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公开(公告)号：US08475487B2
公开(公告)日：2013-07-02
申请号：US11101224
申请日：2005-04-07
Applicant: Michael J. Bonnette , Eric J. Thor , Daniel T. Janse
Inventor： Michael J. Bonnette , Eric J. Thor , Daniel T. Janse
CPC classification number: A61B17/320758 , A61B17/00234 , A61B17/320725 , A61B2017/22079 , A61B2017/22082 , A61B2017/320004 , A61B2217/005 , A61B2217/007
Abstract: A cross stream thrombectomy catheter with a flexible and expandable cage preferably formed of nitinol for removal of hardened and aged thrombotic material stubbornly attached to the interior of a blood vessel. The cage, which can be mesh or of straight or spiral filament design, is located close to inflow and outflow orifices at the distal portion of a catheter tube and is deployed and extended at a thrombus site for intimate contact therewith and for action of a positionable assembly and subsequent rotation and lineal actuation to abrade, grate, scrape, or otherwise loosen and dislodge difficult to remove thrombus which can interact with cross stream flows to exhaust free and loosened thrombotic particulate through the catheter tube. An alternative embodiment discloses a mechanism involving a threaded tube in rotatable engagement with an internally threaded sleeve to incrementally control the deployment and expansion of the flexible and expandable cages.
Abstract translation: 一种交叉流血栓切除术导管，其具有优选由镍钛诺形成的柔性和可膨胀的保持架，用于去除顽固地附着在血管内部的硬化和老化的血栓形成材料。 可以是网状或直线或螺旋丝设计的笼子位于靠近导管管的远端部分处的流入和流出孔口，并且在血栓位置部署和延伸以与其紧密接触并且用于可定位的动作 组装和随后的旋转和线性致动以磨擦，磨碎，刮擦或以其它方式松动和移除难以去除血栓，其可以与交叉流相互作用以通过导管管排出无松动和松动的血栓形成颗粒。 替代实施例公开了一种机构，其涉及可旋转地与内螺纹套筒接合的螺纹管，以递增地控制柔性和可扩展笼的展开和膨胀。
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公开(公告)号：US20080234722A1
公开(公告)日：2008-09-25
申请号：US11811974
申请日：2007-06-13
Applicant: Michael J. Bonnette , Eric J. Thor , Daniel T. Janse , Ernest R. Scherger
Inventor： Michael J. Bonnette , Eric J. Thor , Daniel T. Janse , Ernest R. Scherger
IPC: A61F2/01
CPC classification number: A61F2/013 , A61F2002/016 , A61F2230/0071 , A61F2230/0076 , A61F2230/0093
Abstract: A temporary inferior vena cava filter including a guidewire and a doublet cage filter distally located on the guidewire. The doublet cage filter has a proximal cage filter and a distal cage filter, both of resilient and biased toward their expanded or deployed state. The proximal and distal cage filters may be collapsed by actuation, preferably with a sheath. A method of protecting from pulmonary embolism during treatment of a deep vein thrombosis is disclosed. The doublet cage provides stability when deployed in the inferior vena cava, is readily retrieved and readily manufactured. A method of manufacturing the doublet cage filter assembly is also disclosed and involves a nitinol tube with plural cuts to form struts which are heat treated in an expanded state.
