-
1.发明授权Synthesis of human secretory IgA and IgM and the formation of a medicament therefrom 有权人分泌型IgA和IgM的合成以及从其形成药物公开(公告)号：US08021645B2
公开(公告)日：2011-09-20
申请号：US12138758
申请日：2008-06-13
CPC分类号： C07K16/1282 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/76
摘要： A composition for treating a subject is provided. The composition includes antigen specific dimeric secretory IgA and pentameric IgM therapeutic. A process for manufacturing a medicament for the treatment of C. difficile associated disease in a human is also provided that the modification of antigen specific dimeric secretory IgA and pentameric IgM with secretory component to form a antigen specific dimeric secretory IgA and pentameric secretory IgM therapeutic. The antigen specific dimeric secretory IgA and the pentameric secretory IgM therapeutic is then mixed with formulating agents to create a capsule, tablet, liquid or suppository dosing form. The therapeutic is amenable to enrobement directly through microencapsulation or the dosing form is coated with an enteric coating. A method of C. difficile treatment with the therapeutic is also provided that is amenable to supplementation with concurrent or prior antibiotic administration.
摘要翻译： 提供了一种用于治疗受试者的组合物。 该组合物包括抗原特异性二聚体分泌型IgA和五聚体IgM治疗剂。 还提供了用于制备用于治疗人类艰难梭菌相关疾病的药物的方法，其中所述抗原特异性二聚体分泌型IgA和具有分泌成分的五聚体IgM的修饰形成抗原特异性二聚分泌型IgA和五聚体分泌型IgM治疗剂。 然后将抗原特异性二聚体分泌型IgA和五聚体分泌型IgM治疗剂与配制剂混合以产生胶囊，片剂，液体或栓剂给药形式。 该治疗剂适于直接通过微胶囊包被或剂量形式用肠溶衣包被。 还提供了用治疗剂进行艰难梭菌治疗的方法，其适于补充同时或之前的抗生素给药。
-
2.发明申请SYNTHESIS OF HUMAN SECRETORY IgA AND IgM AND THE FORMATION OF A MEDICAMENT THEREFROM 有权人类秘密IgA和IgM的合成及其药物的形成公开(公告)号：US20080260822A1
公开(公告)日：2008-10-23
申请号：US12138758
申请日：2008-06-13
CPC分类号： C07K16/1282 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/76
摘要： A composition for treating a subject is provided. The composition includes antigen specific dimeric secretory IgA and pentameric IgM therapeutic. A process for manufacturing a medicament for the treatment of C. difficile associated disease in a human is also provided that the modification of antigen specific dimeric secretory IgA and pentameric IgM with secretory component to form a antigen specific dimeric secretory IgA and pentameric secretory IgM therapeutic. The antigen specific dimeric secretory IgA and the pentameric secretory IgM therapeutic is then mixed with formulating agents to create a capsule, tablet, liquid or suppository dosing form. The therapeutic is amenable to enrobement directly through microencapsulation or the dosing form is coated with an enteric coating. A method of C. difficile treatment with the therapeutic is also provided that is amenable to supplementation with concurrent or prior antibiotic administration.
摘要翻译： 提供了一种用于治疗受试者的组合物。 该组合物包括抗原特异性二聚体分泌型IgA和五聚体IgM治疗剂。 还提供了用于制备用于治疗人类艰难梭菌相关疾病的药物的方法，其中所述抗原特异性二聚体分泌型IgA和具有分泌成分的五聚体IgM的修饰形成抗原特异性二聚分泌型IgA和五聚体分泌型IgM治疗剂。 然后将抗原特异性二聚体分泌型IgA和五聚体分泌型IgM治疗剂与配制剂混合以产生胶囊，片剂，液体或栓剂给药形式。 该治疗剂适于直接通过微胶囊包被或剂量形式用肠溶衣包被。 还提供了用治疗剂进行艰难梭菌治疗的方法，其适于补充同时或之前的抗生素给药。
-
公开(公告)号：US20190256577A1
公开(公告)日：2019-08-22
申请号：US16401322
申请日：2019-05-02
申请人： Stephen C. Brown , Michael R. Simon
发明人： Stephen C. Brown , Michael R. Simon
IPC分类号： C07K16/00 , C07K16/18 , C07K16/06 , C07K14/735
摘要： A process for synthesizing and separating secretory IgA from a mixture of IgA monmer and IgA dimer is provided. The process includes covalently binding affinity tagged or epitope tagged recombinant secretory component to the IgA dimer in the mixture and binding the affinity tagged or an epitope tagged secretory IgA to immobilized moieties on the solid phase support resin to which the affinity tag or epitope tag binds and then eluting the affinity tagged or an epitope tagged secretory IgA with release buffer. A process for synthesizing and separating secretory IgM from a mixture of IgM and other plasma proteins is also provided. The process includes covalently binding affinity tagged or an epitope tagged recombinant secretory component to the IgM in the mixture and binding the affinity tagged or an epitope tagged secretory IgM to immobilized moieties on the solid phase support resin and then eluting the peptide tagged secretory IgM with a release buffer.
