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公开(公告)号：US5888781A
公开(公告)日：1999-03-30
申请号：US815851
申请日：1997-03-12
Applicant: Michael Sierks , Sateesh Natarajan
Inventor： Michael Sierks , Sateesh Natarajan
CPC classification number: C13K1/06
Abstract: A method for increasing the catalytic rate of starch hydrolases comprising reacting a starch hydrolase with a substrate therefor in the presence of about 0.001 to 80% (w/v) of an ethylene glycol or polyethylene glycol.
Abstract translation: 一种用于提高淀粉水解酶的催化速率的方法，包括在约0.001至80％（w / v）的乙二醇或聚乙二醇的存在下使淀粉水解酶与其底物反应。
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2.发明申请MORPHOLOGY AND PROTEIN SPECIFIC REAGENTS AS DIAGNOSTICS FOR NEURODEGENERATIVE DISEASES 审中-公开形态学和蛋白质特异性试剂作为神经病变疾病的诊断公开(公告)号：US20140011691A1
公开(公告)日：2014-01-09
申请号：US13821185
申请日：2011-10-26
Applicant: Michael Sierks , Srinath Kasturirangan , Sharareh Emadi , Shalini Prasad
Inventor： Michael Sierks , Srinath Kasturirangan , Sharareh Emadi , Shalini Prasad
IPC: G01N33/543 , G01N33/68
CPC classification number: C07K16/18 , A61K38/1716 , A61K39/3955 , C07K16/005 , C07K2317/569 , C07K2317/622 , C07K2317/73 , C07K2317/76 , G01N33/5438 , G01N33/54386 , G01N33/6857 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
Abstract: The invention relates to devices and diagnostic methods using the devices for detecting the presence of neurodegenerative diseases. The device (a “biosensor”) distinguishes between different neurodegenerative diseases and facilitates pre-symptomatic diagnoses.
Abstract translation: 本发明涉及使用该装置检测神经变性疾病的存在的装置和诊断方法。 该装置（“生物传感器”）区分不同的神经变性疾病并促进预先症状诊断。
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公开(公告)号：US08617549B2
公开(公告)日：2013-12-31
申请号：US13395011
申请日：2010-09-08
Applicant: Michael Sierks , Shanta Boddapati , Srinath Kasturirangan
Inventor： Michael Sierks , Shanta Boddapati , Srinath Kasturirangan
IPC: A61K39/395 , C07K16/46 , C07K16/18
CPC classification number: C07K16/18 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/70
Abstract: The present invention provides for the treatment of Alzheimer's disease. More specifically, a recombinant bispecific antibody fragment that simultaneously blocks beta-secretase activity while also promoting alpha-secretase activity, comprising a first portion and a second portion, wherein the first portion blocks beta secretase activity and the second portion promotes alpha-secretase activity.
Abstract translation: 本发明提供了阿尔茨海默病的治疗。 更具体地，重组双特异性抗体片段，其同时阻断β-分泌酶活性同时也促进α-分泌酶活性，其包含第一部分和第二部分，其中第一部分阻断β分泌酶活性，第二部分阻止β-分泌酶活性。
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公开(公告)号：US20220260593A1
公开(公告)日：2022-08-18
申请号：US17618869
申请日：2020-06-12
Applicant: Michael Sierks , Stephanie Williams
Inventor： Michael Sierks , Stephanie Williams
Abstract: Disclosed herein are antibodies, antibody fragments, binding agents, and compositions that specifically recognize protein variant biomarkers associated with frontotemporal dementia, kits and methods of use, including diagnosing, monitoring and treating frontotemporal dementia.
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5.发明授权Antibody based reagent that specifically recognizes toxic oligomeric form of beta-amyloid 有权特异性识别β-淀粉样蛋白的毒性低聚形式的基于抗体的试剂公开(公告)号：US09567393B2
公开(公告)日：2017-02-14
申请号：US13821172
申请日：2011-10-26
Applicant: Michael Sierks , Srinath Kasturirangan
Inventor： Michael Sierks , Srinath Kasturirangan
IPC: C07K16/18 , G01N33/68 , G01N33/543 , A61K38/17 , A61K39/395
CPC classification number: C07K16/18 , A61K38/1716 , A61K39/3955 , C07K16/005 , C07K2317/569 , C07K2317/622 , C07K2317/73 , C07K2317/76 , G01N33/5438 , G01N33/54386 , G01N33/6857 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognizes oligomeric Aβ that is resistant to denaturation by SDS but does not bind monomeric, fibrillar or other oligomeric forms of Aβ that are generated in vitro.