Abstract translation: 一种临时下腔静脉滤器，包括导丝和导向线上远端的双网笼过滤器。 双层笼式过滤器具有近端笼式过滤器和远端笼式过滤器，其具有弹性并偏向其膨胀或展开状态。 近端和远端笼式过滤器可以通过致动而折叠，优选地具有护套。 公开了在治疗深静脉血栓形成期间防止肺栓塞的方法。 双层保持架在部署在下腔静脉时提供稳定性，容易回收并容易制造。 还公开了制造双层笼式过滤器组件的方法，并且涉及具有多个切口的镍钛诺管以形成在膨胀状态下进行热处理的支柱。
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公开(公告)号：US08647294B2
公开(公告)日：2014-02-11
申请号：US12933520
申请日：2009-03-20
Applicant: Michael J. Bonnette , Eric J. Thor , Debra M. Kozak , Douglas J. Ball , Stephen E. Weisel , David B. Morris
Inventor： Michael J. Bonnette , Eric J. Thor , Debra M. Kozak , Douglas J. Ball , Stephen E. Weisel , David B. Morris
CPC classification number: A61M25/0068 , A61B17/32037 , A61M25/10
Abstract: A direct stream hydrodynamic catheter system is provided for the removal of thrombus, lesions and the like including provisions for the infusion of drugs, lysing fluids and the like into a blood vessel. Physician controlled high powered direct fluid jet streams emanate from a fluid jet emanator in the form of robust radially directed fluid jet streams to impinge upon and ablate difficult and strong thrombus or lesions within a blood vessel. Effluent aspiration is controlled by an exhaust regulator in the form of a roller pump, but effluent removal can be assistingly influenced by the fluid pressure associated with the radially directed fluid jet streams.
Abstract translation: 提供了一种用于去除血栓，病变等的直流流体动力导管系统，包括用于将药物输注，将流体等裂解成血管的规定。 医师控制的高功率直接流体射流从流体喷射发射器发出，形式为坚固的径向指向的流体射流，以冲击和消融血管内的困难和强烈的血栓或病变。 流出物抽吸由辊式泵的排气调节器控制，但流出物的去除可能受到与径向定向的流体喷流相关联的流体压力的帮助。
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公开(公告)号：US20130138086A1
公开(公告)日：2013-05-30
申请号：US13814804
申请日：2011-08-11
Applicant: Eric J. Thor , Douglas J. Ball , Lief E. Leirfallom , Michael J. Bonnette , Jason M. Bronstad , Jason Anderson
Inventor： Eric J. Thor , Douglas J. Ball , Lief E. Leirfallom , Michael J. Bonnette , Jason M. Bronstad , Jason Anderson
IPC: A61M25/00
CPC classification number: A61M25/0014 , A61M39/10 , A61M39/1011 , A61M39/12 , A61M2025/0098 , A61M2039/1038 , A61M2039/1066
Abstract: Fluid infusion systems and fluid couplings are described herein. The infusion systems may include one or more fluid couplings used to make fluidic connection between a supply line and delivery tubing. The fluid couplings separate the functions of providing a seal around a delivery tube and retaining the delivery tube within the fluid coupling. The seal provided around the delivery tube prevents leakage around an exterior surface of a delivery tube such that fluid passing through the coupling must pass through the delivery tube rather than leak around the delivery tube. The structure used to retain the delivery tube in the fluid coupling prevents ejection of the delivery tube from the coupling due to the fluid pressures present in the coupling. The separate functions are performed by different structures within the fluid couplings.
Abstract translation: 本文描述了流体输注系统和流体联接器。 输注系统可以包括用于在供应管线和输送管道之间进行流体连接的一个或多个流体联接器。 流体联轴器分离了在输送管周围提供密封并将输送管保持在流体联接器内的功能。 提供在输送管周围的密封件防止在输送管的外表面周围的泄漏，使得通过联接器的流体必须通过输送管，而不是泄漏在输送管周围。 用于将输送管保持在流体联接器中的结构防止由于联接器中存在的流体压力而将输送管从联接件中排出。 单独的功能由流体联轴器内的不同结构执行。
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公开(公告)号：US20130131594A1
公开(公告)日：2013-05-23
申请号：US13813221
申请日：2011-08-03
Applicant: Michael J. Bonnette , Debra M. Kozak , Eric J. Thor , Richard R. Prather
Inventor： Michael J. Bonnette , Debra M. Kozak , Eric J. Thor , Richard R. Prather
CPC classification number: A61M25/10 , A61F2/958 , A61M25/0032 , A61M25/0097 , A61M25/1002 , A61M25/1034 , A61M25/1036 , A61M25/104 , A61M2025/105 , A61M2025/1086
Abstract: A balloon catheter (10) having a shaft (16), a balloon (14), and an external delivery tube (12) is disclosed. Methods of using the balloon catheter having an external delivery tube are also disclosed. In one example, the balloon catheter is an agent delivery catheter including a catheter body extending between catheter proximal and distal portions. An inflatable balloon assembly (100) is coupled with the catheter body. An agent delivery assembly (102) is coupled with the catheter body and the inflatable balloon assembly. The agent delivery assembly includes a delivery lumen (32) extending through the catheter body, and an agent delivery tube extending along an exterior balloon surface (64). The agent delivery tube includes at least one delivery orifice (70) directed outside of the exterior balloon surface. The agent delivery assembly is isolated from fluid communication with the inflatable balloon assembly.