-
公开(公告)号：US11623948B2
公开(公告)日：2023-04-11
申请号：US16401322
申请日：2019-05-02
申请人： Stephen C. Brown , Michael R. Simon
发明人： Stephen C. Brown , Michael R. Simon
摘要： A process for synthesizing and separating secretory IgA from a mixture of IgA monmer and IgA dimer is provided. The process includes covalently binding affinity tagged or epitope tagged recombinant secretory component to the IgA dimer in the mixture and binding the affinity tagged or an epitope tagged secretory IgA to immobilized moieties on the solid phase support resin to which the affinity tag or epitope tag binds and then eluting the affinity tagged or an epitope tagged secretory IgA with release buffer. A process for synthesizing and separating secretory IgM from a mixture of IgM and other plasma proteins is also provided. The process includes covalently binding affinity tagged or an epitope tagged recombinant secretory component to the IgM in the mixture and binding the affinity tagged or an epitope tagged secretory IgM to immobilized moieties on the solid phase support resin and then eluting the peptide tagged secretory IgM with a release buffer.
-
公开(公告)号：US10385117B2
公开(公告)日：2019-08-20
申请号：US14476559
申请日：2014-09-03
申请人： Stephen C. Brown , Michael R. Simon
发明人： Stephen C. Brown , Michael R. Simon
IPC分类号： A61K39/00 , C07K1/14 , C07K19/00 , B01D15/38 , C07K16/00 , C07K16/06 , C07K16/18 , C07K14/735
摘要： A process for synthesizing and separating secretory IgA from a mixture of IgA monomer and IgA dimer is provided. The process includes covalently binding affinity tagged or epitope tagged recombinant secretory component to the IgA dimer in the mixture and binding the affinity tagged or an epitope tagged secretory IgA to immobilized moieties on the solid phase support resin to which the affinity tag or epitope tag binds and then eluting the affinity tagged or an epitope tagged secretory IgA with release buffer. A process for synthesizing and separating secretory IgM from a mixture of IgM and other plasma proteins is also provided. The process includes covalently binding affinity tagged or an epitope tagged recombinant secretory component to the IgM in the mixture and binding the affinity tagged or an epitope tagged secretory IgM to immobilized moieties on the solid phase support resin and then eluting the peptide tagged secretory IgM with a release buffer.
-
公开(公告)号：US20170058018A2
公开(公告)日：2017-03-02
申请号：US14476559
申请日：2014-09-03
申请人： Stephen C. Brown , Michael R. Simon
发明人： Stephen C. Brown , Michael R. Simon
IPC分类号： C07K16/00
CPC分类号： C07K16/00 , A61K2039/505 , B01D15/3804 , C07K1/14 , C07K14/70535 , C07K16/065 , C07K16/18 , C07K2317/21 , C07K2319/036 , C07K2319/10 , C07K2319/32
摘要： A process for synthesizing and separating secretory IgA from a mixture of IgA monmer and IgA dimer is provided. The process includes covalently binding affinity tagged or epitope tagged recombinant secretory component to the IgA dimer in the mixture and binding the affinity tagged or an epitope tagged secretory IgA to immobilized moieties on the solid phase support resin to which the affinity tag or epitope tag binds and then eluting the affinity tagged or an epitope tagged secretory IgA with release buffer. A process for synthesizing and separating secretory IgM from a mixture of IgM and other plasma proteins is also provided. The process includes covalently binding affinity tagged or an epitope tagged recombinant secretory component to the IgM in the mixture and binding the affinity tagged or an epitope tagged secretory IgM to immobilized moieties on the solid phase support resin and then eluting the peptide tagged secretory IgM with a release buffer.
