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12 条记录 (耗时 0.017 秒)

    Use of a compound for enhancing the expression of membrane proteins on the cell surface
    4.
    发明申请
    Use of a compound for enhancing the expression of membrane proteins on the cell surface 审中-公开
    使用化合物来增强膜蛋白在细胞表面的表达

    公开(公告)号：US20060008454A1

    公开(公告)日：2006-01-12

    申请号：US10886202

    申请日：2004-07-07

    申请人： Michael Freissmuth ,  Tetyana Kirpenko ,  Christian Nanoff

    发明人： Michael Freissmuth ,  Tetyana Kirpenko ,  Christian Nanoff

    IPC分类号： A61K38/46

    CPC分类号： A61K38/06 ,  A61K38/465 ,  A61K38/4813 ,  A61K2300/00

    摘要： The present invention is directed to the use of a compound stimulating deubiquitinating activity in a cell for the manufacture of a medicament for enhancing the expression of integral membrane proteins on the cell surface. Especially, the invention is directed to the use of such compound for the manufacture of a medicament for the treatment of a disease of condition selected from the group consisting of cystic fibrosis, diabetes insipidus, hypercholesterinaemia and long QT-syndrome-2.

    摘要翻译： 本发明涉及在细胞中刺激去泛素化活性的化合物在制备用于增强细胞表面上的整合膜蛋白表达的药物中的用途。 特别地，本发明涉及这种化合物在制备用于治疗选自囊性纤维化，尿崩症，高胆固醇血症和长QT综合征-2的疾病疾病的药物中的用途。

    USE OF A PREPARATION BASED ON AN ANTIBODY DIRECTED AGAINST A TUMOR-ASSOCIATED GLYCOSYLATION
    5.
    发明申请
    USE OF A PREPARATION BASED ON AN ANTIBODY DIRECTED AGAINST A TUMOR-ASSOCIATED GLYCOSYLATION 审中-公开
    基于针对肿瘤相关糖蛋白的抗体的制备的使用

    公开(公告)号：US20090181030A1

    公开(公告)日：2009-07-16

    申请号：US12391226

    申请日：2009-02-23

    申请人： Hans LOIBNER ,  Gottfried Himmler ,  Thomas Putz ,  Michael Freissmuth ,  Markus Klinger ,  Hesso Farhan

    发明人： Hans LOIBNER ,  Gottfried Himmler ,  Thomas Putz ,  Michael Freissmuth ,  Markus Klinger ,  Hesso Farhan

    IPC分类号： A61K39/395 ,  A61P35/00

    CPC分类号： C07K16/30 ,  A61K39/395 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/77 ,  A61K2300/00

    摘要： The invention relates to the use of a preparation based on an antibody directed against a tumor-associated glycosylation for preparing a medicament for the prophylactic and/or therapeutic treatment for the reduction or inhibition, respectively, of the growth of tumor cells in a cancer patient, as well as to a pharmaceutical preparation containing an antibody directed against a tumor-associated glycosylation. Moreover, the invention relates to a preparation for pharmaceutical and/or diagnostic use, a diagnostic method and an agent for determining the risk of metastasis formation in a cancer patient, as well as a method of producing a preparation based on a body fluid or tissue, in each case using the antibody directed against a tumor-associated glycosylation.

    摘要翻译： 本发明涉及基于针对肿瘤相关糖基化的抗体的制剂的制备用于制备用于预防和/或治疗治疗癌症患者中肿瘤细胞生长的减少或抑制的药物的用途 ，以及含有针对肿瘤相关糖基化的抗体的药物制剂。 此外，本发明涉及用于药物和/或诊断用途的制剂，用于确定癌症患者转移形成风险的诊断方法和试剂，以及基于体液或组织制备制剂的方法 在每种情况下使用针对肿瘤相关糖基化的抗体。

    METHOD FOR ENHANCING ENGRAFTMENT OF HAEMATOPOETIC STEM CELLS
    6.
    发明申请
    METHOD FOR ENHANCING ENGRAFTMENT OF HAEMATOPOETIC STEM CELLS 审中-公开
    增强肝细胞癌细胞增殖的方法

    公开(公告)号：US20130344038A1

    公开(公告)日：2013-12-26

    申请号：US13979332

    申请日：2012-01-13

    申请人： Michael Freissmuth ,  Eva-Maria Zebedin-Brandl ,  Christian Bergmayr ,  Filza Hussain

    发明人： Michael Freissmuth ,  Eva-Maria Zebedin-Brandl ,  Christian Bergmayr ,  Filza Hussain

    IPC分类号： A61K35/28

    CPC分类号： A61K35/28 ,  A61K31/5585 ,  C12N5/0647 ,  C12N2501/01 ,  Y02A50/471 ,  A61K2300/00

    摘要： The present invention provides a novel method for enhancing engraftment of haematopoetic stem cells by an ex-vivo pretreatment comprising the steps of obtaining a sample containing haematopoetic stem cells and admixing a prostacyclin analogue to obtain a mixture, incubating said mixture for a period of time sufficient to stimulate G alphas-signalling in said cells and optionally and isolating said stimulated cells. Further, a composition comprising a prostacyclin analogue for use in the treatment of individuals undergoing haematopoetic stem cell transplantation is provided.

    摘要翻译： 本发明提供了一种通过离体预处理增强造血干细胞植入的新方法，其包括以下步骤：获得含有造血干细胞的样品并混合前列环素类似物以获得混合物，将所述混合物温育足够的时间 以刺激所述细胞中的Gαα信号，并任选地分离所述受激细胞。 此外，提供了包含用于治疗经历造血干细胞移植的个体的前列环素类似物的组合物。

    Use of a preparation based on an antibody directed against a tumor-associated glycosylation
    7.
    发明申请
    Use of a preparation based on an antibody directed against a tumor-associated glycosylation 有权
    使用基于针对肿瘤相关糖基化的抗体的制剂

    公开(公告)号：US20050226880A1

    公开(公告)日：2005-10-13

    申请号：US10519323

    申请日：2003-06-30

    申请人： Hans Loibner ,  Gottried Himmler ,  Thomas Putz ,  Michael Freissmuth ,  Markus Klinger ,  Hesso Farhan

    发明人： Hans Loibner ,  Gottried Himmler ,  Thomas Putz ,  Michael Freissmuth ,  Markus Klinger ,  Hesso Farhan

    IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K16/28 ,  C07K16/30

    CPC分类号： C07K16/30 ,  A61K39/395 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/77 ,  A61K2300/00

    摘要： The invention relates to the use of a preparation based on -an antibody directed against a tumor-associated glycosylation for preparing a medicament for the prophylactic and/or therapeutic treatment for the reduction or inhibition, respectively, of the growth of tumor cells in a cancer patient, as well as to a pharmaceutical preparation containing an antibody directed against a tumor-associated glycosylation. Moreover, the invention relates to a preparation for pharmaceutical and/or diagnostic use, a diagnostic method and an agent for determining the risk of metastasis formation in a cancer patient, as well as a method of producing a preparation based on a body fluid or tissue, in each case using the antibody directed against a tumor-associated glycosylation.

    摘要翻译： 本发明涉及基于针对肿瘤相关糖基化的抗体的制备物的制备用于制备分别用于预防和/或治疗治疗癌症细胞在癌症中的生长的预防和/或治疗性治疗的药物 患者以及含有针对肿瘤相关糖基化的抗体的药物制剂。 此外，本发明涉及用于药物和/或诊断用途的制剂，用于确定癌症患者转移形成风险的诊断方法和试剂，以及基于体液或组织制备制剂的方法 在每种情况下使用针对肿瘤相关糖基化的抗体。