Abstract translation: 公开了一种具有轴（16），气球（14）和外部输送管（12）的球囊导管（10）。 还公开了使用具有外部输送管的气囊导管的方法。 在一个示例中，气囊导管是包括在导管近端部分和远端部分之间延伸的导管主体的药剂输送导管。 可充气球囊组件（100）与导管主体联接。 药剂输送组件（102）与导管主体和可充气球囊组件联接。 药剂输送组件包括延伸穿过导管主体的递送腔（32）和沿外部气囊表面（64）延伸的药剂输送管。 药剂输送管包括指向外气囊表面外部的至少一个输送孔（70）。 药剂输送组件与可充气球囊组件的流体连通隔离。
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Patent Agency Ranking
6.发明授权Rheolytic thrombectomy catheter with self-inflating proximal balloon with drug infusion capabilities 有权溶血性血栓切除术导管带有自充气近端球囊药物输注能力公开(公告)号：US08439878B2
公开(公告)日：2013-05-14
申请号：US12338376
申请日：2008-12-18
Applicant: Michael J. Bonnette , Eric J. Thor , Debra M. Kozak
Inventor： Michael J. Bonnette , Eric J. Thor , Debra M. Kozak
IPC: A61M5/178
CPC classification number: A61B17/32037 , A61B2017/22062 , A61B2017/22065
Abstract: A thrombectomy catheter with a self-inflating proximal balloon having drug infusion capabilities is described. A self-inflating balloon is formed from an inflatable thin walled section of a flexible catheter tube. The self-inflating balloon includes a plurality of outflow orifices located about the peripheral circumference thereof and located proximal to an inflow gap interposed between a fluid jet emanator and the self-inflating balloon. The self-inflating balloon is inflated and expanded by internal operating pressures by proximal composite flow of fluid from the fluid jet emanator and entrained fluid from the inflow gap to uniformly space and position the outflow orifices of the self-inflating balloon in close proximity to the thrombus or vessel walls of a blood vessel. The thrombectomy catheter may be used for, among other things, thrombectomies, embolectomies, thrombus or vessel dilation, and for the delivery of drugs to a thrombus or vessel site.