摘要翻译： 提供了从IgA单体和IgA二聚体的混合物合成和分离分泌型IgA的方法。 该方法包括将亲和标记或表位标记的重组分泌组分共价结合至混合物中的IgA二聚体，并将亲和标记的或表位标记的分泌型IgA与亲和标签或表位标签结合的固相支持树脂上的固定部分结合，以及 然后用释放缓冲液洗脱亲和标记或表位标记的分泌型IgA。 还提供了从IgM和其他血浆蛋白质的混合物中合成和分离分泌型IgM的方法。 该方法包括将亲和标记或表位标记的重组分泌组分共价结合到混合物中的IgM，并将亲和标记或表位标记的分泌型IgM结合到固相支持树脂上的固定化部分，然后用肽标记的分泌型IgM 释放缓冲液。
-
公开(公告)号：US20140371431A1
公开(公告)日：2014-12-18
申请号：US14476559
申请日：2014-09-03
IPC分类号： C07K16/00
CPC分类号： C07K16/00 , A61K2039/505 , B01D15/3804 , C07K1/14 , C07K14/70535 , C07K16/065 , C07K16/18 , C07K2317/21 , C07K2319/036 , C07K2319/10 , C07K2319/32
摘要： A process for synthesizing and separating secretory IgA from a mixture of IgA monomer and IgA dimer is provided. The process includes covalently binding affinity tagged or epitope tagged recombinant secretory component to the IgA dimer in the mixture and binding the affinity tagged or an epitope tagged secretory IgA to immobilized moieties on the solid phase support resin to which the affinity tag or epitope tag binds and then eluting the affinity tagged or an epitope tagged secretory IgA with release buffer. A process for synthesizing and separating secretory IgM from a mixture of IgM and other plasma proteins is also provided. The process includes covalently binding affinity tagged or an epitope tagged recombinant secretory component to the IgM in the mixture and binding the affinity tagged or an epitope tagged secretory IgM to immobilized moieties on the solid phase support resin and then eluting the peptide tagged secretory IgM with a release buffer.
摘要翻译： 提供了从IgA单体和IgA二聚体的混合物合成和分离分泌型IgA的方法。 该方法包括将亲和标记或表位标记的重组分泌组分共价结合至混合物中的IgA二聚体，并将亲和标记的或表位标记的分泌型IgA与亲和标签或表位标签结合的固相支持树脂上的固定部分结合，以及 然后用释放缓冲液洗脱亲和标记或表位标记的分泌型IgA。 还提供了从IgM和其他血浆蛋白质的混合物中合成和分离分泌型IgM的方法。 该方法包括将亲和标记或表位标记的重组分泌组分共价结合到混合物中的IgM，并将亲和标记或表位标记的分泌型IgM结合到固相支持树脂上的固定化部分，然后用肽标记的分泌型IgM 释放缓冲液。
-
公开(公告)号：US09227784B2
公开(公告)日：2016-01-05
申请号：US14302683
申请日：2014-06-12
申请人： James Laverdiere , Joshua Laverdiere , Stuart Olsen , Martin D. Flansbury , Michael R. Simon , Brian C. Bourque
发明人： James Laverdiere , Joshua Laverdiere , Stuart Olsen , Martin D. Flansbury , Michael R. Simon , Brian C. Bourque
摘要： A curved conveyor assembly includes a frame that defines a curved conveyance path. A conveyor belt is positioned on the frame system for travel along the curved conveyance path. At least one hold down guide is mounted to the frame and manually movable between an operating position and an access position. In the operating position a retaining lip of the hold down guide extends into the curved conveyance path proximate an edge of the conveyor belt for limiting upward movement of the edge of the conveyor belt. In the access position the retaining lip is moved away from the edge of the conveyor belt.
