL-6抑制剂和/或吉西他滨或其盐对荷瘤生物的产生产生优异的抗肿瘤T细胞应答增强作用，并完成了本发明。 此外，本发明人发现，T细胞应答增强效果产生优异的抗肿瘤效果。

公开(公告)号：US20120100961A1

公开(公告)日：2012-04-26

申请号：US13321510

申请日：2010-05-17

申请人： Takashi Nishimura

发明人： Takashi Nishimura

IPC分类号： A63B21/005 ,  A63B21/062

CPC分类号： A63B21/062 ,  A63B21/0628 ,  A63B21/063 ,  A63B24/00

摘要： An electromechanical system for selecting weights in fitness station weight towers, wherein a vertical hollow rod, fixed to the cursor which fastens to the steel cable, which lifts the plates of unit weight, extends traversing central holes of these plates, traversing the upper wall of the base of the tower, which is hollow, this rod having a rotating shaft or screw that moves the weight selector upwards and downwards, mounted on the rod by bearings, and projecting below this bearing where it has at the end radial teeth that incase between protrusions existing in a circular low relief of a pulley, which is mounted on a bearing whose shaft is collinear to the rod and fixed to the lower face of the base, this pulley having a channel for a belt, driven by an electric motor fixed to the base.

摘要翻译： 一种用于在健身站重量塔中选择重量的机电系统，其中固定到光标上的垂直中空杆，其固定到钢缆上，该钢丝绳提升单元重量的板，延伸穿过这些板的中心孔，穿过上述 塔的底部是中空的，该杆具有通过轴承将重量选择器向上和向下移动的旋转轴或螺钉，并且在该轴承的下方突出，在该轴承处具有位于其之间的径向齿 存在于滑轮的圆形低浮雕中的突起，其安装在轴与杆共线并固定到基座的下表面的轴承上，该滑轮具有用于固定到 的基地。

公开(公告)号：US20120094809A1

公开(公告)日：2012-04-19

申请号：US13262138

申请日：2010-03-30

申请人： Takashi Nishimura

发明人： Takashi Nishimura

IPC分类号： A63B21/06

CPC分类号： A63B23/12 ,  A63B21/062 ,  A63B21/0628 ,  A63B21/063 ,  A63B21/4047 ,  A63B23/03525 ,  A63B23/0494 ,  A63B24/0087 ,  A63B2225/107

摘要： A floor of a gym's weight room is configured to encompass the installation of weight stations with weight towers controlled remotely from a control panel, with said weight station assembled atop a weight room floor. The floor of the gym, for each station-tower combination, includes two reinforced boxes embedded in the floor, each having an opening at floor level, wherein one box is located below the base of the weight station and one box is located in front of the respective weight tower, preferably positioned far from the station, the two boxes being connected by at least two parallel tubes located beneath the level of the gym's floor, and wherein the interior of each box is affixed with a cable pulley and bearing, each cable pulley being at a level so that the horizontal section of a steel cable runs toward a center of one of the tubes.

摘要翻译： 健身房的重量室的地板被配置为包括重量台的安装，其具有从控制面板远程控制的重量塔，所述重量站组装在重量室的地板上。 健身房的地板，对于每个站 - 塔组合，包括两个加强箱嵌入地板，每个在地面上具有开口，其中一个箱位于重量站的底部下方，一个箱位于 相应的重量塔，优选地位于远离工位的两个箱体通过位于健身房地板的水平面下方的至少两个平行管连接，并且其中每个箱体的内部固定有电缆滑轮和轴承，每个电缆 滑轮处于水平面，使钢缆的水平段朝向其中一个管的中心延伸。

公开(公告)号：US07938762B2

公开(公告)日：2011-05-10

申请号：US12304404

申请日：2006-11-10

申请人： Takashi Nishimura

发明人： Takashi Nishimura

IPC分类号： A63B21/008 ,  A63B21/005 ,  A63B21/062

CPC分类号： A63B21/0628 ,  A63B21/063 ,  A63B24/00

摘要： An automatic weight stack controller for fitness units adapted to a frame provided with weights piled up is disclosed, wherein the weights are provided with central vertical holes having inner circular grooves and a tube fit into said central holes, said tube being provided with radial holes disposed at the level of each weight wherein balls are housed, so that said balls can be pushed towards the grooves by a piston that slides vertically inside the tube, having conical ends and threaded on a vertical threaded bar centrally to the tube, where there is an eyelet for the steel cable designed to raise the weights, the selection of weights being carried out through a panel of instruments, with a digital display, and buttons to increase or decrease the number of weights.

摘要翻译： 公开了一种用于健身器具的自动重量堆叠控制器，其适用于装有堆重物的框架，其中重物设置有具有内圆形凹槽的中心垂直孔和配合到所述中心孔中的管，所述管设置有径向孔， 在其中容纳球的每个重量的水平面上，使得所述球可以通过在管内垂直滑动的活塞而被推向凹槽，该活塞具有锥形端并且在垂直螺纹杆上螺纹连接到管的中心，其中存在 设计用于提高重量的钢丝绳的孔眼，通过一组仪器进行的重量选择，具有数字显示器，以及用于增加或减少重量的按钮。

公开(公告)号：US20110095100A1

公开(公告)日：2011-04-28

申请号：US12996353

申请日：2008-10-20

申请人： Takashi Nishimura

发明人： Takashi Nishimura

IPC分类号： F23D14/28

CPC分类号： B05B7/2472 ,  A01C23/047 ,  B05B7/2416 ,  B05B7/2467 ,  B05B7/2475 ,  B05B7/2481 ,  B05B7/32 ,  B05B9/0877

摘要： Safe handling spraying device, which comprises a reservoir where is assembled an actuating lever or, manually or automatically actuating air pumps, that perform the internal reservoir pressurization. Inside of it, there is a pressure chamber where is stored water and the Chemical Concentrated product that is inside a pliable tightly closed bag. The reservoir (10) is designed for supplying water (Ag), the chemical concentrated product (CCP) is stored separately in a pliable container (12). The pliable container (12) is disposed inside of a pressure chamber or water reservoir (10), so that the same pressure defined inside the reservoir (10) is applied to the pliable container (12) simultaneously. The output end of the pliable container (12) is connected to the inlet of a mixing device (20) which doses the CCP continuously. After the CCP had been mixed with water, it communicates with a hose provided with an actuating trigger (30) and spraying nozzle (27) at the free end.

摘要翻译： 安全处理喷涂装置，其包括储存器，其中组装有执行内部储存器加压的致动杆或手动或自动致动空气泵。 在它的内部，有一个压力室，储存的水和化学浓缩产品在一个柔软的密闭袋子里面。 蓄水池（10）设计用于供水（Ag），化学浓缩产品（CCP）分别存储在柔性容器（12）中。 柔性容器（12）设置在压力室或储水器（10）的内部，使得限定在储存器（10）内的相同压力同时施加到柔性容器（12）。 柔性容器（12）的输出端连接到连续对CCP施加剂量的混合装置（20）的入口。 在CCP与水混合之后，它与一个带有致动触发器（30）的软管和自由端的喷嘴（27）连通。