Abstract translation: 描述了具有药物输注能力的具有自充气近端球囊的血栓切除术导管。 自充气气囊由柔性导管的可膨胀薄壁部分形成。 自膨胀气囊包括多个位于其周边周围的流出孔，位于流体喷射发生器和自膨胀气囊之间的入口间隙附近。 自充气气球通过内部操作压力通过来自流体喷射发生器的流体的近似复合流动和来自流入间隙的夹带的流体膨胀和膨胀，以将自膨胀气囊的流出孔均匀地间隔并定位在紧邻 血栓或血管壁。 血栓切除术导管可以用于血栓切除术，静脉血栓栓塞，血栓或血管扩张，以及用于将药物递送至血栓或血管部位。
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公开(公告)号：US20080312681A1
公开(公告)日：2008-12-18
申请号：US12152367
申请日：2008-05-14
Applicant: Gary M. Ansel , Michael J. Bonnette , Eric J. Thor , David B. Morris , Stephen D. Weisel
Inventor： Gary M. Ansel , Michael J. Bonnette , Eric J. Thor , David B. Morris , Stephen D. Weisel
IPC: A61M29/00
CPC classification number: A61M25/0662 , A61B17/22031 , A61B17/221 , A61B2017/00867 , A61B2017/22044 , A61B2017/22067 , A61B2017/22094 , A61F2002/011 , A61M25/005 , A61M2025/0175 , A61M2025/1052
Abstract: The general purpose of the present invention is to provide a catheter for removal of an organized embolic thrombus, preferably in conjunction with a distal occlusion balloon guidewire. The present invention consists of three main components including a capture/delivery sheath, a capture sleeve of mesh attached to a tube and a grasping mechanism attached to another tube which is central to the other components. Operative structures in the form of manifolds are connected to such components in order to manipulate and control the relative positions of the capture/delivery sheath, the capture sleeve and the grasping mechanism. An embolic thrombus is engaged by the deployable automatically expanding serrated fingers of a grasping mechanism in combination with a deployable automatically expanding mesh capture sleeve. The capture/delivery sheath is maneuvered to cause compression of the serrated fingers and of the mesh capture sleeve for subsequent removal of the embolic thrombus.
Abstract translation: 本发明的总体目的是提供一种用于去除有组织的栓塞性血栓的导管，优选与远端阻塞气囊导丝结合。 本发明包括三个主要部件，包括捕获/传送鞘，连接到管的网的捕获套管和附接到另一个组件中心的另一管的抓握机构。 歧管形式的操作结构连接到这些部件上，以便操纵和控制捕获/传送鞘，捕获套管和把持机构的相对位置。 栓塞血栓由可部署的自动扩张的抓握机构的锯齿状手指与可展开的自动扩张的网状捕获套管结合。 捕获/传送鞘被操纵以引起锯齿状手指和网状物捕获套筒的压缩，以便随后去除栓塞血栓。
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公开(公告)号：US20080287986A1
公开(公告)日：2008-11-20
申请号：US12152368
申请日：2008-05-14
Applicant: Eric J. Thor , Michael J. Bonnette , Richard R. Prather , Jason T. Anderson
Inventor： Eric J. Thor , Michael J. Bonnette , Richard R. Prather , Jason T. Anderson
IPC: A61B17/08
CPC classification number: A61B17/0057 , A61B2017/00004 , A61B2017/0065 , A61B2017/00654
Abstract: The present invention is for an arterial closure device which can be used to implement and augment the closure of a femoral artery or other related, adjacent or similar members of the vasculature and to reduce compression times associated therewith. A resorbable tubular plug is introduced through a delivery sheath subsequent to a procedure in which the delivery sheath is first utilized. The resorbable tubular plug is inserted through the delivery sheath and the distal tip of the resorbable tubular plug is positioned a short distance into the artery, whereby a suitable entry can be indicated by blood flow through and from the resorbable tubular plug. The delivery sheath is withdrawn to expose the resorbable tubular plug to the tissue track and to the arteriotomy and manual compression is applied to the wound site to foster and promote hemostasis.