摘要翻译： 弯曲输送机组件包括限定弯曲输送路径的框架。 输送带位于框架系统上，以沿着弯曲的输送路径行进。 至少一个按压引导件被安装到框架并且可以在操作位置和访问位置之间手动地移动。 在操作位置，压紧引导件的保持唇缘延伸到靠近传送带边缘的弯曲输送路径中，以限制输送带边缘向上运动。 在进入位置，保持唇缘移动远离传送带的边缘。
-
9.发明授权公开(公告)号：US07794721B2
公开(公告)日：2010-09-14
申请号：US11851606
申请日：2007-09-07
申请人： Michael R. Simon
发明人： Michael R. Simon
IPC分类号： A61K39/00 , A61K39/395 , A61K39/02
CPC分类号： A61K31/415 , A61K38/14 , C07K16/1282 , C07K2317/21 , C07K2317/52
摘要： A composition for treating a subject is provided. The composition includes a pentameric secretory IgM therapeutic. Formulating agents are mixed with the pentameric secretory IgM to yield a dosing form of a capsule, tablet, and a suppository. A process for manufacturing a medicament for the treatment of C. difficile associated disease in a human is also provided that the modification of pentameric IgM with secretory component to form a pentameric secretory IgM therapeutic. The pentameric secretory IgM therapeutic is then mixed with formulating agents to create a capsule, tablet, or suppository dosing form. The therapeutic is amenable to enrobement directly through microencapsulation or the dosing form is coated with an enteric coating. A method of C. difficile treatment with the therapeutic is also provided that is amenable to supplementation with concurrent or prior antibiotic administration.
摘要翻译： 提供了一种用于治疗受试者的组合物。 该组合物包括五聚体分泌型IgM治疗剂。 将制剂与五聚体分泌型IgM混合以产生胶囊，片剂和栓剂的给药形式。 制备用于治疗人类艰难梭菌相关疾病的药物的方法还提供了用分泌组分修饰五聚体IgM以形成五聚体分泌型IgM治疗剂。 然后将五聚体分泌型IgM治疗剂与配制剂混合以产生胶囊，片剂或栓剂给药形式。 该治疗剂适于直接通过微胶囊包被或剂量形式用肠溶衣包被。 还提供了用治疗剂进行艰难梭菌治疗的方法，其适于补充同时或之前的抗生素给药。
-
10.发明申请HUMAN SECRETORY IgA FOR THE TREATMENT OF CLOSTRIDIUM DIFFICILE ASSOCIATED DISEASES 审中-公开人类秘密IgA治疗闭锁性相关疾病公开(公告)号：US20080145420A1
公开(公告)日：2008-06-19
申请号：US11610154
申请日：2006-12-13
申请人： Michael R. Simon
发明人： Michael R. Simon
CPC分类号： C07K16/1282 , A61K38/14 , A61K47/6811 , A61K47/6835 , C07K2317/21 , A61K2300/00
摘要： A composition for treating a subject is provided. The composition includes dimeric or polymeric IgA therapeutic. Formulating agents are mixed with the dimeric or polymeric IgA to yield a dosing form of a capsule, tablet, and a suppository. A process for manufacturing a medicament for the treatment of C. difficile associated disease in a human is also provided that the sequential modification of monomeric IgA with J chain and secretory component to form a dimeric or polymeric IgA therapeutic. The dimeric or polymeric IgA therapeutic is then mixed with formulating agents to create a capsule, tablet, or suppository dosing form. The therapeutic is amenable to enrobement directly through microeneapsulation or the dosing form is coated with an enteric coating. A method of C. difficile treatment with the therapeutic is also provided that is amenable to supplementation with concurrent or prior antibiotic administration.
摘要翻译： 提供了一种用于治疗受试者的组合物。 该组合物包括二聚体或聚合物IgA治疗剂。 将制剂与二聚体或聚合物IgA混合以产生胶囊，片剂和栓剂的给药形式。 还提供了用于制备用于治疗人类艰难梭菌相关疾病的药物的方法，所述方法是用J链和分泌组分连续修饰单体IgA以形成二聚体或聚合物IgA治疗剂。 然后将二聚体或聚合物IgA治疗剂与配制剂混合以产生胶囊，片剂或栓剂给药形式。 治疗剂适于直接通过微胶囊包被，或者给药形式用肠溶衣包被。 还提供了用治疗剂进行艰难梭菌治疗的方法，其适于补充同时或之前的抗生素给药。
-
-
-
-
-
-
-
-
-
搜索结果
32 条记录 (耗时 0.027 秒)