Abstract translation: 本发明涉及特异性识别通过SDS变性耐受但不结合在体外产生的Aβ的单体，纤维或其它寡聚形式的寡聚Aβ的抗体，抗体片段和结合剂。
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Patent Agency Ranking
6.发明申请ANTIBODY BASED REAGENTS THAT SPECIFICALLY RECOGNIZE TOXIC OLIGOMERIC FORMS OF TAU 有权特异性识别TAO毒性低分子形式的基于抗体的试剂公开(公告)号：US20150266947A1
公开(公告)日：2015-09-24
申请号：US14434742
申请日：2013-10-15
Applicant: Michael SIERKS , James G. MOE , Eliot DAVIDOWITZ , Huilai TIAN , ARIZONA BOARD OF AGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF
Inventor： Michael Sierks , Huilai Tian , James G. Moe , Eliot Davidowitz
CPC classification number: C07K16/18 , A61K2039/505 , C07K16/005 , C07K2317/21 , C07K2317/30 , C07K2317/62 , C07K2317/622 , C07K2317/76 , C12N15/1037 , G01N33/6896 , G01N2333/47 , G01N2333/4703 , G01N2800/28 , G01N2800/2814 , G01N2800/2821 , G01N2800/7047
Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomelic tau, fibrillar tau or non-disease associated forms of tau.
Abstract translation: 本发明涉及特异性识别寡聚tau但不结合单体tau，纤维状tau或非疾病相关形式的tau的抗体，抗体片段和结合剂。
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公开(公告)号：US5162210A
公开(公告)日：1992-11-10
申请号：US546511
申请日：1990-06-29
Applicant: Michael Sierks , Birte Svensson
Inventor： Michael Sierks , Birte Svensson
CPC classification number: C12N9/2428 , C12P19/20
Abstract: A process for converting starch or partially hydrolyzed starch into a syrup containing dextrose includes the steps of saccharifying starch hydrolyzate in the presence of a saccharifying starch hydrolyzate in the presence of a mutated glucoamylase or related enzyme and increasing the selectivity of the enzyme for .alpha.-(1.fwdarw.4)-glucosidic bonds by the glucoamylase or related enzyme by including at least one mutation, the mutation substituting an amino acid of the enzyme with at least one amino acid chosen by comparison with structurally related regions of other enzymes that selectively hydrolyze only .alpha.-(1.fwdarw.4) glucosidic bonds.Enzymes made in accordance with the present invention are also disclosed.
Abstract translation: 将淀粉或部分水解淀粉转化为含葡萄糖的糖浆的方法包括以下步骤：在糖化淀粉水解产物存在下，在突变葡糖淀粉酶或相关酶存在下糖化淀粉水解产物，并增加酶对α-（ 通过包括至少一个突变的葡糖淀粉酶或相关酶的1-> 4） - 葡糖苷键，将所述酶的氨基酸用至少一个氨基酸进行突变，所述氨基酸通过与仅选择性水解的其它酶的结构相关区域进行比较而选择 α-（1-> 4）糖苷键。 还公开了根据本发明制备的酶。
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公开(公告)号：US09340606B2
公开(公告)日：2016-05-17
申请号：US13821180
申请日：2011-10-26
Applicant: Michael Sierks , Srinath Kasturirangan
Inventor： Michael Sierks , Srinath Kasturirangan
IPC: C07K16/18 , G01N33/68 , G01N33/543 , A61K38/17 , A61K39/395
CPC classification number: C07K16/18 , A61K38/1716 , A61K39/3955 , C07K16/005 , C07K2317/569 , C07K2317/622 , C07K2317/73 , C07K2317/76 , G01N33/5438 , G01N33/54386 , G01N33/6857 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
Abstract: The present invention provides methods of immunization against Alzheimer's Disease and compositions for use in such methods.
Abstract translation: 本发明提供了免疫阿尔茨海默病的方法和用于这些方法的组合物。
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9.发明申请ANTIBODY BASED REAGENT THAT SPECIFICALLY RECOGNIZES TOXIC OLIGOMERIC FORM OF BETA-AMYLOID 有权抗体基于特异性识别β-淀粉样毒性低聚物形式的试剂公开(公告)号：US20140044733A1
公开(公告)日：2014-02-13
申请号：US13821172
申请日：2011-10-26
Applicant: Michael Sierks , Srinath Kasturirangan
Inventor： Michael Sierks , Srinath Kasturirangan
CPC classification number: C07K16/18 , A61K38/1716 , A61K39/3955 , C07K16/005 , C07K2317/569 , C07K2317/622 , C07K2317/73 , C07K2317/76 , G01N33/5438 , G01N33/54386 , G01N33/6857 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognizes oligomeric Aβ that is resistant to denaturation by SDS but does not bind monomeric, fibrillar or other oligomeric forms of Aβ that are generated in vitro.
Abstract translation: 本发明涉及抗体，抗体片段和特异性识别通过SDS变性抗性但不结合在体外产生的单体，纤维或其它寡聚形式的Abeta的寡聚Aβ的抗体片段和结合剂。
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公开(公告)号：US20130287800A1
公开(公告)日：2013-10-31
申请号：US13821180
申请日：2011-10-26
Applicant: Michael Sierks , Srinath Kasturirangan
Inventor： Michael Sierks , Srinath Kasturirangan
IPC: A61K38/17 , A61K39/395
CPC classification number: C07K16/18 , A61K38/1716 , A61K39/3955 , C07K16/005 , C07K2317/569 , C07K2317/622 , C07K2317/73 , C07K2317/76 , G01N33/5438 , G01N33/54386 , G01N33/6857 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
Abstract: The present invention provides methods of immunization against Alzheimer's Disease and compositions for use in such methods.
Abstract translation: 本发明提供了免疫阿尔茨海默病的方法和用于这些方法的组合物。
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