Abstract translation: 本发明涉及一种动脉闭合装置，其可以用于实现和增加脉管系统的股动脉或其它相关的，相邻的或相似的构件的闭合并且减少与其相关联的压缩时间。 在首先使用输送护套的过程之后，可再吸收的管状塞子通过输送护套引入。 可再吸收的管状插头插入穿过输送护套，并且可再吸收的管状塞子的远端位于动脉的短距离处，由此通过可再吸收的管状塞子的血液流动可以指示合适的入口。 将输送护套取出以将可再吸收的管状塞子暴露于组织轨迹和动脉切开术，并且将手动压缩施加到伤口部位以促进和促进止血。
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公开(公告)号：US08974418B2
公开(公告)日：2015-03-10
申请号：US12009807
申请日：2008-01-22
Applicant: Michael J. Bonnette , David B. Morris , Eric J. Thor
Inventor： Michael J. Bonnette , David B. Morris , Eric J. Thor
IPC: A61M5/178 , A61B17/3203
CPC classification number: A61B17/32037 , A61B2017/32032
Abstract: A forwardly directed fluid jet crossing catheter having a distally directed cylindrical flow fluid jet stream to cross a chronic total occlusion is set forth. The distal end of the device includes a formable catheter tip region having flexible internal components. Low and high pressure cavities are formed substantially by joined proximal and distal catheter tubes having an adhesive plug seal in common therebetween which partially defines one end of each of the low pressure and high pressure cavities. A guidewire tube and a high pressure tube are aligned along and within the low pressure and high pressure cavities and through the adhesive plug seal. The high pressure tube openly terminates in the high pressure cavity, whereby pressurized fluid transfers from the high pressure cavity in the guidewire tube entry hole to subsequently pass along the guidewire lumen and co-located guidewire to exit as a cylindrical fluid jet stream.
Abstract translation: 阐述了具有远端定向的圆柱形流动流体射流以横穿慢性完全闭塞的向前导向的流体射流交叉导管。 该装置的远端包括具有柔性内部部件的可成形的导管尖端区域。 基本上通过连接的近端和远端导管管形成低压腔和高压腔，所述导管具有共同的粘合剂塞密封件，其部分地限定每个低压腔和高压腔的一端。 导丝管和高压管在低压和高压腔内并通过粘合剂塞密封件对准。 高压管在高压腔体中公开地终止，由此加压流体从导丝管入口孔中的高压腔转移，随后沿着导丝管腔和共同定位的导丝线流过圆柱形流体喷射流。
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公开(公告)号：US08951229B2
公开(公告)日：2015-02-10
申请号：US13032185
申请日：2011-02-22
Applicant: Michael J. Bonnette , Eric J. Thor , Stephen E. Weisel , Arthur E. Uber, III , Leif E. Leirfallom , Laszlo T. Farago
Inventor： Michael J. Bonnette , Eric J. Thor , Stephen E. Weisel , Arthur E. Uber, III , Leif E. Leirfallom , Laszlo T. Farago
CPC classification number: A61M39/0613 , A61M2039/062
Abstract: A catheter includes a pressure actuated seal within a manifold. A catheter body is coupled with the manifold, and a manifold lumen and a catheter lumen are configured to receive pressurized fluids. The pressure actuated seal includes a pressure actuated seal element having a seal element lumen. The seal element lumen is in communication with the manifold and catheter lumens. The pressure actuated seal element is deformable between an open configuration and a sealed configuration. In the sealed configuration, the pressurized fluids in the manifold press on the pressure actuated seal element along a first seal face. The pressure actuated seal element compresses inwardly around the seal element lumen according to a pressure of the pressurized fluids. In the open configuration, the pressure actuated seal element relaxes in an absence of the pressurized fluids, and the seal element lumen is open and configured to allow passage of an instrument.
Abstract translation: 导管包括歧管内的压力致动密封件。 导管主体与歧管联接，并且歧管内腔和导管内腔构造成接收加压流体。 压力致动密封件包括具有密封元件内腔的压力致动的密封元件。 密封元件腔与歧管和导管腔连通。 压力致动的密封元件可在打开构型和密封构型之间变形。 在密封构造中，歧管中的加压流体沿着第一密封面压在压力致动的密封元件上。 压力致动的密封元件根据加压流体的压力向内压缩密封元件内腔。 在打开构造中，压力驱动的密封元件在没有加压流体的情况下松弛，并且密封元件内腔是打开的并且被构造成允许器械通过。
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